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[A study of the properties of compacts from a mixed dry binder on the base of alpha-lactose monohydrate and microcrystalline cellulose].
Ceska Slov Farm. 2005 May; 54(3):118-22.CS

Abstract

The paper studies the tensile strength and disintegration time of compacts from the mixed dry binder MicroceLac 100. Tensile strength and disintegration time of tablets were tested in connection with the following factors: compression force, compression rate, addition of magnesium stearate, addition of ascorbic acid, the model active principle. The compression forces employed were 5, 6, and 7 kN, compression rates, 20 and 40 mm/min, stearate concentration 0, 0.4, and 0.8%, ascorbic acid concentration, 25 and 50%. With increasing addition of the stearate, the strength of compacts from MicroceLacu 100 was decreased for both compression rates, but with a higher rate, in a concentration of 0.4%, the decrease in strength was more marked. Disintegration time was increased with compression force and the addition of the stearate, but in all cases it was very short. Increased addition of ascorbic acid further intensified the decrease in the strength of compacts and decreased the disintegration time and the effect of the stearate on it. Disintegration time of compacts with ascorbic acid in a concentration of 50% did not increase with compression force.

Authors+Show Affiliations

Muzíková J
Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologie. muzikova@faf.cuni.cz
Páleník L
No affiliation info available

MeSH

CelluloseCompressive StrengthLactosePharmaceutic AidsStearic AcidsTabletsTensile Strength

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

cze

PubMed ID

15945458

Citation

Muzíková, J, and L Páleník. "[A Study of the Properties of Compacts From a Mixed Dry Binder On the Base of Alpha-lactose Monohydrate and Microcrystalline Cellulose]." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 54, no. 3, 2005, pp. 118-22.
Muzíková J, Páleník L. [A study of the properties of compacts from a mixed dry binder on the base of alpha-lactose monohydrate and microcrystalline cellulose]. Ceska Slov Farm. 2005;54(3):118-22.
Muzíková, J., & Páleník, L. (2005). [A study of the properties of compacts from a mixed dry binder on the base of alpha-lactose monohydrate and microcrystalline cellulose]. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 54(3), 118-22.
Muzíková J, Páleník L. [A Study of the Properties of Compacts From a Mixed Dry Binder On the Base of Alpha-lactose Monohydrate and Microcrystalline Cellulose]. Ceska Slov Farm. 2005;54(3):118-22. PubMed PMID: 15945458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A study of the properties of compacts from a mixed dry binder on the base of alpha-lactose monohydrate and microcrystalline cellulose]. AU - Muzíková,J, AU - Páleník,L, PY - 2005/6/11/pubmed PY - 2005/10/28/medline PY - 2005/6/11/entrez SP - 118 EP - 22 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 54 IS - 3 N2 - The paper studies the tensile strength and disintegration time of compacts from the mixed dry binder MicroceLac 100. Tensile strength and disintegration time of tablets were tested in connection with the following factors: compression force, compression rate, addition of magnesium stearate, addition of ascorbic acid, the model active principle. The compression forces employed were 5, 6, and 7 kN, compression rates, 20 and 40 mm/min, stearate concentration 0, 0.4, and 0.8%, ascorbic acid concentration, 25 and 50%. With increasing addition of the stearate, the strength of compacts from MicroceLacu 100 was decreased for both compression rates, but with a higher rate, in a concentration of 0.4%, the decrease in strength was more marked. Disintegration time was increased with compression force and the addition of the stearate, but in all cases it was very short. Increased addition of ascorbic acid further intensified the decrease in the strength of compacts and decreased the disintegration time and the effect of the stearate on it. Disintegration time of compacts with ascorbic acid in a concentration of 50% did not increase with compression force. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/15945458/[A_study_of_the_properties_of_compacts_from_a_mixed_dry_binder_on_the_base_of_alpha_lactose_monohydrate_and_microcrystalline_cellulose]_ DB - PRIME DP - Unbound Medicine ER -