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Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma.
J Gastroenterol Hepatol 2005; 20(6):850-6JG

Abstract

BACKGROUND

The prevalence of prior hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients and its role in hepatocarcinogenesis are not clear. The aim of the present study is to clarify the importance of prior HBV infection in development of HCC.

METHODS

Of 1288 consecutive HCC patients between January 1999 and October 2002, 1008 patients were enrolled. To determine the influence of prior HBV infection in hepatitis B surface antigen (HBsAg)-negative HCC, the prevalence of antibody to hepatitis B core antigen (anti-HBc) was examined according to age, and the clinical features were compared between the anti-HBc positive and the negative groups.

RESULTS

The proportion of HBsAg-negative HCC patients, HCC patients with antibody to hepatitis C virus (anti-HCV; C-HCC) and HCC patients negative for both HBsAg and anti-HCV (nBnC-HCC), increased with age. The anti-HBc-positive rates in C-HCC patients also increased with age. Those rates in nBnC-HCC patients were >50% in all age groups. Furthermore, it was found that the anti-HBc-positive rates of these patients were higher than those of corresponding control patients. Tumor size and a positive rate for vessel involvement both in C-HCC and nBnC-HCC patients were larger and higher, respectively, in anti-HBc-positive patients compared with anti-HBc-negative patients, although the difference in nBnC-HCC did not reach statistical significance because of the small numbers. These tumor characteristics were similar to those of B-HCC patients.

CONCLUSION

A possible contribution of prior HBV infection to the development of HCC is indicated.

Authors+Show Affiliations

Department of Gastroenterology, Hepatology and Infectious Disease, Okayama University School of Medicine, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. hironori@cc.okayama-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15946131

Citation

Tanaka, Hironori, et al. "Possible Contribution of Prior Hepatitis B Virus Infection to the Development of Hepatocellular Carcinoma." Journal of Gastroenterology and Hepatology, vol. 20, no. 6, 2005, pp. 850-6.
Tanaka H, Iwasaki Y, Nouso K, et al. Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma. J Gastroenterol Hepatol. 2005;20(6):850-6.
Tanaka, H., Iwasaki, Y., Nouso, K., Kobayashi, Y., Nakamura, S., Matsumoto, E., ... Shiratori, Y. (2005). Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma. Journal of Gastroenterology and Hepatology, 20(6), pp. 850-6.
Tanaka H, et al. Possible Contribution of Prior Hepatitis B Virus Infection to the Development of Hepatocellular Carcinoma. J Gastroenterol Hepatol. 2005;20(6):850-6. PubMed PMID: 15946131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma. AU - Tanaka,Hironori, AU - Iwasaki,Yoshiaki, AU - Nouso,Kazuhiro, AU - Kobayashi,Yoshiyuki, AU - Nakamura,Shin-Ichiro, AU - Matsumoto,Eiji, AU - Toshikuni,Nobuyuki, AU - Kaneyoshi,Toshihiko, AU - Ohsawa,Toshiya, AU - Takaguchi,Kouichi, AU - Fujio,Kozo, AU - Senoh,Tomonori, AU - Ohnishi,Tohru, AU - Sakaguchi,Kohsaku, AU - Shiratori,Yasushi, PY - 2005/6/11/pubmed PY - 2006/5/12/medline PY - 2005/6/11/entrez SP - 850 EP - 6 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 20 IS - 6 N2 - BACKGROUND: The prevalence of prior hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients and its role in hepatocarcinogenesis are not clear. The aim of the present study is to clarify the importance of prior HBV infection in development of HCC. METHODS: Of 1288 consecutive HCC patients between January 1999 and October 2002, 1008 patients were enrolled. To determine the influence of prior HBV infection in hepatitis B surface antigen (HBsAg)-negative HCC, the prevalence of antibody to hepatitis B core antigen (anti-HBc) was examined according to age, and the clinical features were compared between the anti-HBc positive and the negative groups. RESULTS: The proportion of HBsAg-negative HCC patients, HCC patients with antibody to hepatitis C virus (anti-HCV; C-HCC) and HCC patients negative for both HBsAg and anti-HCV (nBnC-HCC), increased with age. The anti-HBc-positive rates in C-HCC patients also increased with age. Those rates in nBnC-HCC patients were >50% in all age groups. Furthermore, it was found that the anti-HBc-positive rates of these patients were higher than those of corresponding control patients. Tumor size and a positive rate for vessel involvement both in C-HCC and nBnC-HCC patients were larger and higher, respectively, in anti-HBc-positive patients compared with anti-HBc-negative patients, although the difference in nBnC-HCC did not reach statistical significance because of the small numbers. These tumor characteristics were similar to those of B-HCC patients. CONCLUSION: A possible contribution of prior HBV infection to the development of HCC is indicated. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/15946131/Possible_contribution_of_prior_hepatitis_B_virus_infection_to_the_development_of_hepatocellular_carcinoma_ L2 - https://doi.org/10.1111/j.1440-1746.2005.03823.x DB - PRIME DP - Unbound Medicine ER -