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The first 5 years of the family clinic for HIV at Tygerberg Hospital: family demographics, survival of children and early impact of antiretroviral therapy.
J Trop Pediatr. 2006 Feb; 52(1):3-11.JT

Abstract

BACKGROUND

Family clinics address the problems of HIV-infected children and their families. The aims were to document demographics of the children and caregivers attending the Family Clinic for HIV at Tygerberg Academic Hospital (TAH) and to investigate factors affecting disease progression in children.

METHODS

A retrospective folder review of children and parents attending the Family Clinic at TAH between January 1997 and December 2001, a period noted for its lack of antiretroviral treatment.

RESULTS

Of 432 children seen for testing, 274 children, median age 16.9 months, were HIV-infected. During follow-up, 46 children died (median age 23 months) and 113 were lost to follow-up. The majority of children were malnourished. Those <2 years of age had lower weight for age Z-scores (WAZ) than older children (p<0.001). At presentation, 47 per cent were in clinical stage B and two-thirds had moderate or severe CD4+ T cell depletion. Seventeen children had received highly active antiretroviral therapy (HAART), 12 dual and 31 monotherapy. HAART was associated with improved survival compared to dual or monotherapy. Risk of death was reduced from eleven-fold for a WAZ <-4 to four-fold between -2 and -3. There was no association with immunological and clinical classification at entry and risk of mortality. Only 18 per cent of parents were evaluated in the clinic. Non-parental care was documented for 25 per cent of families.

CONCLUSIONS

A low WAZ is associated with poor survival in children. Nutritional status should receive more attention in HIV disease classification in children. Parent utilization of the clinic was inadequate. Even in the absence of HAART, extended survival in children is possible.

Authors+Show Affiliations

Amsterdam Medical Center, University of Amsterdam, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

15947012

Citation

van Kooten Niekerk, N K M., et al. "The First 5 Years of the Family Clinic for HIV at Tygerberg Hospital: Family Demographics, Survival of Children and Early Impact of Antiretroviral Therapy." Journal of Tropical Pediatrics, vol. 52, no. 1, 2006, pp. 3-11.
van Kooten Niekerk NK, Knies MM, Howard J, et al. The first 5 years of the family clinic for HIV at Tygerberg Hospital: family demographics, survival of children and early impact of antiretroviral therapy. J Trop Pediatr. 2006;52(1):3-11.
van Kooten Niekerk, N. K., Knies, M. M., Howard, J., Rabie, H., Zeier, M., van Rensburg, A., Frans, N., Schaaf, H. S., Fatti, G., Little, F., & Cotton, M. F. (2006). The first 5 years of the family clinic for HIV at Tygerberg Hospital: family demographics, survival of children and early impact of antiretroviral therapy. Journal of Tropical Pediatrics, 52(1), 3-11.
van Kooten Niekerk NK, et al. The First 5 Years of the Family Clinic for HIV at Tygerberg Hospital: Family Demographics, Survival of Children and Early Impact of Antiretroviral Therapy. J Trop Pediatr. 2006;52(1):3-11. PubMed PMID: 15947012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The first 5 years of the family clinic for HIV at Tygerberg Hospital: family demographics, survival of children and early impact of antiretroviral therapy. AU - van Kooten Niekerk,N K M, AU - Knies,M M, AU - Howard,J, AU - Rabie,H, AU - Zeier,M, AU - van Rensburg,A, AU - Frans,N, AU - Schaaf,H S, AU - Fatti,G, AU - Little,F, AU - Cotton,M F, Y1 - 2005/06/09/ PY - 2005/6/11/pubmed PY - 2006/4/14/medline PY - 2005/6/11/entrez SP - 3 EP - 11 JF - Journal of tropical pediatrics JO - J Trop Pediatr VL - 52 IS - 1 N2 - BACKGROUND: Family clinics address the problems of HIV-infected children and their families. The aims were to document demographics of the children and caregivers attending the Family Clinic for HIV at Tygerberg Academic Hospital (TAH) and to investigate factors affecting disease progression in children. METHODS: A retrospective folder review of children and parents attending the Family Clinic at TAH between January 1997 and December 2001, a period noted for its lack of antiretroviral treatment. RESULTS: Of 432 children seen for testing, 274 children, median age 16.9 months, were HIV-infected. During follow-up, 46 children died (median age 23 months) and 113 were lost to follow-up. The majority of children were malnourished. Those <2 years of age had lower weight for age Z-scores (WAZ) than older children (p<0.001). At presentation, 47 per cent were in clinical stage B and two-thirds had moderate or severe CD4+ T cell depletion. Seventeen children had received highly active antiretroviral therapy (HAART), 12 dual and 31 monotherapy. HAART was associated with improved survival compared to dual or monotherapy. Risk of death was reduced from eleven-fold for a WAZ <-4 to four-fold between -2 and -3. There was no association with immunological and clinical classification at entry and risk of mortality. Only 18 per cent of parents were evaluated in the clinic. Non-parental care was documented for 25 per cent of families. CONCLUSIONS: A low WAZ is associated with poor survival in children. Nutritional status should receive more attention in HIV disease classification in children. Parent utilization of the clinic was inadequate. Even in the absence of HAART, extended survival in children is possible. SN - 0142-6338 UR - https://www.unboundmedicine.com/medline/citation/15947012/The_first_5_years_of_the_family_clinic_for_HIV_at_Tygerberg_Hospital:_family_demographics_survival_of_children_and_early_impact_of_antiretroviral_therapy_ L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/fmi047 DB - PRIME DP - Unbound Medicine ER -