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Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States).

Abstract

OBJECTIVE

Although animal studies suggest an inverse association between consumption of plant foods and risk of colorectal cancer, many observational data have failed to support such an association. We prospectively examined the association between dietary intakes of fruit, vegetables, and fiber and colorectal cancer risk in a large female cohort from the Women's Health Study.

METHODS

Among 39,876 healthy women aged >/=45 years at baseline, 36,976 with baseline self-reported information on dietary intakes and other risk factors for colorectal cancer were included in the analyses. During an average follow-up of 10 years, 223 women were diagnosed with colorectal cancer. Intakes of fruit, vegetables, and fiber were assessed by a baseline food-frequency questionnaire. The analyses were carried out using the Cox proportional hazards regression and all tests were two-sided.

RESULTS

Intakes of fruit, vegetables, and the specific subgroups were not found to be associated with colorectal cancer risk. Multivariate relative risks (RRs) comparing the highest with lowest quintile were 0.79 (95% CI=0.49-1.27,p for trend =0.30) for fruit intake, and 0.88 (95% CI=0.56-1.38,p for trend=0.30) for vegetables intake. Similarly, intake of total fiber was not associated with colorectal cancer risk; the RR for the highest relative to lowest quintile was 0.75 (95% CI=0.48-1.17,p for trend=0.12). However, higher intake of legume fiber was associated with a lower risk of colorectal cancer; the RR for the highest versus slowest quintile was 0.60 (95% CI=0.40-0.91,p for trend=0.02).

CONCLUSIONS

Our data offer little support for associations between intakes of fruit, vegetables, and fiber, and colorectal cancer risk. However, our data suggest that legume fiber and/or other related sources may reduce risk of colorectal cancer.

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  • Authors+Show Affiliations

    ,

    Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. jhlin@rics.bwh.harvard.edu

    , , , , , ,

    Source

    Cancer causes & control : CCC 16:3 2005 Apr pg 225-33

    MeSH

    Colorectal Neoplasms
    Dietary Fiber
    Female
    Fruit
    Humans
    Middle Aged
    Prospective Studies
    Risk Factors
    United States
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15947874

    Citation

    Lin, Jennifer, et al. "Dietary Intakes of Fruit, Vegetables, and Fiber, and Risk of Colorectal Cancer in a Prospective Cohort of Women (United States)." Cancer Causes & Control : CCC, vol. 16, no. 3, 2005, pp. 225-33.
    Lin J, Zhang SM, Cook NR, et al. Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States). Cancer Causes Control. 2005;16(3):225-33.
    Lin, J., Zhang, S. M., Cook, N. R., Rexrode, K. M., Liu, S., Manson, J. E., ... Buring, J. E. (2005). Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States). Cancer Causes & Control : CCC, 16(3), pp. 225-33.
    Lin J, et al. Dietary Intakes of Fruit, Vegetables, and Fiber, and Risk of Colorectal Cancer in a Prospective Cohort of Women (United States). Cancer Causes Control. 2005;16(3):225-33. PubMed PMID: 15947874.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States). AU - Lin,Jennifer, AU - Zhang,Shumin M, AU - Cook,Nancy R, AU - Rexrode,Kathryn M, AU - Liu,Simin, AU - Manson,JoAnn E, AU - Lee,I-Min, AU - Buring,Julie E, PY - 2004/07/17/received PY - 2004/09/30/accepted PY - 2005/6/11/pubmed PY - 2005/10/15/medline PY - 2005/6/11/entrez SP - 225 EP - 33 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 3 N2 - OBJECTIVE: Although animal studies suggest an inverse association between consumption of plant foods and risk of colorectal cancer, many observational data have failed to support such an association. We prospectively examined the association between dietary intakes of fruit, vegetables, and fiber and colorectal cancer risk in a large female cohort from the Women's Health Study. METHODS: Among 39,876 healthy women aged >/=45 years at baseline, 36,976 with baseline self-reported information on dietary intakes and other risk factors for colorectal cancer were included in the analyses. During an average follow-up of 10 years, 223 women were diagnosed with colorectal cancer. Intakes of fruit, vegetables, and fiber were assessed by a baseline food-frequency questionnaire. The analyses were carried out using the Cox proportional hazards regression and all tests were two-sided. RESULTS: Intakes of fruit, vegetables, and the specific subgroups were not found to be associated with colorectal cancer risk. Multivariate relative risks (RRs) comparing the highest with lowest quintile were 0.79 (95% CI=0.49-1.27,p for trend =0.30) for fruit intake, and 0.88 (95% CI=0.56-1.38,p for trend=0.30) for vegetables intake. Similarly, intake of total fiber was not associated with colorectal cancer risk; the RR for the highest relative to lowest quintile was 0.75 (95% CI=0.48-1.17,p for trend=0.12). However, higher intake of legume fiber was associated with a lower risk of colorectal cancer; the RR for the highest versus slowest quintile was 0.60 (95% CI=0.40-0.91,p for trend=0.02). CONCLUSIONS: Our data offer little support for associations between intakes of fruit, vegetables, and fiber, and colorectal cancer risk. However, our data suggest that legume fiber and/or other related sources may reduce risk of colorectal cancer. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/15947874/Dietary_intakes_of_fruit_vegetables_and_fiber_and_risk_of_colorectal_cancer_in_a_prospective_cohort_of_women__United_States__ L2 - https://doi.org/10.1007/s10552-004-4025-1 DB - PRIME DP - Unbound Medicine ER -