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Familial association of prostate cancer with other cancers in the Swedish Family-Cancer Database.
Prostate. 2005 Oct 01; 65(2):188-94.P

Abstract

BACKGROUND

Familial associations between cancer sites may implicate true familial clustering which is relevant for the identification of new cancer syndromes and for clinical counseling.

METHODS

We used the nation-wide Swedish Family-Cancer Database, containing 10,553 sons and 107,518 fathers with prostate cancer among a total of 170,000 cancer patients in the 0- to 70-year-old offspring generation and over 800,000 cancer patients in the parental generation. We calculated familial standardized incidence ratios (SIRs) and confidence intervals (CIs) for prostate cancers and other cancers in family members.

RESULTS

SIRs for prostate cancer were increased in sons when mothers were diagnosed with breast and ovarian cancers, and when siblings were diagnosed with Hodgkins disease (1.78, N = 18, 95% CI 1.05-2.82) and leukemia (1.39, 43, 1.01-1.88). Liver cancer and melanoma were also in excess in the high-risk families.

CONCLUSIONS

The present analysis, the largest yet carried out, found many novel associations implying familial links between prostate cancer and other sites.

Authors+Show Affiliations

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg. K.Hemminki@dkfz.deNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15948149

Citation

Hemminki, Kari, and Bowang Chen. "Familial Association of Prostate Cancer With Other Cancers in the Swedish Family-Cancer Database." The Prostate, vol. 65, no. 2, 2005, pp. 188-94.
Hemminki K, Chen B. Familial association of prostate cancer with other cancers in the Swedish Family-Cancer Database. Prostate. 2005;65(2):188-94.
Hemminki, K., & Chen, B. (2005). Familial association of prostate cancer with other cancers in the Swedish Family-Cancer Database. The Prostate, 65(2), 188-94.
Hemminki K, Chen B. Familial Association of Prostate Cancer With Other Cancers in the Swedish Family-Cancer Database. Prostate. 2005 Oct 1;65(2):188-94. PubMed PMID: 15948149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial association of prostate cancer with other cancers in the Swedish Family-Cancer Database. AU - Hemminki,Kari, AU - Chen,Bowang, PY - 2005/6/11/pubmed PY - 2005/10/26/medline PY - 2005/6/11/entrez SP - 188 EP - 94 JF - The Prostate JO - Prostate VL - 65 IS - 2 N2 - BACKGROUND: Familial associations between cancer sites may implicate true familial clustering which is relevant for the identification of new cancer syndromes and for clinical counseling. METHODS: We used the nation-wide Swedish Family-Cancer Database, containing 10,553 sons and 107,518 fathers with prostate cancer among a total of 170,000 cancer patients in the 0- to 70-year-old offspring generation and over 800,000 cancer patients in the parental generation. We calculated familial standardized incidence ratios (SIRs) and confidence intervals (CIs) for prostate cancers and other cancers in family members. RESULTS: SIRs for prostate cancer were increased in sons when mothers were diagnosed with breast and ovarian cancers, and when siblings were diagnosed with Hodgkins disease (1.78, N = 18, 95% CI 1.05-2.82) and leukemia (1.39, 43, 1.01-1.88). Liver cancer and melanoma were also in excess in the high-risk families. CONCLUSIONS: The present analysis, the largest yet carried out, found many novel associations implying familial links between prostate cancer and other sites. SN - 0270-4137 UR - https://www.unboundmedicine.com/medline/citation/15948149/Familial_association_of_prostate_cancer_with_other_cancers_in_the_Swedish_Family_Cancer_Database_ L2 - https://doi.org/10.1002/pros.20284 DB - PRIME DP - Unbound Medicine ER -