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Screening and preventive behaviors one year after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma.
Cancer 2005; 104(2):273-81C

Abstract

BACKGROUND

Prevention benefits from predictive genetic testing for cancer will only be fully realized if appropriate screening is adopted after testing. The current study assessed screening and preventive behaviors during 12 months after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma (HNPCC) in an Australian clinical cohort.

METHODS

Participants received predictive genetic testing for HNPCC at one of five Australian familial cancer clinics. Data on self-reported screening behaviors (colonoscopy, and endometrial sampling and transvaginal ultrasound for women) and prophylactic surgery (colectomy, and hysterectomy and bilateral oophorectomy for women) were collected using postal questionnaires before (baseline) and 12 months after receipt of genetic test results. Age, gender, perceived risk of cancer, and cancer-specific distress were assessed as predictors of colonoscopic screening.

RESULTS

In the current study, 114 participants returned baseline questionnaires (32 carriers and 82 noncarriers of an HNPCC mutation). Ninety-eight participants also returned a 12-month follow-up questionnaire. Of those > or = 25 years, 73% reported having had a colonoscopy before genetic testing. At follow-up, 71% (15 of 25) of carriers and 12% (8 of 65) of noncarriers reported having a colonoscopy in the 12 months after receipt of test results. The reduction in colonoscopy among noncarriers was statistically significant (P < 0.001). High perceived risk was associated with colonoscopy at baseline. At follow-up, mutation status was the only variable significantly associated with colonoscopy. Among female mutation carriers, 47% reported having transvaginal ultrasonography and 53% endometrial sampling during follow-up. There was low uptake of prophylactic surgery for colorectal, endometrial, or ovarian carcinomas.

CONCLUSIONS

The majority of individuals reported appropriate screening behaviors after predictive genetic testing for HNPCC. The small group of noncarriers who had screening after genetic testing might benefit from additional counseling.

Authors+Show Affiliations

Public Health Genetics, Murdoch Childrens Research Institute, Parkville, Victoria, Australia. veronica.collins@mcri.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15948171

Citation

Collins, Veronica, et al. "Screening and Preventive Behaviors One Year After Predictive Genetic Testing for Hereditary Nonpolyposis Colorectal Carcinoma." Cancer, vol. 104, no. 2, 2005, pp. 273-81.
Collins V, Meiser B, Gaff C, et al. Screening and preventive behaviors one year after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma. Cancer. 2005;104(2):273-81.
Collins, V., Meiser, B., Gaff, C., St John, D. J., & Halliday, J. (2005). Screening and preventive behaviors one year after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma. Cancer, 104(2), pp. 273-81.
Collins V, et al. Screening and Preventive Behaviors One Year After Predictive Genetic Testing for Hereditary Nonpolyposis Colorectal Carcinoma. Cancer. 2005 Jul 15;104(2):273-81. PubMed PMID: 15948171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening and preventive behaviors one year after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma. AU - Collins,Veronica, AU - Meiser,Bettina, AU - Gaff,Clara, AU - St John,D James B, AU - Halliday,Jane, PY - 2005/6/11/pubmed PY - 2005/9/24/medline PY - 2005/6/11/entrez SP - 273 EP - 81 JF - Cancer JO - Cancer VL - 104 IS - 2 N2 - BACKGROUND: Prevention benefits from predictive genetic testing for cancer will only be fully realized if appropriate screening is adopted after testing. The current study assessed screening and preventive behaviors during 12 months after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma (HNPCC) in an Australian clinical cohort. METHODS: Participants received predictive genetic testing for HNPCC at one of five Australian familial cancer clinics. Data on self-reported screening behaviors (colonoscopy, and endometrial sampling and transvaginal ultrasound for women) and prophylactic surgery (colectomy, and hysterectomy and bilateral oophorectomy for women) were collected using postal questionnaires before (baseline) and 12 months after receipt of genetic test results. Age, gender, perceived risk of cancer, and cancer-specific distress were assessed as predictors of colonoscopic screening. RESULTS: In the current study, 114 participants returned baseline questionnaires (32 carriers and 82 noncarriers of an HNPCC mutation). Ninety-eight participants also returned a 12-month follow-up questionnaire. Of those > or = 25 years, 73% reported having had a colonoscopy before genetic testing. At follow-up, 71% (15 of 25) of carriers and 12% (8 of 65) of noncarriers reported having a colonoscopy in the 12 months after receipt of test results. The reduction in colonoscopy among noncarriers was statistically significant (P < 0.001). High perceived risk was associated with colonoscopy at baseline. At follow-up, mutation status was the only variable significantly associated with colonoscopy. Among female mutation carriers, 47% reported having transvaginal ultrasonography and 53% endometrial sampling during follow-up. There was low uptake of prophylactic surgery for colorectal, endometrial, or ovarian carcinomas. CONCLUSIONS: The majority of individuals reported appropriate screening behaviors after predictive genetic testing for HNPCC. The small group of noncarriers who had screening after genetic testing might benefit from additional counseling. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/15948171/Screening_and_preventive_behaviors_one_year_after_predictive_genetic_testing_for_hereditary_nonpolyposis_colorectal_carcinoma_ L2 - https://doi.org/10.1002/cncr.21183 DB - PRIME DP - Unbound Medicine ER -