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Postprandial oesophageal integrated acidity is a reliable predictor of gastro-oesophageal reflux disease.
Aliment Pharmacol Ther 2005; 21(12):1475-82AP

Abstract

BACKGROUND

Measurement of oesophageal acid exposure parameters postprandially has been shown to distinguish gastro-oesophageal reflux disease patients from normal individuals.

AIMS

To calculate the accuracy of postprandial oesophageal integrated acidity in diagnosing gastro-oesophageal reflux disease.

METHODS

Ambulatory 24-h pH studies of 626 patients were analysed retrospectively. Gastro-oesophageal reflux disease, defined as pH < 4 for > 4.2% of time, was identified in 305 subjects. Postprandial oesophageal integrated acidity was measured for 2 and 3 h after the largest meal peak as determined from gastric pH. Postprandial symptom-associated probability was calculated.

RESULTS

Gastro-oesophageal reflux disease subjects had a greater postprandial oesophageal integrated acidity than non-gastro-oesophageal reflux disease subjects [median (IQR): 0.57 (0.08-2.66) vs. 0.03 (0.01-0.15) mmol*h/L]. Median postprandial oesophageal integrated acidity did not differ with gender or age in gastro-oesophageal reflux disease and non-gastro-oesophageal reflux disease subjects (P > 0.05 for all). A 3-h postprandial oesophageal integrated acidity value of 0.121 mmol*h/L had a 71.1% sensitivity and 71.7% specificity in diagnosing gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease subjects with symptoms had a higher postprandial oesophageal integrated acidity than those without (P = 0.043), whereas non-gastro-oesophageal reflux disease subjects with and without symptoms did not differ (P = 0.74). The correlation between symptom-associated probability and postprandial oesophageal integrated acidity was poor (gastro-oesophageal reflux disease: r = 0.15; non-gastro-oesophageal reflux disease: r = 0.25).

CONCLUSION

Postprandial oesophageal integrated acidity provides a robust estimation of oesophageal acid exposure and may predict symptoms in gastro-oesophageal reflux disease patients.

Authors+Show Affiliations

Division of Gastroenterology, University of Pennsylvania Health Systems, Philadelphia, PA 19104, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

15948815

Citation

Shih, G L., et al. "Postprandial Oesophageal Integrated Acidity Is a Reliable Predictor of Gastro-oesophageal Reflux Disease." Alimentary Pharmacology & Therapeutics, vol. 21, no. 12, 2005, pp. 1475-82.
Shih GL, Brensinger CM, Katzka DA, et al. Postprandial oesophageal integrated acidity is a reliable predictor of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2005;21(12):1475-82.
Shih, G. L., Brensinger, C. M., Katzka, D. A., & Metz, D. C. (2005). Postprandial oesophageal integrated acidity is a reliable predictor of gastro-oesophageal reflux disease. Alimentary Pharmacology & Therapeutics, 21(12), pp. 1475-82.
Shih GL, et al. Postprandial Oesophageal Integrated Acidity Is a Reliable Predictor of Gastro-oesophageal Reflux Disease. Aliment Pharmacol Ther. 2005 Jun 15;21(12):1475-82. PubMed PMID: 15948815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial oesophageal integrated acidity is a reliable predictor of gastro-oesophageal reflux disease. AU - Shih,G L, AU - Brensinger,C M, AU - Katzka,D A, AU - Metz,D C, PY - 2005/6/14/pubmed PY - 2005/9/30/medline PY - 2005/6/14/entrez SP - 1475 EP - 82 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 21 IS - 12 N2 - BACKGROUND: Measurement of oesophageal acid exposure parameters postprandially has been shown to distinguish gastro-oesophageal reflux disease patients from normal individuals. AIMS: To calculate the accuracy of postprandial oesophageal integrated acidity in diagnosing gastro-oesophageal reflux disease. METHODS: Ambulatory 24-h pH studies of 626 patients were analysed retrospectively. Gastro-oesophageal reflux disease, defined as pH < 4 for > 4.2% of time, was identified in 305 subjects. Postprandial oesophageal integrated acidity was measured for 2 and 3 h after the largest meal peak as determined from gastric pH. Postprandial symptom-associated probability was calculated. RESULTS: Gastro-oesophageal reflux disease subjects had a greater postprandial oesophageal integrated acidity than non-gastro-oesophageal reflux disease subjects [median (IQR): 0.57 (0.08-2.66) vs. 0.03 (0.01-0.15) mmol*h/L]. Median postprandial oesophageal integrated acidity did not differ with gender or age in gastro-oesophageal reflux disease and non-gastro-oesophageal reflux disease subjects (P > 0.05 for all). A 3-h postprandial oesophageal integrated acidity value of 0.121 mmol*h/L had a 71.1% sensitivity and 71.7% specificity in diagnosing gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease subjects with symptoms had a higher postprandial oesophageal integrated acidity than those without (P = 0.043), whereas non-gastro-oesophageal reflux disease subjects with and without symptoms did not differ (P = 0.74). The correlation between symptom-associated probability and postprandial oesophageal integrated acidity was poor (gastro-oesophageal reflux disease: r = 0.15; non-gastro-oesophageal reflux disease: r = 0.25). CONCLUSION: Postprandial oesophageal integrated acidity provides a robust estimation of oesophageal acid exposure and may predict symptoms in gastro-oesophageal reflux disease patients. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15948815/Postprandial_oesophageal_integrated_acidity_is_a_reliable_predictor_of_gastro_oesophageal_reflux_disease_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02509.x DB - PRIME DP - Unbound Medicine ER -