Tags

Type your tag names separated by a space and hit enter

Amino acid-dependent modulation of glucose metabolism in humans.
Eur J Clin Invest 2005; 35(6):351-4EJ

Abstract

Despite its high prevalence and severe complications, the aetiology of the primary defects leading to Type 2 diabetes mellitus remain unknown. In addition to polygenic predisposition, environmental factors including dietary behaviour are increasingly recognized as being of crucial importance for the development of this disease. This strongly supports the concept that nutrient excess leading to increased availability of substrates adversely influences whole-body metabolic regulation and plays a major role in the development of type 2 diabetes. We have shown previously that a short-term increase in free fatty acid availability impairs glucose metabolism in liver and skeletal muscle. Despite the widespread interest in protein-rich diets, the effects of plasma amino acid elevation on human glucose metabolism have not yet been studied in detail. This editorial summarizes recent advances in the identification of mechanisms responsible for amino acid-dependent modulation of glucose metabolism in liver and skeletal muscle in vivo.

Authors

No affiliation info available

Pub Type(s)

Editorial

Language

eng

PubMed ID

15948894

Citation

Krebs, M. "Amino Acid-dependent Modulation of Glucose Metabolism in Humans." European Journal of Clinical Investigation, vol. 35, no. 6, 2005, pp. 351-4.
Krebs M. Amino acid-dependent modulation of glucose metabolism in humans. Eur J Clin Invest. 2005;35(6):351-4.
Krebs, M. (2005). Amino acid-dependent modulation of glucose metabolism in humans. European Journal of Clinical Investigation, 35(6), pp. 351-4.
Krebs M. Amino Acid-dependent Modulation of Glucose Metabolism in Humans. Eur J Clin Invest. 2005;35(6):351-4. PubMed PMID: 15948894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amino acid-dependent modulation of glucose metabolism in humans. A1 - Krebs,M, PY - 2005/6/14/pubmed PY - 2005/9/21/medline PY - 2005/6/14/entrez SP - 351 EP - 4 JF - European journal of clinical investigation JO - Eur. J. Clin. Invest. VL - 35 IS - 6 N2 - Despite its high prevalence and severe complications, the aetiology of the primary defects leading to Type 2 diabetes mellitus remain unknown. In addition to polygenic predisposition, environmental factors including dietary behaviour are increasingly recognized as being of crucial importance for the development of this disease. This strongly supports the concept that nutrient excess leading to increased availability of substrates adversely influences whole-body metabolic regulation and plays a major role in the development of type 2 diabetes. We have shown previously that a short-term increase in free fatty acid availability impairs glucose metabolism in liver and skeletal muscle. Despite the widespread interest in protein-rich diets, the effects of plasma amino acid elevation on human glucose metabolism have not yet been studied in detail. This editorial summarizes recent advances in the identification of mechanisms responsible for amino acid-dependent modulation of glucose metabolism in liver and skeletal muscle in vivo. SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/15948894/full_citation L2 - https://doi.org/10.1111/j.1365-2362.2005.01506.x DB - PRIME DP - Unbound Medicine ER -