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Air flow at different temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo.
Br J Dermatol. 2005 Jun; 152(6):1228-34.BJ

Abstract

BACKGROUND

Combined exposure to dry climatic conditions and local heat sources together with detergents represents a common workplace situation. These conditions may support the induction of chronic barrier disruption leading subsequently to irritant contact dermatitis (ICD).

OBJECTIVES

To test the irritant and barrier disrupting properties of air flow at different temperatures and velocities.

METHODS

Using noninvasive biophysical measurements such as transepidermal water loss (TEWL) (TM 210; Courage & Khazaka, Cologne, Germany) we assessed the effects of short-term exposure to air flow at different temperatures (24 degrees C and 43 degrees C) in combination with sodium lauryl sulphate (SLS) 0.5% on the skin of 20 healthy volunteers in a tandem repeated irritation test. Chromametry was used to control the accuracy of the SLS irritation model.

RESULTS

In our study air flow alone did not lead to a significant increase in TEWL values. Sequential treatment with air flow and SLS led to an impairment of barrier function and irritation stronger than that produced by SLS alone. The two different air flow temperatures led to different skin temperatures but had no influence on permeability barrier function.

CONCLUSIONS

Warm air flow has an additional effect on the SLS-induced barrier disruption in a tandem irritation test with sequential exposure to SLS/air flow. This combination is suspected to promote ICD in workplace and household situations, especially in short-term applications as tested in our model.

Authors+Show Affiliations

Skin Physiology Laboratory, Department of Dermatology, Friedrich-Schiller-University, Erfurter Str. 35, 07740 Jena, Germany. Fluhr@derma.uni-jena.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15948986

Citation

Fluhr, J W., et al. "Air Flow at Different Temperatures Increases Sodium Lauryl Sulphate-induced Barrier Disruption and Irritation in Vivo." The British Journal of Dermatology, vol. 152, no. 6, 2005, pp. 1228-34.
Fluhr JW, Praessler J, Akengin A, et al. Air flow at different temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo. Br J Dermatol. 2005;152(6):1228-34.
Fluhr, J. W., Praessler, J., Akengin, A., Fuchs, S. M., Kleesz, P., Grieshaber, R., & Elsner, P. (2005). Air flow at different temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo. The British Journal of Dermatology, 152(6), 1228-34.
Fluhr JW, et al. Air Flow at Different Temperatures Increases Sodium Lauryl Sulphate-induced Barrier Disruption and Irritation in Vivo. Br J Dermatol. 2005;152(6):1228-34. PubMed PMID: 15948986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Air flow at different temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo. AU - Fluhr,J W, AU - Praessler,J, AU - Akengin,A, AU - Fuchs,S M, AU - Kleesz,P, AU - Grieshaber,R, AU - Elsner,P, PY - 2005/6/14/pubmed PY - 2005/8/5/medline PY - 2005/6/14/entrez SP - 1228 EP - 34 JF - The British journal of dermatology JO - Br J Dermatol VL - 152 IS - 6 N2 - BACKGROUND: Combined exposure to dry climatic conditions and local heat sources together with detergents represents a common workplace situation. These conditions may support the induction of chronic barrier disruption leading subsequently to irritant contact dermatitis (ICD). OBJECTIVES: To test the irritant and barrier disrupting properties of air flow at different temperatures and velocities. METHODS: Using noninvasive biophysical measurements such as transepidermal water loss (TEWL) (TM 210; Courage & Khazaka, Cologne, Germany) we assessed the effects of short-term exposure to air flow at different temperatures (24 degrees C and 43 degrees C) in combination with sodium lauryl sulphate (SLS) 0.5% on the skin of 20 healthy volunteers in a tandem repeated irritation test. Chromametry was used to control the accuracy of the SLS irritation model. RESULTS: In our study air flow alone did not lead to a significant increase in TEWL values. Sequential treatment with air flow and SLS led to an impairment of barrier function and irritation stronger than that produced by SLS alone. The two different air flow temperatures led to different skin temperatures but had no influence on permeability barrier function. CONCLUSIONS: Warm air flow has an additional effect on the SLS-induced barrier disruption in a tandem irritation test with sequential exposure to SLS/air flow. This combination is suspected to promote ICD in workplace and household situations, especially in short-term applications as tested in our model. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/15948986/Air_flow_at_different_temperatures_increases_sodium_lauryl_sulphate_induced_barrier_disruption_and_irritation_in_vivo_ L2 - https://doi.org/10.1111/j.1365-2133.2005.06531.x DB - PRIME DP - Unbound Medicine ER -