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In vitro evaluation of concurrent use of commercially available insect repellent and sunscreen preparations.
Br J Dermatol. 2005 Jun; 152(6):1263-7.BJ

Abstract

BACKGROUND

Insect repellents and sunscreens are over-the-counter products extensively used by the general public. Concurrent application of these products has become widespread in many regions across North America, because of concerns about West Nile virus and skin cancers.

OBJECTIVES

We investigated whether formulation type, application amount, and sequence would affect the percutaneous absorption profiles of the active repellent and sunscreen ingredients.

METHODS

In vitro percutaneous permeation of the repellent N,N-diethyl-m-toluamide (DEET) and the sunscreen oxybenzone from concurrent application of five commercially available products (A, repellent spray; B, repellent lotion; C, sunscreen lotion; D and E, combined repellent/sunscreen lotions) was measured and compared using Franz-style diffusion cells with piglet skin at 37 degrees C.

RESULTS

Penetration of DEET in A and B increased by 1640% and 282%, respectively, when C was applied concurrently. Penetration of DEET in D and E was 53% and 79% higher than that in B. Permeation of DEET from A + C (2:1) and A + C (1: 2) increased by 530% and 278%, respectively. Permeation of oxybenzone was 189% and 280% higher in A + C and B + C than in C. Permeation of oxybenzone in D and E was also 221% and 296% higher than that in C. Permeation of oxybenzone was 196% greater when A was applied on top of C than when C was applied on top of A, while oxybenzone in A + C (1:2) permeated 171% more than that in A + C (2:1).

CONCLUSIONS

Concurrent application of commercially available repellent and sunscreen products resulted in significant synergistic percutaneous permeation of the repellent DEET and the sunscreen oxybenzone in vitro. The percutaneous penetration profiles were dependent upon the type of formulation, application sequence and application proportion.

Authors+Show Affiliations

Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada. xgu@cc.umanitoba.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15948991

Citation

Gu, X, et al. "In Vitro Evaluation of Concurrent Use of Commercially Available Insect Repellent and Sunscreen Preparations." The British Journal of Dermatology, vol. 152, no. 6, 2005, pp. 1263-7.
Gu X, Wang T, Collins DM, et al. In vitro evaluation of concurrent use of commercially available insect repellent and sunscreen preparations. Br J Dermatol. 2005;152(6):1263-7.
Gu, X., Wang, T., Collins, D. M., Kasichayanula, S., & Burczynski, F. J. (2005). In vitro evaluation of concurrent use of commercially available insect repellent and sunscreen preparations. The British Journal of Dermatology, 152(6), 1263-7.
Gu X, et al. In Vitro Evaluation of Concurrent Use of Commercially Available Insect Repellent and Sunscreen Preparations. Br J Dermatol. 2005;152(6):1263-7. PubMed PMID: 15948991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro evaluation of concurrent use of commercially available insect repellent and sunscreen preparations. AU - Gu,X, AU - Wang,T, AU - Collins,D M, AU - Kasichayanula,S, AU - Burczynski,F J, PY - 2005/6/14/pubmed PY - 2005/8/5/medline PY - 2005/6/14/entrez SP - 1263 EP - 7 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 152 IS - 6 N2 - BACKGROUND: Insect repellents and sunscreens are over-the-counter products extensively used by the general public. Concurrent application of these products has become widespread in many regions across North America, because of concerns about West Nile virus and skin cancers. OBJECTIVES: We investigated whether formulation type, application amount, and sequence would affect the percutaneous absorption profiles of the active repellent and sunscreen ingredients. METHODS: In vitro percutaneous permeation of the repellent N,N-diethyl-m-toluamide (DEET) and the sunscreen oxybenzone from concurrent application of five commercially available products (A, repellent spray; B, repellent lotion; C, sunscreen lotion; D and E, combined repellent/sunscreen lotions) was measured and compared using Franz-style diffusion cells with piglet skin at 37 degrees C. RESULTS: Penetration of DEET in A and B increased by 1640% and 282%, respectively, when C was applied concurrently. Penetration of DEET in D and E was 53% and 79% higher than that in B. Permeation of DEET from A + C (2:1) and A + C (1: 2) increased by 530% and 278%, respectively. Permeation of oxybenzone was 189% and 280% higher in A + C and B + C than in C. Permeation of oxybenzone in D and E was also 221% and 296% higher than that in C. Permeation of oxybenzone was 196% greater when A was applied on top of C than when C was applied on top of A, while oxybenzone in A + C (1:2) permeated 171% more than that in A + C (2:1). CONCLUSIONS: Concurrent application of commercially available repellent and sunscreen products resulted in significant synergistic percutaneous permeation of the repellent DEET and the sunscreen oxybenzone in vitro. The percutaneous penetration profiles were dependent upon the type of formulation, application sequence and application proportion. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/15948991/full_citation L2 - https://doi.org/10.1111/j.1365-2133.2005.06691.x DB - PRIME DP - Unbound Medicine ER -