Tags

Type your tag names separated by a space and hit enter

HbA1c predicts the likelihood of having impaired glucose tolerance in high-risk patients with normal fasting plasma glucose.
Ann Clin Biochem. 2005 May; 42(Pt 3):193-5.AC

Abstract

BACKGROUND

Although the oral glucose tolerance test (OGTT) is the 'gold standard' for diagnosing prediabetes/diabetes, it is inconvenient for the patient and time consuming. The only alternative simple screening test is fasting plasma glucose (FPG). FPG concentrations of > 6.0 mmol/L represent prediabetes/diabetes. FPG concentrations of < or = 6.0 mmol/L may be considered 'normal', although some such patients will demonstrate abnormal glucose tolerance when subjected to an OGTT. We have evaluated the use of glycated haemoglobin (HbA1c) as a screening test for diabetes or impaired glucose tolerance (IGT) in patients who have risk factors for diabetes but FPG < or = 6.0 mmol/L.

METHODS AND RESULTS

A total of 580 patients with at least two risk factors for diabetes underwent an OGTT and HbA1c measurement. In all, 225 patients had a FPG < or = 6.0 mmol/L and met the inclusion criteria. Of these, 23.1% (n=52) had an abnormal OGTT result (45 had IGT and 7 had diabetes). Subjects with abnormal glucose tolerance had a higher percentage of HbA1c than subjects with normal glucose tolerance (P<0.001). An HbA1c of 5.6% gave an optimal sensitivity of 72% and specificity of 77% to predict a 2 h plasma glucose > or = 7.8 mmol/L.

CONCLUSION

The use of FPG concentration followed by selective measurement of HbA1c in patients who are at high risk of developing diabetes may represent a reasonable approach to identifying patients requiring an OGTT.

Authors+Show Affiliations

Department of Clinical Biochemistry, Russells Hall Hospital, Dudley, West Midlands DY1 2HQ, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15949153

Citation

Geberhiwot, Tarekegn, et al. "HbA1c Predicts the Likelihood of Having Impaired Glucose Tolerance in High-risk Patients With Normal Fasting Plasma Glucose." Annals of Clinical Biochemistry, vol. 42, no. Pt 3, 2005, pp. 193-5.
Geberhiwot T, Haddon A, Labib M. HbA1c predicts the likelihood of having impaired glucose tolerance in high-risk patients with normal fasting plasma glucose. Ann Clin Biochem. 2005;42(Pt 3):193-5.
Geberhiwot, T., Haddon, A., & Labib, M. (2005). HbA1c predicts the likelihood of having impaired glucose tolerance in high-risk patients with normal fasting plasma glucose. Annals of Clinical Biochemistry, 42(Pt 3), 193-5.
Geberhiwot T, Haddon A, Labib M. HbA1c Predicts the Likelihood of Having Impaired Glucose Tolerance in High-risk Patients With Normal Fasting Plasma Glucose. Ann Clin Biochem. 2005;42(Pt 3):193-5. PubMed PMID: 15949153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HbA1c predicts the likelihood of having impaired glucose tolerance in high-risk patients with normal fasting plasma glucose. AU - Geberhiwot,Tarekegn, AU - Haddon,Angela, AU - Labib,Mourad, PY - 2005/6/14/pubmed PY - 2005/8/12/medline PY - 2005/6/14/entrez SP - 193 EP - 5 JF - Annals of clinical biochemistry JO - Ann Clin Biochem VL - 42 IS - Pt 3 N2 - BACKGROUND: Although the oral glucose tolerance test (OGTT) is the 'gold standard' for diagnosing prediabetes/diabetes, it is inconvenient for the patient and time consuming. The only alternative simple screening test is fasting plasma glucose (FPG). FPG concentrations of > 6.0 mmol/L represent prediabetes/diabetes. FPG concentrations of < or = 6.0 mmol/L may be considered 'normal', although some such patients will demonstrate abnormal glucose tolerance when subjected to an OGTT. We have evaluated the use of glycated haemoglobin (HbA1c) as a screening test for diabetes or impaired glucose tolerance (IGT) in patients who have risk factors for diabetes but FPG < or = 6.0 mmol/L. METHODS AND RESULTS: A total of 580 patients with at least two risk factors for diabetes underwent an OGTT and HbA1c measurement. In all, 225 patients had a FPG < or = 6.0 mmol/L and met the inclusion criteria. Of these, 23.1% (n=52) had an abnormal OGTT result (45 had IGT and 7 had diabetes). Subjects with abnormal glucose tolerance had a higher percentage of HbA1c than subjects with normal glucose tolerance (P<0.001). An HbA1c of 5.6% gave an optimal sensitivity of 72% and specificity of 77% to predict a 2 h plasma glucose > or = 7.8 mmol/L. CONCLUSION: The use of FPG concentration followed by selective measurement of HbA1c in patients who are at high risk of developing diabetes may represent a reasonable approach to identifying patients requiring an OGTT. SN - 0004-5632 UR - https://www.unboundmedicine.com/medline/citation/15949153/HbA1c_predicts_the_likelihood_of_having_impaired_glucose_tolerance_in_high_risk_patients_with_normal_fasting_plasma_glucose_ L2 - https://journals.sagepub.com/doi/10.1258/0004563053857950?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -