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Somatization: a psychoneuroimmune perspective.
Psychoneuroendocrinology. 2005 Nov; 30(10):947-52.P

Abstract

The concept of somatization has a long history in psychosomatic medicine. What is missing, however, is an understanding of the way patients are able to perceive and represent somatic symptoms. Recent advances in psychoneuroimmunology offer new perspectives in this area. Proinflammatory cytokines produced by cells of the innate immune system in response to pathogen-associated molecular patterns and to endogenous danger signals act on the central nervous system via afferent and humoral pathways to trigger a brain cytokine system that organizes the sickness response in its subjective, behavioral, and metabolic components. There is evidence that prolonged activation of this system can precipitate the development of depressive disorders in vulnerable patients. The mechanisms that are responsible for the transition from sickness to depression involve alterations in tryptophan metabolism. There is also some indication that the brain cytokine system can become sensitized in response to non-immune stressors or to immune stressors occurring early in life. All these new findings have the potential to contribute to a renewed biopsychological approach to somatization and somatoform disorders.

Authors+Show Affiliations

Neurobiologie intégrative, CNRS-INRA-Université de Bordeaux 2, Institut François Magendie, 33077 Bordeaux Cedex, France. robert.dantzer@bordeaux.inserm.fr

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15949897

Citation

Dantzer, Robert. "Somatization: a Psychoneuroimmune Perspective." Psychoneuroendocrinology, vol. 30, no. 10, 2005, pp. 947-52.
Dantzer R. Somatization: a psychoneuroimmune perspective. Psychoneuroendocrinology. 2005;30(10):947-52.
Dantzer, R. (2005). Somatization: a psychoneuroimmune perspective. Psychoneuroendocrinology, 30(10), 947-52.
Dantzer R. Somatization: a Psychoneuroimmune Perspective. Psychoneuroendocrinology. 2005;30(10):947-52. PubMed PMID: 15949897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatization: a psychoneuroimmune perspective. A1 - Dantzer,Robert, PY - 2004/08/18/received PY - 2005/03/21/accepted PY - 2005/6/14/pubmed PY - 2005/10/5/medline PY - 2005/6/14/entrez SP - 947 EP - 52 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 30 IS - 10 N2 - The concept of somatization has a long history in psychosomatic medicine. What is missing, however, is an understanding of the way patients are able to perceive and represent somatic symptoms. Recent advances in psychoneuroimmunology offer new perspectives in this area. Proinflammatory cytokines produced by cells of the innate immune system in response to pathogen-associated molecular patterns and to endogenous danger signals act on the central nervous system via afferent and humoral pathways to trigger a brain cytokine system that organizes the sickness response in its subjective, behavioral, and metabolic components. There is evidence that prolonged activation of this system can precipitate the development of depressive disorders in vulnerable patients. The mechanisms that are responsible for the transition from sickness to depression involve alterations in tryptophan metabolism. There is also some indication that the brain cytokine system can become sensitized in response to non-immune stressors or to immune stressors occurring early in life. All these new findings have the potential to contribute to a renewed biopsychological approach to somatization and somatoform disorders. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/15949897/Somatization:_a_psychoneuroimmune_perspective_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(05)00087-9 DB - PRIME DP - Unbound Medicine ER -