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Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes.
Am J Cardiol. 2005 Jun 15; 95(12):1420-4.AJ

Abstract

A high plasma homocysteine level is associated with early onset of coronary artery disease (CAD), particularly in homozygotes for the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene. Family history is a predictor of increased plasma homocysteine and may be involved in early-onset CAD. This study examined the relations among family history, plasma homocysteine, and age at onset of CAD, and the role of the MTHFR genotype in this context. We screened 284 patients who developed first symptoms of CAD at < or =65 years of age for fasting plasma homocysteine and the C677T mutation. On multiple regression analysis, homocysteine, family history, male gender, and smoking were independently associated with age at onset of CAD. However, separate analysis of patients who had the MTHFR 677 T/T genotype (n = 57) and those who did not (n = 209) showed that plasma homocysteine and family history were associated with earlier onset of CAD only in T/T homozygotes and that family history in patients who had this genotype was also associated with higher plasma homocysteine levels and a stronger association between plasma homocysteine and age at onset of CAD. In patients who had other genotypes, these associations were not observed, and earlier onset of CAD was associated only with male gender and smoking. Thus, the MTHFR genotype modifies the effects of family history and other risk factors on age at onset of CAD. In T/T homozygotes, family history is associated with earlier onset of CAD, higher plasma homocysteine levels, and a stronger association between plasma homocysteine and age at onset of CAD.

Authors+Show Affiliations

Department of Cardiology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel. mager@netvision.net.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15950563

Citation

Mager, Aviv, et al. "Family History, Plasma Homocysteine, and Age at Onset of Symptoms of Myocardial Ischemia in Patients With Different Methylenetetrahydrofolate Reductase Genotypes." The American Journal of Cardiology, vol. 95, no. 12, 2005, pp. 1420-4.
Mager A, Koren-Morag N, Shohat M, et al. Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes. Am J Cardiol. 2005;95(12):1420-4.
Mager, A., Koren-Morag, N., Shohat, M., Harell, D., & Battler, A. (2005). Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes. The American Journal of Cardiology, 95(12), 1420-4.
Mager A, et al. Family History, Plasma Homocysteine, and Age at Onset of Symptoms of Myocardial Ischemia in Patients With Different Methylenetetrahydrofolate Reductase Genotypes. Am J Cardiol. 2005 Jun 15;95(12):1420-4. PubMed PMID: 15950563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes. AU - Mager,Aviv, AU - Koren-Morag,Nira, AU - Shohat,Mordechai, AU - Harell,Daniella, AU - Battler,Alexander, PY - 2004/10/05/received PY - 2005/01/31/revised PY - 2005/01/28/accepted PY - 2005/6/14/pubmed PY - 2005/8/27/medline PY - 2005/6/14/entrez SP - 1420 EP - 4 JF - The American journal of cardiology JO - Am J Cardiol VL - 95 IS - 12 N2 - A high plasma homocysteine level is associated with early onset of coronary artery disease (CAD), particularly in homozygotes for the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene. Family history is a predictor of increased plasma homocysteine and may be involved in early-onset CAD. This study examined the relations among family history, plasma homocysteine, and age at onset of CAD, and the role of the MTHFR genotype in this context. We screened 284 patients who developed first symptoms of CAD at < or =65 years of age for fasting plasma homocysteine and the C677T mutation. On multiple regression analysis, homocysteine, family history, male gender, and smoking were independently associated with age at onset of CAD. However, separate analysis of patients who had the MTHFR 677 T/T genotype (n = 57) and those who did not (n = 209) showed that plasma homocysteine and family history were associated with earlier onset of CAD only in T/T homozygotes and that family history in patients who had this genotype was also associated with higher plasma homocysteine levels and a stronger association between plasma homocysteine and age at onset of CAD. In patients who had other genotypes, these associations were not observed, and earlier onset of CAD was associated only with male gender and smoking. Thus, the MTHFR genotype modifies the effects of family history and other risk factors on age at onset of CAD. In T/T homozygotes, family history is associated with earlier onset of CAD, higher plasma homocysteine levels, and a stronger association between plasma homocysteine and age at onset of CAD. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/15950563/Family_history_plasma_homocysteine_and_age_at_onset_of_symptoms_of_myocardial_ischemia_in_patients_with_different_methylenetetrahydrofolate_reductase_genotypes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(05)00464-9 DB - PRIME DP - Unbound Medicine ER -