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Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome.

Abstract

OBJECTIVE

To determine plasma adiponectin concentration in women with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adiponectin to the hormonal and metabolic parameters, including measures of insulin resistance (IR).

DESIGN

Case-control study.

SETTING

Tertiary-referral university hospital.

PATIENT(S)

One hundred eighty selected women were classified as follows: 45 obese (body mass index [BMI] >30 kg/m2) with PCOS; 45 lean (BMI <25 kg/m2) with PCOS; 45 obese (BMI >30 kg/m2) without PCOS, and 45 lean (BMI <25 kg/m2) without PCOS.

INTERVENTION(S)

Blood samples were collected from all women with or without PCOS between 8 and 11 am, after an overnight fast.

MAIN OUTCOME MEASURE(S)

Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), free T4, testosterone (T), 17-alpha-hydroxyprogesterone, Delta4-androstenedione (Delta4-A), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), insulin, and plasma levels of adiponectin and glucose. Measures of IR included fasting serum insulin, glucose-to-insulin ratio, and homeostasis model assessment (HOMA).

RESULT(S)

Adiponectin concentrations were found to be significantly decreased in women with PCOS and in obese women without PCOS as compared with lean women without PCOS. Adiponectin concentrations correlated inversely with body weight, BMI, fasting plasma glucose, serum insulin, Delta4-A, DHEA, DHEAS, and HOMA but correlated positively with serum T, SHBG, FAI, and glucose-to-insulin ratio. Multiple regression analysis showed that BMI, HOMA, Delta4-A, and insulin were independent determinants of adiponectin concentrations.

CONCLUSION(S)

Hypoadiponectinemia is evident in obese and lean women with PCOS with variable degree of IR; and it is suggested that IR per se or other metabolic abnormalities of PCOS are involved in the regulation of adiponectin concentration in women with PCOS.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. ardawims@yahoo.com

    Source

    Fertility and sterility 83:6 2005 Jun pg 1708-16

    MeSH

    Adiponectin
    Adult
    Blood Glucose
    Body Mass Index
    Case-Control Studies
    Chi-Square Distribution
    Confidence Intervals
    Female
    Humans
    Insulin Resistance
    Obesity
    Polycystic Ovary Syndrome

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15950640

    Citation

    Ardawi, Mohammed Salleh M., and Abdulrahim A. Rouzi. "Plasma Adiponectin and Insulin Resistance in Women With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 83, no. 6, 2005, pp. 1708-16.
    Ardawi MS, Rouzi AA. Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 2005;83(6):1708-16.
    Ardawi, M. S., & Rouzi, A. A. (2005). Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome. Fertility and Sterility, 83(6), pp. 1708-16.
    Ardawi MS, Rouzi AA. Plasma Adiponectin and Insulin Resistance in Women With Polycystic Ovary Syndrome. Fertil Steril. 2005;83(6):1708-16. PubMed PMID: 15950640.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome. AU - Ardawi,Mohammed Salleh M, AU - Rouzi,Abdulrahim A, PY - 2004/04/07/received PY - 2004/11/24/revised PY - 2004/11/24/accepted PY - 2005/6/14/pubmed PY - 2006/1/4/medline PY - 2005/6/14/entrez SP - 1708 EP - 16 JF - Fertility and sterility JO - Fertil. Steril. VL - 83 IS - 6 N2 - OBJECTIVE: To determine plasma adiponectin concentration in women with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adiponectin to the hormonal and metabolic parameters, including measures of insulin resistance (IR). DESIGN: Case-control study. SETTING: Tertiary-referral university hospital. PATIENT(S): One hundred eighty selected women were classified as follows: 45 obese (body mass index [BMI] >30 kg/m2) with PCOS; 45 lean (BMI <25 kg/m2) with PCOS; 45 obese (BMI >30 kg/m2) without PCOS, and 45 lean (BMI <25 kg/m2) without PCOS. INTERVENTION(S): Blood samples were collected from all women with or without PCOS between 8 and 11 am, after an overnight fast. MAIN OUTCOME MEASURE(S): Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), free T4, testosterone (T), 17-alpha-hydroxyprogesterone, Delta4-androstenedione (Delta4-A), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), insulin, and plasma levels of adiponectin and glucose. Measures of IR included fasting serum insulin, glucose-to-insulin ratio, and homeostasis model assessment (HOMA). RESULT(S): Adiponectin concentrations were found to be significantly decreased in women with PCOS and in obese women without PCOS as compared with lean women without PCOS. Adiponectin concentrations correlated inversely with body weight, BMI, fasting plasma glucose, serum insulin, Delta4-A, DHEA, DHEAS, and HOMA but correlated positively with serum T, SHBG, FAI, and glucose-to-insulin ratio. Multiple regression analysis showed that BMI, HOMA, Delta4-A, and insulin were independent determinants of adiponectin concentrations. CONCLUSION(S): Hypoadiponectinemia is evident in obese and lean women with PCOS with variable degree of IR; and it is suggested that IR per se or other metabolic abnormalities of PCOS are involved in the regulation of adiponectin concentration in women with PCOS. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/15950640/Plasma_adiponectin_and_insulin_resistance_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(05)00385-7 DB - PRIME DP - Unbound Medicine ER -