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Effects of growth hormone secretagogues on the release of adenohypophyseal hormones in young and old healthy dogs.
Vet J. 2006 Nov; 172(3):515-25.VJ

Abstract

The effects of three growth hormone secretagogues (GHSs), ghrelin, growth hormone-releasing peptide-6 (GHRP-6), and growth hormone-releasing hormone (GHRH), on the release of adenohypophyseal hormones, growth hormone (GH), adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), luteinising hormone (LH), prolactin (PRL) and on cortisol were investigated in young and old healthy Beagle dogs. Ghrelin proved to be the most potent GHS in young dogs, whereas in old dogs GHRH administration was associated with the highest plasma GH concentrations. The mean plasma GH response after administration of ghrelin was significantly lower in the old dogs compared with the young dogs. The mean plasma GH concentration after GHRH and GHRP-6 administration was lower in the old dogs compared with the young dogs, but this difference did not reach statistical significance. In both age groups, the GHSs were specific for GH release as they did not cause significant elevations in the plasma concentrations of ACTH, cortisol, TSH, LH, and PRL. It is concluded that in young dogs, ghrelin is a more powerful stimulator of GH release than either GHRH or GHRP-6. Ageing is associated with a decrease in GH-releasing capacity of ghrelin, whereas this decline is considerably lower for GHRH or GHRP-6.

Authors+Show Affiliations

Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium. Sofie.Bhatti@UGent.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15951209

Citation

Bhatti, Sofie F M., et al. "Effects of Growth Hormone Secretagogues On the Release of Adenohypophyseal Hormones in Young and Old Healthy Dogs." Veterinary Journal (London, England : 1997), vol. 172, no. 3, 2006, pp. 515-25.
Bhatti SF, Duchateau L, Van Ham LM, et al. Effects of growth hormone secretagogues on the release of adenohypophyseal hormones in young and old healthy dogs. Vet J. 2006;172(3):515-25.
Bhatti, S. F., Duchateau, L., Van Ham, L. M., De Vliegher, S. P., Mol, J. A., Rijnberk, A., & Kooistra, H. S. (2006). Effects of growth hormone secretagogues on the release of adenohypophyseal hormones in young and old healthy dogs. Veterinary Journal (London, England : 1997), 172(3), 515-25.
Bhatti SF, et al. Effects of Growth Hormone Secretagogues On the Release of Adenohypophyseal Hormones in Young and Old Healthy Dogs. Vet J. 2006;172(3):515-25. PubMed PMID: 15951209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of growth hormone secretagogues on the release of adenohypophyseal hormones in young and old healthy dogs. AU - Bhatti,Sofie F M, AU - Duchateau,Luc, AU - Van Ham,Luc M L, AU - De Vliegher,Sarne P, AU - Mol,Jan A, AU - Rijnberk,Ad, AU - Kooistra,Hans S, Y1 - 2005/06/13/ PY - 2005/6/14/pubmed PY - 2007/1/24/medline PY - 2005/6/14/entrez SP - 515 EP - 25 JF - Veterinary journal (London, England : 1997) JO - Vet J VL - 172 IS - 3 N2 - The effects of three growth hormone secretagogues (GHSs), ghrelin, growth hormone-releasing peptide-6 (GHRP-6), and growth hormone-releasing hormone (GHRH), on the release of adenohypophyseal hormones, growth hormone (GH), adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), luteinising hormone (LH), prolactin (PRL) and on cortisol were investigated in young and old healthy Beagle dogs. Ghrelin proved to be the most potent GHS in young dogs, whereas in old dogs GHRH administration was associated with the highest plasma GH concentrations. The mean plasma GH response after administration of ghrelin was significantly lower in the old dogs compared with the young dogs. The mean plasma GH concentration after GHRH and GHRP-6 administration was lower in the old dogs compared with the young dogs, but this difference did not reach statistical significance. In both age groups, the GHSs were specific for GH release as they did not cause significant elevations in the plasma concentrations of ACTH, cortisol, TSH, LH, and PRL. It is concluded that in young dogs, ghrelin is a more powerful stimulator of GH release than either GHRH or GHRP-6. Ageing is associated with a decrease in GH-releasing capacity of ghrelin, whereas this decline is considerably lower for GHRH or GHRP-6. SN - 1090-0233 UR - https://www.unboundmedicine.com/medline/citation/15951209/Effects_of_growth_hormone_secretagogues_on_the_release_of_adenohypophyseal_hormones_in_young_and_old_healthy_dogs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-0233(05)00120-6 DB - PRIME DP - Unbound Medicine ER -