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Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial.

Abstract

OBJECTIVE

To evaluate the efficacy and safety of 4% dimeticone lotion for treatment of head louse infestation.

DESIGN

Randomised controlled equivalence trial.

SETTING

Community, with home visits.

PARTICIPANTS

214 young people aged 4 to 18 years and 39 adults with active head louse infestation.

INTERVENTIONS

Two applications seven days apart of either 4.0% dimeticone lotion, applied for eight hours or overnight, or 0.5% phenothrin liquid, applied for 12 hours or overnight.

OUTCOME MEASURES

Cure of infestation (no evidence of head lice after second treatment) or reinfestation after cure.

RESULTS

Cure or reinfestation after cure occurred in 89 of 127 (70%) participants treated with dimeticone and 94 of 125 (75%) treated with phenothrin (difference -5%, 95% confidence interval -16% to 6%). Per protocol analysis showed that 84 of 121 (69%) participants were cured with dimeticone and 90 of 116 (78%) were cured with phenothrin. Irritant reactions occurred significantly less with dimeticone (3/127, 2%) than with phenothrin (11/125, 9%; difference -6%, -12% to -1%). Per protocol this was 3 of 121 (3%) participants treated with dimeticone and 10 of 116 (9%) treated with phenothrin (difference -6%, -12% to -0.3%).

CONCLUSION

Dimeticone lotion cures head louse infestation. Dimeticone seems less irritant than existing treatments and has a physical action on lice that should not be affected by resistance to neurotoxic insecticides.

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  • Authors+Show Affiliations

    ,

    Insect Research and Development, Shepreth, Royston SG8 6QZ. ian@insectresearch.com <ian@insectresearch.com>

    ,

    Source

    BMJ (Clinical research ed.) 330:7505 2005 Jun 18 pg 1423

    MeSH

    Administration, Topical
    Adolescent
    Adult
    Animals
    Child
    Child, Preschool
    Dimethylpolysiloxanes
    Follow-Up Studies
    Humans
    Insecticides
    Lice Infestations
    Pediculus
    Pyrethrins
    Scalp Dermatoses
    Siloxanes
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15951310

    Citation

    TY - JOUR T1 - Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial. AU - Burgess,Ian F, AU - Brown,Christine M, AU - Lee,Peter N, Y1 - 2005/06/10/ PY - 2005/6/14/pubmed PY - 2005/7/12/medline PY - 2005/6/14/entrez SP - 1423 EP - 1423 JF - BMJ (Clinical research ed.) JO - BMJ VL - 330 IS - 7505 N2 - OBJECTIVE: To evaluate the efficacy and safety of 4% dimeticone lotion for treatment of head louse infestation. DESIGN: Randomised controlled equivalence trial. SETTING: Community, with home visits. PARTICIPANTS: 214 young people aged 4 to 18 years and 39 adults with active head louse infestation. INTERVENTIONS: Two applications seven days apart of either 4.0% dimeticone lotion, applied for eight hours or overnight, or 0.5% phenothrin liquid, applied for 12 hours or overnight. OUTCOME MEASURES: Cure of infestation (no evidence of head lice after second treatment) or reinfestation after cure. RESULTS: Cure or reinfestation after cure occurred in 89 of 127 (70%) participants treated with dimeticone and 94 of 125 (75%) treated with phenothrin (difference -5%, 95% confidence interval -16% to 6%). Per protocol analysis showed that 84 of 121 (69%) participants were cured with dimeticone and 90 of 116 (78%) were cured with phenothrin. Irritant reactions occurred significantly less with dimeticone (3/127, 2%) than with phenothrin (11/125, 9%; difference -6%, -12% to -1%). Per protocol this was 3 of 121 (3%) participants treated with dimeticone and 10 of 116 (9%) treated with phenothrin (difference -6%, -12% to -0.3%). CONCLUSION: Dimeticone lotion cures head louse infestation. Dimeticone seems less irritant than existing treatments and has a physical action on lice that should not be affected by resistance to neurotoxic insecticides. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/15951310/Treatment_of_head_louse_infestation_with_4_dimeticone_lotion:_randomised_controlled_equivalence_trial_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&amp;pmid=15951310 ER -