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Periconceptional vitamin useand leukemia risk in children with Down syndrome: a Children's Oncology Group study.
Cancer. 2005 Jul 15; 104(2):405-10.C

Abstract

BACKGROUND

Periconceptional vitamin supplementation reduces the risk of neural tube defects, and possibly may reduce the risk of certain childhood malignancies, including acute lymphoblastic leukemia (ALL). Because children with Down syndrome (DS) experience a 20-fold higher risk of leukemia than the general population, the authors evaluated whether periconceptional vitamin supplementation reduced the risk of leukemia in children with DS.

METHODS

From 1997 to 2002, 158 children ages birth-18 years with DS and acute leukemia (n = 61 children with acute myeloid leukemia [AML] and n = 97 children with ALL) were enrolled through the Children's Oncology Group in North America. Children with DS alone (n = 173) were identified through the cases' pediatric clinics and frequency matched to cases on age. Mothers of cases and controls completed a telephone interview that included questions regarding vitamin supplement use in the periconceptional period and after knowledge of pregnancy.

RESULTS

A decreased risk of leukemia was observed with vitamin supplementation in the periconceptional period (odds ratio [OR] = 0.63; 95% confidence interval [95% CI], 0.39-1.00). When stratified by leukemia type, the reduced risk was observed for ALL (OR = 0.51; 95% CI, 0.30-0.89), but not for AML (OR = 0.92; 95% CI, 0.48-1.76). Compared with vitamin use in the periconceptional period, use only after knowledge of pregnancy was associated with an increased risk of leukemia (OR = 1.61; 95% CI, 1.00-2.58). This was observed for both ALL and AML.

CONCLUSIONS

These data added to a growing body of evidence that suggests that periconceptional vitamin use may be protective in the development of certain childhood cancers.

Authors+Show Affiliations

Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA. ross@epi.umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15952191

Citation

Ross, Julie A., et al. "Periconceptional Vitamin Useand Leukemia Risk in Children With Down Syndrome: a Children's Oncology Group Study." Cancer, vol. 104, no. 2, 2005, pp. 405-10.
Ross JA, Blair CK, Olshan AF, et al. Periconceptional vitamin useand leukemia risk in children with Down syndrome: a Children's Oncology Group study. Cancer. 2005;104(2):405-10.
Ross, J. A., Blair, C. K., Olshan, A. F., Robison, L. L., Smith, F. O., Heerema, N. A., & Roesler, M. (2005). Periconceptional vitamin useand leukemia risk in children with Down syndrome: a Children's Oncology Group study. Cancer, 104(2), 405-10.
Ross JA, et al. Periconceptional Vitamin Useand Leukemia Risk in Children With Down Syndrome: a Children's Oncology Group Study. Cancer. 2005 Jul 15;104(2):405-10. PubMed PMID: 15952191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periconceptional vitamin useand leukemia risk in children with Down syndrome: a Children's Oncology Group study. AU - Ross,Julie A, AU - Blair,Cindy K, AU - Olshan,Andrew F, AU - Robison,Leslie L, AU - Smith,Franklin O, AU - Heerema,Nyla A, AU - Roesler,Michelle, PY - 2005/6/14/pubmed PY - 2005/9/24/medline PY - 2005/6/14/entrez SP - 405 EP - 10 JF - Cancer JO - Cancer VL - 104 IS - 2 N2 - BACKGROUND: Periconceptional vitamin supplementation reduces the risk of neural tube defects, and possibly may reduce the risk of certain childhood malignancies, including acute lymphoblastic leukemia (ALL). Because children with Down syndrome (DS) experience a 20-fold higher risk of leukemia than the general population, the authors evaluated whether periconceptional vitamin supplementation reduced the risk of leukemia in children with DS. METHODS: From 1997 to 2002, 158 children ages birth-18 years with DS and acute leukemia (n = 61 children with acute myeloid leukemia [AML] and n = 97 children with ALL) were enrolled through the Children's Oncology Group in North America. Children with DS alone (n = 173) were identified through the cases' pediatric clinics and frequency matched to cases on age. Mothers of cases and controls completed a telephone interview that included questions regarding vitamin supplement use in the periconceptional period and after knowledge of pregnancy. RESULTS: A decreased risk of leukemia was observed with vitamin supplementation in the periconceptional period (odds ratio [OR] = 0.63; 95% confidence interval [95% CI], 0.39-1.00). When stratified by leukemia type, the reduced risk was observed for ALL (OR = 0.51; 95% CI, 0.30-0.89), but not for AML (OR = 0.92; 95% CI, 0.48-1.76). Compared with vitamin use in the periconceptional period, use only after knowledge of pregnancy was associated with an increased risk of leukemia (OR = 1.61; 95% CI, 1.00-2.58). This was observed for both ALL and AML. CONCLUSIONS: These data added to a growing body of evidence that suggests that periconceptional vitamin use may be protective in the development of certain childhood cancers. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/15952191/Periconceptional_vitamin_useand_leukemia_risk_in_children_with_Down_syndrome:_a_Children's_Oncology_Group_study_ L2 - https://doi.org/10.1002/cncr.21171 DB - PRIME DP - Unbound Medicine ER -