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Electrical measurement of moisturizing effect on skin hydration and barrier function in psoriasis patients.
Clin Exp Dermatol. 2005 Jul; 30(4):409-13.CE

Abstract

Transepidermal water loss (TEWL) in psoriatic skin lesions seems to be related to the severity of the psoriasis, and the electrical capacitance and conductance of the skin are indicators of the hydration level of the stratum corneum. We compared the characteristics of these electrical measurements, in assessing the persistent effect of a moisturizing cream on skin hydration and barrier function in psoriasis patients. Seventeen Korean psoriasis patients were recruited. Their right leg was treated with the moisturizer twice daily for 6 weeks, while their left leg was used as the control site. For each patient, one psoriatic plaque on each leg was selected as the involved psoriatic lesion. Uninvolved psoriatic skin was regarded as the apparently healthy looking skin 4-5 cm away from the periphery of the psoriatic lesion. The TEWL, electrical capacitance and conductance were measured, in order to evaluate the barrier function and hydration level of the stratum corneum. The clinical and biophysical data for each patient were recorded at the start of the study and after 2, 4 and 6 weeks. The degree of skin dryness at the applied area improved progressively. The electrical capacitance at the treated psoriatic lesion increased significantly after 2 weeks, and this improvement was maintained during the entire study period. However, no noticeable change was observed in the electrical conductance. The TEWL showed an inverse pattern to that of the skin capacitance, decreasing during the study period. The skin capacitance and TEWL exhibited good correlation with the visual assessment of skin dryness, but the skin conductance did not. Our data suggest that electrical capacitance and TEWL may be useful in the evaluation of the effect of a moisturizer on the hydration status and barrier function of psoriatic skin.

Authors+Show Affiliations

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15953083

Citation

Rim, J H., et al. "Electrical Measurement of Moisturizing Effect On Skin Hydration and Barrier Function in Psoriasis Patients." Clinical and Experimental Dermatology, vol. 30, no. 4, 2005, pp. 409-13.
Rim JH, Jo SJ, Park JY, et al. Electrical measurement of moisturizing effect on skin hydration and barrier function in psoriasis patients. Clin Exp Dermatol. 2005;30(4):409-13.
Rim, J. H., Jo, S. J., Park, J. Y., Park, B. D., & Youn, J. I. (2005). Electrical measurement of moisturizing effect on skin hydration and barrier function in psoriasis patients. Clinical and Experimental Dermatology, 30(4), 409-13.
Rim JH, et al. Electrical Measurement of Moisturizing Effect On Skin Hydration and Barrier Function in Psoriasis Patients. Clin Exp Dermatol. 2005;30(4):409-13. PubMed PMID: 15953083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrical measurement of moisturizing effect on skin hydration and barrier function in psoriasis patients. AU - Rim,J H, AU - Jo,S J, AU - Park,J Y, AU - Park,B D, AU - Youn,J I, PY - 2005/6/15/pubmed PY - 2005/9/1/medline PY - 2005/6/15/entrez SP - 409 EP - 13 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 30 IS - 4 N2 - Transepidermal water loss (TEWL) in psoriatic skin lesions seems to be related to the severity of the psoriasis, and the electrical capacitance and conductance of the skin are indicators of the hydration level of the stratum corneum. We compared the characteristics of these electrical measurements, in assessing the persistent effect of a moisturizing cream on skin hydration and barrier function in psoriasis patients. Seventeen Korean psoriasis patients were recruited. Their right leg was treated with the moisturizer twice daily for 6 weeks, while their left leg was used as the control site. For each patient, one psoriatic plaque on each leg was selected as the involved psoriatic lesion. Uninvolved psoriatic skin was regarded as the apparently healthy looking skin 4-5 cm away from the periphery of the psoriatic lesion. The TEWL, electrical capacitance and conductance were measured, in order to evaluate the barrier function and hydration level of the stratum corneum. The clinical and biophysical data for each patient were recorded at the start of the study and after 2, 4 and 6 weeks. The degree of skin dryness at the applied area improved progressively. The electrical capacitance at the treated psoriatic lesion increased significantly after 2 weeks, and this improvement was maintained during the entire study period. However, no noticeable change was observed in the electrical conductance. The TEWL showed an inverse pattern to that of the skin capacitance, decreasing during the study period. The skin capacitance and TEWL exhibited good correlation with the visual assessment of skin dryness, but the skin conductance did not. Our data suggest that electrical capacitance and TEWL may be useful in the evaluation of the effect of a moisturizer on the hydration status and barrier function of psoriatic skin. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/15953083/Electrical_measurement_of_moisturizing_effect_on_skin_hydration_and_barrier_function_in_psoriasis_patients_ L2 - https://doi.org/10.1111/j.1365-2230.2005.01773.x DB - PRIME DP - Unbound Medicine ER -