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Pulse pressure is independently associated with sensorimotor peripheral neuropathy in patients with type 2 diabetes.
J Intern Med. 2005 Jul; 258(1):38-44.JI

Abstract

OBJECTIVES

The mechanisms responsible for the onset and progression of sensorimotor peripheral neuropathy (SMPN) in type 2 diabetes remain largely unknown. Although a link between hypertension and SMPN has been observed, it is not clear which blood pressure (BP) component (i.e. systolic, SBP; diastolic, DBP; or pulse pressure, PP) is primarily involved. We sought to determine the relationship between BP components and parameters of nerve function in type 2 diabetes.

DESIGN

Cross-sectional study.

SETTING

Academic medical centre.

SUBJECTS

A total of 55 consecutive ambulatory patients with type 2 diabetes (age 62.6 +/-8.0 years, mean +/- SD).

INTERVENTIONS

Measurement of clinic BP and 10 neurophysiological parameters: motor nerve conduction velocity (NCV; median, ulnar, posterior tibial and peroneal nerve), sensory amplitude (AMP) and latency (LAT; median, ulnar and sural nerve).

RESULTS

Univariate analysis showed that age, diabetes duration, SBP and PP were negatively correlated with nerve function. Regression analysis showed that, after correcting for age, duration of diabetes, glycated haemoglobin, body mass index, microalbuminuria and SBP, PP was independently and negatively associated with NCV (median, P =0.011; ulnar, P = 0.001; peroneal, P = 0.006 and posterior tibial, P = 0.005) and signal AMP (ulnar, P = 0.027; sural, P = 0.055), and positively associated with signal LAT (median, P = 0.083; sural, P = 0.021). SBP was negatively associated with signal AMP (median, P = 0.012) and positively associated with LAT (ulnar, P = 0.018). By contrast, DBP failed to show any significant correlation with nerve function.

CONCLUSIONS

The PP is strongly associated with neurophysiological parameters of nerve function in patients with type 2 diabetes. This relationship is independent of traditional risk factors and other BP components.

Authors+Show Affiliations

Jarmuzewska EA
Department of Internal Medicine, Policlinico IRCCS, Ospedale Maggiore, University of Milan, Milan, Italy.
Mangoni AA
No affiliation info available

MeSH

Age FactorsAnalysis of VarianceAutonomic Nervous System DiseasesBlood PressureCross-Sectional StudiesDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleHumansMaleMiddle AgedNeural ConductionPeripheral Nervous System DiseasesPeroneal NerveSural NerveTibial NerveUlnar Nerve

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15953131

Citation

Jarmuzewska, E A., and A A. Mangoni. "Pulse Pressure Is Independently Associated With Sensorimotor Peripheral Neuropathy in Patients With Type 2 Diabetes." Journal of Internal Medicine, vol. 258, no. 1, 2005, pp. 38-44.
Jarmuzewska EA, Mangoni AA. Pulse pressure is independently associated with sensorimotor peripheral neuropathy in patients with type 2 diabetes. J Intern Med. 2005;258(1):38-44.
Jarmuzewska, E. A., & Mangoni, A. A. (2005). Pulse pressure is independently associated with sensorimotor peripheral neuropathy in patients with type 2 diabetes. Journal of Internal Medicine, 258(1), 38-44.
Jarmuzewska EA, Mangoni AA. Pulse Pressure Is Independently Associated With Sensorimotor Peripheral Neuropathy in Patients With Type 2 Diabetes. J Intern Med. 2005;258(1):38-44. PubMed PMID: 15953131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulse pressure is independently associated with sensorimotor peripheral neuropathy in patients with type 2 diabetes. AU - Jarmuzewska,E A, AU - Mangoni,A A, PY - 2005/6/15/pubmed PY - 2005/7/20/medline PY - 2005/6/15/entrez SP - 38 EP - 44 JF - Journal of internal medicine JO - J Intern Med VL - 258 IS - 1 N2 - OBJECTIVES: The mechanisms responsible for the onset and progression of sensorimotor peripheral neuropathy (SMPN) in type 2 diabetes remain largely unknown. Although a link between hypertension and SMPN has been observed, it is not clear which blood pressure (BP) component (i.e. systolic, SBP; diastolic, DBP; or pulse pressure, PP) is primarily involved. We sought to determine the relationship between BP components and parameters of nerve function in type 2 diabetes. DESIGN: Cross-sectional study. SETTING: Academic medical centre. SUBJECTS: A total of 55 consecutive ambulatory patients with type 2 diabetes (age 62.6 +/-8.0 years, mean +/- SD). INTERVENTIONS: Measurement of clinic BP and 10 neurophysiological parameters: motor nerve conduction velocity (NCV; median, ulnar, posterior tibial and peroneal nerve), sensory amplitude (AMP) and latency (LAT; median, ulnar and sural nerve). RESULTS: Univariate analysis showed that age, diabetes duration, SBP and PP were negatively correlated with nerve function. Regression analysis showed that, after correcting for age, duration of diabetes, glycated haemoglobin, body mass index, microalbuminuria and SBP, PP was independently and negatively associated with NCV (median, P =0.011; ulnar, P = 0.001; peroneal, P = 0.006 and posterior tibial, P = 0.005) and signal AMP (ulnar, P = 0.027; sural, P = 0.055), and positively associated with signal LAT (median, P = 0.083; sural, P = 0.021). SBP was negatively associated with signal AMP (median, P = 0.012) and positively associated with LAT (ulnar, P = 0.018). By contrast, DBP failed to show any significant correlation with nerve function. CONCLUSIONS: The PP is strongly associated with neurophysiological parameters of nerve function in patients with type 2 diabetes. This relationship is independent of traditional risk factors and other BP components. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/15953131/Pulse_pressure_is_independently_associated_with_sensorimotor_peripheral_neuropathy_in_patients_with_type_2_diabetes_ DB - PRIME DP - Unbound Medicine ER -