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Disability pattern in chronic migraine with medication overuse: a comparison with migraine without aura.
Headache. 2005 May; 45(5):553-60.H

Abstract

OBJECTIVES

To assess headache-related disability in chronic migraine with medication overuse (CMO), as defined by Silberstein and Lipton (1996, 2001) in comparison to that caused by migraine without aura, investigating similarities and differences in disability patterns in these two conditions.

BACKGROUND

It is well known that migraine has a marked impact on daily activities. Less information is available on the functional consequences of chronic migraine.

METHODS

This was a prospective study on 247 patients with CMO and 264 with migraine without aura. All completed the validated Italian version of the Migraine Disability Assessment questionnaire (MIDAS). The MIDAS total score and scores of each question (investigating total or partial inability to perform different daily activities) were evaluated, and compared in the two groups using the Mann-Whitney rank sum test. We also evaluated the number of missed days (question 1) and days with significantly reduced effectiveness at work (question 2) and in nonwork activities (questions 3, 4, and 5), using descriptive statistics.

RESULTS

MIDAS total score in the CMO group was rather high (mean 84.1, median 70) and significantly higher than in the migraine group (mean 23.4, median 19). CMO patients also reported higher scores than migraine patients in MIDAS questions investigating disability in different domains, the differences being highly significant for questions 3, 4, and 5. In both CMO and migraine the number of days with total or significant disability in nonwork activities was higher than the number of days with total or significant disability in work activities, and days spent at work with significantly reduced effectiveness were more than work days missed.

CONCLUSIONS

Our findings show that CMO has a profound effect on patients' daily functioning. They suggest that differences between CMO and migraine are mainly quantitative, while the two groups are similar in terms of disability pattern. These results are consistent with the fact that CMO may be an evolution of episodic migraine, characterized by increase in headache frequency and more evident disability in performing different daily duties.

Authors+Show Affiliations

National Neurological Institute C. Besta, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15953274

Citation

D'Amico, Domenico, et al. "Disability Pattern in Chronic Migraine With Medication Overuse: a Comparison With Migraine Without Aura." Headache, vol. 45, no. 5, 2005, pp. 553-60.
D'Amico D, Grazzi L, Usai S, et al. Disability pattern in chronic migraine with medication overuse: a comparison with migraine without aura. Headache. 2005;45(5):553-60.
D'Amico, D., Grazzi, L., Usai, S., Rigamonti, A., Curone, M., & Bussone, G. (2005). Disability pattern in chronic migraine with medication overuse: a comparison with migraine without aura. Headache, 45(5), 553-60.
D'Amico D, et al. Disability Pattern in Chronic Migraine With Medication Overuse: a Comparison With Migraine Without Aura. Headache. 2005;45(5):553-60. PubMed PMID: 15953274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disability pattern in chronic migraine with medication overuse: a comparison with migraine without aura. AU - D'Amico,Domenico, AU - Grazzi,Licia, AU - Usai,Susanna, AU - Rigamonti,Andrea, AU - Curone,Marcella, AU - Bussone,Gennaro, PY - 2005/6/15/pubmed PY - 2005/9/27/medline PY - 2005/6/15/entrez SP - 553 EP - 60 JF - Headache JO - Headache VL - 45 IS - 5 N2 - OBJECTIVES: To assess headache-related disability in chronic migraine with medication overuse (CMO), as defined by Silberstein and Lipton (1996, 2001) in comparison to that caused by migraine without aura, investigating similarities and differences in disability patterns in these two conditions. BACKGROUND: It is well known that migraine has a marked impact on daily activities. Less information is available on the functional consequences of chronic migraine. METHODS: This was a prospective study on 247 patients with CMO and 264 with migraine without aura. All completed the validated Italian version of the Migraine Disability Assessment questionnaire (MIDAS). The MIDAS total score and scores of each question (investigating total or partial inability to perform different daily activities) were evaluated, and compared in the two groups using the Mann-Whitney rank sum test. We also evaluated the number of missed days (question 1) and days with significantly reduced effectiveness at work (question 2) and in nonwork activities (questions 3, 4, and 5), using descriptive statistics. RESULTS: MIDAS total score in the CMO group was rather high (mean 84.1, median 70) and significantly higher than in the migraine group (mean 23.4, median 19). CMO patients also reported higher scores than migraine patients in MIDAS questions investigating disability in different domains, the differences being highly significant for questions 3, 4, and 5. In both CMO and migraine the number of days with total or significant disability in nonwork activities was higher than the number of days with total or significant disability in work activities, and days spent at work with significantly reduced effectiveness were more than work days missed. CONCLUSIONS: Our findings show that CMO has a profound effect on patients' daily functioning. They suggest that differences between CMO and migraine are mainly quantitative, while the two groups are similar in terms of disability pattern. These results are consistent with the fact that CMO may be an evolution of episodic migraine, characterized by increase in headache frequency and more evident disability in performing different daily duties. SN - 0017-8748 UR - https://www.unboundmedicine.com/medline/citation/15953274/Disability_pattern_in_chronic_migraine_with_medication_overuse:_a_comparison_with_migraine_without_aura_ L2 - https://doi.org/10.1111/j.1526-4610.2005.05109.x DB - PRIME DP - Unbound Medicine ER -