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Predictive factors for progressive optic nerve damage in various types of chronic open-angle glaucoma.

Abstract

PURPOSE

To evaluate whether various types of chronic open-angle glaucoma differ in predictive factors for progression of glaucomatous optic nerve damage.

DESIGN

Observational cohort study.

METHODS

SETTING

Prospective observational clinical study.

PATIENTS

517 eyes of 300 Caucasian patients with chronic open-angle glaucoma with elevated intraocular pressure (primary open-angle glaucoma, n = 289; secondary open-angle glaucoma, n = 50) and with normal intraocular pressure (n = 178).

OBSERVATION PROCEDURE

During follow-up (median: 49 months, 6 months-130 months), all patients underwent repeated evaluation of color stereo optic disk photographs and white-on-white visual field examination.

MAIN OUTCOME MEASURES

Progression of glaucoma was defined as neuroretinal rim loss during the study period.

RESULTS

For patients with elevated intraocular pressure, significantly predictive factors for eventual progression were older age, advanced perimetric damage, smaller neuroretinal rim, and larger area of beta zone of parapapillary atrophy. In contrast, in the normal intraocular pressure group, a significant predictive factor was presence of disk hemorrhages at baseline. Within the patients with elevated intraocular pressure, the primary open-angle glaucoma group and the secondary open-angle glaucoma group did not differ in predictive factors for progression of glaucoma.

CONCLUSIONS

Open-angle glaucoma patients with normal intraocular pressure and open-angle glaucoma patients with elevated intraocular pressure differ in predictive factors for eventual progression of glaucomatous optic nerve damage. It may have clinical importance and may be helpful in the discussion of the pathogenesis of the glaucomas.

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  • Authors+Show Affiliations

    ,

    Department of Medical Informatics, Biometry, and Epidemiology, Charité University Medicine Berlin, Berlin, Germany. maertus@medizin.fu-berlin.de

    , , , ,

    Source

    American journal of ophthalmology 139:6 2005 Jun pg 999-1009

    MeSH

    Adolescent
    Adult
    Aged
    Chronic Disease
    Cohort Studies
    Disease Progression
    Female
    Follow-Up Studies
    Glaucoma, Open-Angle
    Humans
    Intraocular Pressure
    Male
    Middle Aged
    Optic Disk
    Optic Nerve Diseases
    Prospective Studies
    Risk Factors
    Visual Acuity
    Visual Fields

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15953429

    Citation

    Martus, Peter, et al. "Predictive Factors for Progressive Optic Nerve Damage in Various Types of Chronic Open-angle Glaucoma." American Journal of Ophthalmology, vol. 139, no. 6, 2005, pp. 999-1009.
    Martus P, Stroux A, Budde WM, et al. Predictive factors for progressive optic nerve damage in various types of chronic open-angle glaucoma. Am J Ophthalmol. 2005;139(6):999-1009.
    Martus, P., Stroux, A., Budde, W. M., Mardin, C. Y., Korth, M., & Jonas, J. B. (2005). Predictive factors for progressive optic nerve damage in various types of chronic open-angle glaucoma. American Journal of Ophthalmology, 139(6), pp. 999-1009.
    Martus P, et al. Predictive Factors for Progressive Optic Nerve Damage in Various Types of Chronic Open-angle Glaucoma. Am J Ophthalmol. 2005;139(6):999-1009. PubMed PMID: 15953429.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Predictive factors for progressive optic nerve damage in various types of chronic open-angle glaucoma. AU - Martus,Peter, AU - Stroux,Andrea, AU - Budde,Wido M, AU - Mardin,Christian Y, AU - Korth,Matthias, AU - Jonas,Jost B, PY - 2004/07/30/received PY - 2004/12/20/accepted PY - 2005/6/15/pubmed PY - 2005/7/29/medline PY - 2005/6/15/entrez SP - 999 EP - 1009 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 139 IS - 6 N2 - PURPOSE: To evaluate whether various types of chronic open-angle glaucoma differ in predictive factors for progression of glaucomatous optic nerve damage. DESIGN: Observational cohort study. METHODS: SETTING: Prospective observational clinical study. PATIENTS: 517 eyes of 300 Caucasian patients with chronic open-angle glaucoma with elevated intraocular pressure (primary open-angle glaucoma, n = 289; secondary open-angle glaucoma, n = 50) and with normal intraocular pressure (n = 178). OBSERVATION PROCEDURE: During follow-up (median: 49 months, 6 months-130 months), all patients underwent repeated evaluation of color stereo optic disk photographs and white-on-white visual field examination. MAIN OUTCOME MEASURES: Progression of glaucoma was defined as neuroretinal rim loss during the study period. RESULTS: For patients with elevated intraocular pressure, significantly predictive factors for eventual progression were older age, advanced perimetric damage, smaller neuroretinal rim, and larger area of beta zone of parapapillary atrophy. In contrast, in the normal intraocular pressure group, a significant predictive factor was presence of disk hemorrhages at baseline. Within the patients with elevated intraocular pressure, the primary open-angle glaucoma group and the secondary open-angle glaucoma group did not differ in predictive factors for progression of glaucoma. CONCLUSIONS: Open-angle glaucoma patients with normal intraocular pressure and open-angle glaucoma patients with elevated intraocular pressure differ in predictive factors for eventual progression of glaucomatous optic nerve damage. It may have clinical importance and may be helpful in the discussion of the pathogenesis of the glaucomas. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/15953429/Predictive_factors_for_progressive_optic_nerve_damage_in_various_types_of_chronic_open_angle_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(04)01599-5 DB - PRIME DP - Unbound Medicine ER -