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Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy.
J Infect. 2006 Mar; 52(3):207-15.JI

Abstract

OBJECTIVES

This study described the clinical features, factors affecting the outcome of this disease, risk factors, and efficacy of ribavirin therapy for CCHF patients in Eastern Turkey.

METHODS

Between 2002 and 2004, 60 cases admitted to our hospital were included in this study. The diagnosis was confirmed through detection of IgM by ELISA and/or genomic segment of virus by RT-PCR.

RESULTS

In multivariate analysis, farming (OR, 11.4), living in a rural area (OR, 10.05) and being bitten by tick (OR, 6.75) were determined as risk factors for CCHF. The rates of fever during hospitalization, confusion, neck stiffness, bleeding from multiple sites, and presence of petechia/ecchymosis were higher in the patients who died than in surviving ones. Additionally, the mean values of ALT, AST, LHD, CK, PTT, INR and urea were also higher, and the mean PLT count was lower in the patients who died. Mean recovery time was shorter in the cases treated with ribavirin than those of control. But, the need for blood and blood product, mean hospitalization duration, fatality rates, and hospital expenditure values were not significantly different between the group of patients treated with ribavirin and control groups.

CONCLUSIONS

In Eastern Turkey, clinical features, factors influencing outcome of the disease, and risk factors were similar to other outbreaks of CCHF. Further studies are needed for the evaluation of ribavirin therapy in CCHF.

Authors+Show Affiliations

Department of Clinical Microbiology and Infectious Diseases, School of Medicine, Ataturk University, 25240 Erzurum, Turkey. zozkurt@atauni.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15953646

Citation

Ozkurt, Zulal, et al. "Crimean-Congo Hemorrhagic Fever in Eastern Turkey: Clinical Features, Risk Factors and Efficacy of Ribavirin Therapy." The Journal of Infection, vol. 52, no. 3, 2006, pp. 207-15.
Ozkurt Z, Kiki I, Erol S, et al. Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. J Infect. 2006;52(3):207-15.
Ozkurt, Z., Kiki, I., Erol, S., Erdem, F., Yilmaz, N., Parlak, M., Gundogdu, M., & Tasyaran, M. A. (2006). Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. The Journal of Infection, 52(3), 207-15.
Ozkurt Z, et al. Crimean-Congo Hemorrhagic Fever in Eastern Turkey: Clinical Features, Risk Factors and Efficacy of Ribavirin Therapy. J Infect. 2006;52(3):207-15. PubMed PMID: 15953646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. AU - Ozkurt,Zulal, AU - Kiki,Ilhami, AU - Erol,Serpil, AU - Erdem,Fuat, AU - Yilmaz,Neziha, AU - Parlak,Mehmet, AU - Gundogdu,Mehmet, AU - Tasyaran,Mehmet A, Y1 - 2005/06/13/ PY - 2005/03/01/received PY - 2005/05/03/accepted PY - 2005/6/15/pubmed PY - 2006/12/14/medline PY - 2005/6/15/entrez SP - 207 EP - 15 JF - The Journal of infection JO - J. Infect. VL - 52 IS - 3 N2 - OBJECTIVES: This study described the clinical features, factors affecting the outcome of this disease, risk factors, and efficacy of ribavirin therapy for CCHF patients in Eastern Turkey. METHODS: Between 2002 and 2004, 60 cases admitted to our hospital were included in this study. The diagnosis was confirmed through detection of IgM by ELISA and/or genomic segment of virus by RT-PCR. RESULTS: In multivariate analysis, farming (OR, 11.4), living in a rural area (OR, 10.05) and being bitten by tick (OR, 6.75) were determined as risk factors for CCHF. The rates of fever during hospitalization, confusion, neck stiffness, bleeding from multiple sites, and presence of petechia/ecchymosis were higher in the patients who died than in surviving ones. Additionally, the mean values of ALT, AST, LHD, CK, PTT, INR and urea were also higher, and the mean PLT count was lower in the patients who died. Mean recovery time was shorter in the cases treated with ribavirin than those of control. But, the need for blood and blood product, mean hospitalization duration, fatality rates, and hospital expenditure values were not significantly different between the group of patients treated with ribavirin and control groups. CONCLUSIONS: In Eastern Turkey, clinical features, factors influencing outcome of the disease, and risk factors were similar to other outbreaks of CCHF. Further studies are needed for the evaluation of ribavirin therapy in CCHF. SN - 1532-2742 UR - https://www.unboundmedicine.com/medline/citation/15953646/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(05)00130-1 DB - PRIME DP - Unbound Medicine ER -