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Depression, the autonomic nervous system, and coronary heart disease.
Psychosom Med. 2005 May-Jun; 67 Suppl 1:S29-33.PM

Abstract

Depression is a risk factor for medical morbidity and mortality in patients with coronary heart disease (CHD). Dysregulation of the autonomic nervous system (ANS) may explain why depressed patients are at increased risk. Studies of medically well, depressed psychiatric patients have found elevated levels of plasma catecholamines and other markers of altered ANS function compared with controls. Studies of depressed patients with CHD have also uncovered evidence of ANS dysfunction, including elevated heart rate, low heart rate variability, exaggerated heart rate responses to physical stressors, high variability in ventricular repolarization, and low baroreceptor sensitivity. All of these indicators of ANS dysfunction have been associated with increased risks of mortality and cardiac morbidity in patients with CHD. Further research is needed to determine whether ANS dysfunction mediates the effects of depression on the course and outcome of CHD, and to develop clinical interventions that improve cardiovascular autonomic regulation while relieving depression in patients with CHD.

Authors+Show Affiliations

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. carneyr@bmc.wustl.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15953797

Citation

Carney, Robert M., et al. "Depression, the Autonomic Nervous System, and Coronary Heart Disease." Psychosomatic Medicine, vol. 67 Suppl 1, 2005, pp. S29-33.
Carney RM, Freedland KE, Veith RC. Depression, the autonomic nervous system, and coronary heart disease. Psychosom Med. 2005;67 Suppl 1:S29-33.
Carney, R. M., Freedland, K. E., & Veith, R. C. (2005). Depression, the autonomic nervous system, and coronary heart disease. Psychosomatic Medicine, 67 Suppl 1, S29-33.
Carney RM, Freedland KE, Veith RC. Depression, the Autonomic Nervous System, and Coronary Heart Disease. Psychosom Med. 2005 May-Jun;67 Suppl 1:S29-33. PubMed PMID: 15953797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression, the autonomic nervous system, and coronary heart disease. AU - Carney,Robert M, AU - Freedland,Kenneth E, AU - Veith,Richard C, PY - 2005/6/15/pubmed PY - 2006/7/19/medline PY - 2005/6/15/entrez SP - S29 EP - 33 JF - Psychosomatic medicine JO - Psychosom Med VL - 67 Suppl 1 N2 - Depression is a risk factor for medical morbidity and mortality in patients with coronary heart disease (CHD). Dysregulation of the autonomic nervous system (ANS) may explain why depressed patients are at increased risk. Studies of medically well, depressed psychiatric patients have found elevated levels of plasma catecholamines and other markers of altered ANS function compared with controls. Studies of depressed patients with CHD have also uncovered evidence of ANS dysfunction, including elevated heart rate, low heart rate variability, exaggerated heart rate responses to physical stressors, high variability in ventricular repolarization, and low baroreceptor sensitivity. All of these indicators of ANS dysfunction have been associated with increased risks of mortality and cardiac morbidity in patients with CHD. Further research is needed to determine whether ANS dysfunction mediates the effects of depression on the course and outcome of CHD, and to develop clinical interventions that improve cardiovascular autonomic regulation while relieving depression in patients with CHD. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/15953797/Depression_the_autonomic_nervous_system_and_coronary_heart_disease_ L2 - https://doi.org/10.1097/01.psy.0000162254.61556.d5 DB - PRIME DP - Unbound Medicine ER -