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Glycemic index, glycemic load, and pancreatic cancer risk (Canada).
Cancer Causes Control 2005; 16(4):431-6CC

Abstract

There is some evidence that plasma insulin and postload plasma glucose may be associated with risk of pancreatic cancer. Glycemic index and glycemic load are measures, which allow the carbohydrate content of individual foods to be classified according to their postprandial glycemic effects and hence their effects on circulating insulin levels. Therefore, we examined pancreatic cancer risk in association with glycemic index (GI), glycemic load (GL), and intake of dietary carbohydrate and sugar in a prospective cohort of 49,613 Canadian women enrolled in the National Breast Screening Study (NBSS) who completed a self-administered food frequency questionnaire between 1980 and 1985. Linkages to national cancer and mortality databases yielded data on cancer incidence and deaths, with follow-up ending between 1998 and 2000. During a mean 16.5 years of follow-up, we observed 112 incident pancreatic cancer cases. There was no association between overall glycemic index, glycemic load, total carbohydrate and total sugar intake and pancreatic cancer risk. In multivariate adjusted models, the hazard ratio (HR) for the highest versus lowest quartile levels of overall GI and GL were 1.43 (95% confidence interval [CI]=0.56-3.65, P(trend)=0.58) and 0.80 (95% CI=0.45-1.41, P(trend)=0.41), respectively. Our data suggest that overall glycemic index and glycemic load, as well as total sugar and total carbohydrate intake, are not associated with pancreatic cancer risk. However, given the limited literature regarding the role of diet in the etiology of pancreatic cancer, particularly with respect to glycemic index/load, further investigation is warranted.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 1301, Bronx, NY 10461, USA. ssilvera@aecom.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15953985

Citation

Silvera, Stephanie A N., et al. "Glycemic Index, Glycemic Load, and Pancreatic Cancer Risk (Canada)." Cancer Causes & Control : CCC, vol. 16, no. 4, 2005, pp. 431-6.
Silvera SA, Rohan TE, Jain M, et al. Glycemic index, glycemic load, and pancreatic cancer risk (Canada). Cancer Causes Control. 2005;16(4):431-6.
Silvera, S. A., Rohan, T. E., Jain, M., Terry, P. D., Howe, G. R., & Miller, A. B. (2005). Glycemic index, glycemic load, and pancreatic cancer risk (Canada). Cancer Causes & Control : CCC, 16(4), pp. 431-6.
Silvera SA, et al. Glycemic Index, Glycemic Load, and Pancreatic Cancer Risk (Canada). Cancer Causes Control. 2005;16(4):431-6. PubMed PMID: 15953985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycemic index, glycemic load, and pancreatic cancer risk (Canada). AU - Silvera,Stephanie A N, AU - Rohan,Thomas E, AU - Jain,Meera, AU - Terry,Paul D, AU - Howe,Geoffrey R, AU - Miller,Anthony B, PY - 2004/08/27/received PY - 2004/10/18/accepted PY - 2005/6/15/pubmed PY - 2005/11/9/medline PY - 2005/6/15/entrez SP - 431 EP - 6 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 4 N2 - There is some evidence that plasma insulin and postload plasma glucose may be associated with risk of pancreatic cancer. Glycemic index and glycemic load are measures, which allow the carbohydrate content of individual foods to be classified according to their postprandial glycemic effects and hence their effects on circulating insulin levels. Therefore, we examined pancreatic cancer risk in association with glycemic index (GI), glycemic load (GL), and intake of dietary carbohydrate and sugar in a prospective cohort of 49,613 Canadian women enrolled in the National Breast Screening Study (NBSS) who completed a self-administered food frequency questionnaire between 1980 and 1985. Linkages to national cancer and mortality databases yielded data on cancer incidence and deaths, with follow-up ending between 1998 and 2000. During a mean 16.5 years of follow-up, we observed 112 incident pancreatic cancer cases. There was no association between overall glycemic index, glycemic load, total carbohydrate and total sugar intake and pancreatic cancer risk. In multivariate adjusted models, the hazard ratio (HR) for the highest versus lowest quartile levels of overall GI and GL were 1.43 (95% confidence interval [CI]=0.56-3.65, P(trend)=0.58) and 0.80 (95% CI=0.45-1.41, P(trend)=0.41), respectively. Our data suggest that overall glycemic index and glycemic load, as well as total sugar and total carbohydrate intake, are not associated with pancreatic cancer risk. However, given the limited literature regarding the role of diet in the etiology of pancreatic cancer, particularly with respect to glycemic index/load, further investigation is warranted. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/15953985/Glycemic_index_glycemic_load_and_pancreatic_cancer_risk__Canada__ L2 - https://doi.org/10.1007/s10552-004-5028-7 DB - PRIME DP - Unbound Medicine ER -