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Cerebral state index during anaesthetic induction: a comparative study with propofol or nitrous oxide.
Acta Anaesthesiol Scand. 2005 Jul; 49(6):750-3.AA

Abstract

BACKGROUND

Confidently predicting the depth of anaesthesia for the individual patient and independently of drug(s) type using EEG-based monitors has proven difficult. This open, randomized, explorative study of day surgical patients evaluates the ability of the Cerebral State Monitor (Danmeter AB, Odense, Denmark) of anaesthetic depth to identify loss of response (LOR) using either propofol or N(2)0 for induction.

METHODS

In this open, randomized study, day surgical patients (n=10 in each group) were studied using the Cerebral State Index Monitor. After baseline measurements, induction to LOR was achieved with either repeated 30-mg boluses of propofol every second minute or with N(2)0 (after premedication 5 min before with 30 mg propofol) increased every other minute in 15% increments (max. 75%). Sedation level was evaluated every other minute using the Observer's Assessment of Alertness/Sedation scale.

RESULTS

Baseline values were 91 (82-98) and 94 (82-100) for N(2)0 and propofol patients, respectively. During induction CSI decreased with increasing sedation in patients given propofol (P<0.001) but not in patients given nitrous oxide. Median value at LOR was 56 (40-76) and 95 (87-100) for the propofol and nitrous oxide group of patients, respectively.

CONCLUSION

The Cerebral State Index(trade mark) behaves as other depth of anaesthesia monitors with a progressive decrease during propofol induction but loss of consciousness with N(2)0 results in no change in CSI.

Authors+Show Affiliations

Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15954953

Citation

Anderson, R E., et al. "Cerebral State Index During Anaesthetic Induction: a Comparative Study With Propofol or Nitrous Oxide." Acta Anaesthesiologica Scandinavica, vol. 49, no. 6, 2005, pp. 750-3.
Anderson RE, Barr G, Jakobsson JG. Cerebral state index during anaesthetic induction: a comparative study with propofol or nitrous oxide. Acta Anaesthesiol Scand. 2005;49(6):750-3.
Anderson, R. E., Barr, G., & Jakobsson, J. G. (2005). Cerebral state index during anaesthetic induction: a comparative study with propofol or nitrous oxide. Acta Anaesthesiologica Scandinavica, 49(6), 750-3.
Anderson RE, Barr G, Jakobsson JG. Cerebral State Index During Anaesthetic Induction: a Comparative Study With Propofol or Nitrous Oxide. Acta Anaesthesiol Scand. 2005;49(6):750-3. PubMed PMID: 15954953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral state index during anaesthetic induction: a comparative study with propofol or nitrous oxide. AU - Anderson,R E, AU - Barr,G, AU - Jakobsson,J G, PY - 2005/6/16/pubmed PY - 2005/10/14/medline PY - 2005/6/16/entrez SP - 750 EP - 3 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 49 IS - 6 N2 - BACKGROUND: Confidently predicting the depth of anaesthesia for the individual patient and independently of drug(s) type using EEG-based monitors has proven difficult. This open, randomized, explorative study of day surgical patients evaluates the ability of the Cerebral State Monitor (Danmeter AB, Odense, Denmark) of anaesthetic depth to identify loss of response (LOR) using either propofol or N(2)0 for induction. METHODS: In this open, randomized study, day surgical patients (n=10 in each group) were studied using the Cerebral State Index Monitor. After baseline measurements, induction to LOR was achieved with either repeated 30-mg boluses of propofol every second minute or with N(2)0 (after premedication 5 min before with 30 mg propofol) increased every other minute in 15% increments (max. 75%). Sedation level was evaluated every other minute using the Observer's Assessment of Alertness/Sedation scale. RESULTS: Baseline values were 91 (82-98) and 94 (82-100) for N(2)0 and propofol patients, respectively. During induction CSI decreased with increasing sedation in patients given propofol (P<0.001) but not in patients given nitrous oxide. Median value at LOR was 56 (40-76) and 95 (87-100) for the propofol and nitrous oxide group of patients, respectively. CONCLUSION: The Cerebral State Index(trade mark) behaves as other depth of anaesthesia monitors with a progressive decrease during propofol induction but loss of consciousness with N(2)0 results in no change in CSI. SN - 0001-5172 UR - https://www.unboundmedicine.com/medline/citation/15954953/Cerebral_state_index_during_anaesthetic_induction:_a_comparative_study_with_propofol_or_nitrous_oxide_ L2 - https://doi.org/10.1111/j.1399-6576.2005.00737.x DB - PRIME DP - Unbound Medicine ER -