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Prevalence and risk factors associated with the metabolic syndrome and dyslipidemia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela.
Diabetes Res Clin Pract. 2005 Jul; 69(1):63-77.DR

Abstract

Studies have highlighted the association between insulin resistance (IR) and several cardiovascular (CV) risk factors, including hypertension (HTN), obesity, dyslipidemia (i.e. high triglyceride and low HDL-cholesterol) and glucose intolerance, in a cluster known as the metabolic syndrome (MS). There are few data on the frequency of the MS and dyslipidemia in developing countries, and none in South America. To estimate the prevalence of the MS and its components in Zulia State, Venezuela, and to establish associated demographic and clinical factors, we evaluated 3108 Hispanic men and women aged 20 years or older from a cross-sectional survey of a random representative sample from each health district in Zulia State, Venezuela (1999-2001). Prevalence of the MS and dyslipidemia was defined according to the National Cholesterol Education Program (NCEP)/Adult Treatment Panel III (ATP III) criteria. The age-adjusted prevalence of MS and dyslipidemia was 31.2% and 24.1%, respectively, with higher rates in men than in women. Prevalence rates increased with age and with the degree of obesity. MS prevalence was lower in Amerindian (17.%) compared to Black (27.2%), White (33.3%) and Mixed (37.4%) men, but no differences were found among women. Overall, low HDL-cholesterol (65.3%), abdominal obesity (42.9%) and HTN (38.1%) were the most frequent MS components. After adjusting for age, sex and race groups, family history of diabetes, obesity and HTN were associated with the MS. Sedentary lifestyle also increased the risk of MS, event after adjusting for the same covariates, obesity and the degree of IR. These results suggest that MS is found in approximately one-third of the Venezuelan adult population in Zulia State, with higher prevalence in men related to the presence of dyslipidemia. Lifestyle interventions in MS subjects are needed in Venezuela to halt the burden of CV disease and diabetes.

Authors+Show Affiliations

University of Miami Miller School of Medicine, 1450 NW 10th Avenue, Diabetes Research Institute #2054, Miami, FL 33136, USA. hflorez@med.miami.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15955388

Citation

Florez, Hermes, et al. "Prevalence and Risk Factors Associated With the Metabolic Syndrome and Dyslipidemia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela." Diabetes Research and Clinical Practice, vol. 69, no. 1, 2005, pp. 63-77.
Florez H, Silva E, Fernández V, et al. Prevalence and risk factors associated with the metabolic syndrome and dyslipidemia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela. Diabetes Res Clin Pract. 2005;69(1):63-77.
Florez, H., Silva, E., Fernández, V., Ryder, E., Sulbarán, T., Campos, G., Calmón, G., Clavel, E., Castillo-Florez, S., & Goldberg, R. (2005). Prevalence and risk factors associated with the metabolic syndrome and dyslipidemia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela. Diabetes Research and Clinical Practice, 69(1), 63-77.
Florez H, et al. Prevalence and Risk Factors Associated With the Metabolic Syndrome and Dyslipidemia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela. Diabetes Res Clin Pract. 2005;69(1):63-77. PubMed PMID: 15955388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and risk factors associated with the metabolic syndrome and dyslipidemia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela. AU - Florez,Hermes, AU - Silva,Eglé, AU - Fernández,Virginia, AU - Ryder,Elena, AU - Sulbarán,Tulio, AU - Campos,Gilberto, AU - Calmón,Gustavo, AU - Clavel,Emilio, AU - Castillo-Florez,Sumaya, AU - Goldberg,Ronald, Y1 - 2005/02/19/ PY - 2004/09/30/received PY - 2004/11/05/accepted PY - 2005/6/16/pubmed PY - 2005/10/27/medline PY - 2005/6/16/entrez SP - 63 EP - 77 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 69 IS - 1 N2 - Studies have highlighted the association between insulin resistance (IR) and several cardiovascular (CV) risk factors, including hypertension (HTN), obesity, dyslipidemia (i.e. high triglyceride and low HDL-cholesterol) and glucose intolerance, in a cluster known as the metabolic syndrome (MS). There are few data on the frequency of the MS and dyslipidemia in developing countries, and none in South America. To estimate the prevalence of the MS and its components in Zulia State, Venezuela, and to establish associated demographic and clinical factors, we evaluated 3108 Hispanic men and women aged 20 years or older from a cross-sectional survey of a random representative sample from each health district in Zulia State, Venezuela (1999-2001). Prevalence of the MS and dyslipidemia was defined according to the National Cholesterol Education Program (NCEP)/Adult Treatment Panel III (ATP III) criteria. The age-adjusted prevalence of MS and dyslipidemia was 31.2% and 24.1%, respectively, with higher rates in men than in women. Prevalence rates increased with age and with the degree of obesity. MS prevalence was lower in Amerindian (17.%) compared to Black (27.2%), White (33.3%) and Mixed (37.4%) men, but no differences were found among women. Overall, low HDL-cholesterol (65.3%), abdominal obesity (42.9%) and HTN (38.1%) were the most frequent MS components. After adjusting for age, sex and race groups, family history of diabetes, obesity and HTN were associated with the MS. Sedentary lifestyle also increased the risk of MS, event after adjusting for the same covariates, obesity and the degree of IR. These results suggest that MS is found in approximately one-third of the Venezuelan adult population in Zulia State, with higher prevalence in men related to the presence of dyslipidemia. Lifestyle interventions in MS subjects are needed in Venezuela to halt the burden of CV disease and diabetes. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/15955388/Prevalence_and_risk_factors_associated_with_the_metabolic_syndrome_and_dyslipidemia_in_White_Black_Amerindian_and_Mixed_Hispanics_in_Zulia_State_Venezuela_ DB - PRIME DP - Unbound Medicine ER -