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Herbal remedies in the management of diabetes: lessons learned from the study of ginseng.

Abstract

The only example of an approved antidiabetic drug that was developed from a herbal source with a long history of use for diabetes is the biguanide Metformin from French lilac (Galega officinalis). Clinical data are beginning to emerge that support antidiabetic indications for several other herbs. This viewpoint discusses the state of the evidence for their clinical antidiabetic efficacy. One of the most studied herbs, ginseng (Panax spp.), is used as a model to illustrate the challenges associated with achieving reproducible clinical efficacy. It is concluded that the best evidence for clinical efficacy in diabetes remains for ginseng. But overall insufficient evidence exists to claim a diabetes indication for herbs. The experience with ginseng suggests that although reproducible efficacy may be achieved using an acute postprandial clinical screening model to select an efficacious ginseng batch, dose, and time of administration, there is a need to develop a basis for standardization that ties the composition of herbs to efficacy. In absence of such standardization, the use of herbs in diabetes must be approached cautiously.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada. v.vuksan@utoronto.ca

    Source

    MeSH

    Complementary Therapies
    Diabetes Mellitus
    Evidence-Based Medicine
    Humans
    Hypoglycemic Agents
    Panax
    Phytotherapy
    Plant Extracts
    Plants, Medicinal
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    15955462

    Citation

    Vuksan, Vladimir, and John L. Sievenpiper. "Herbal Remedies in the Management of Diabetes: Lessons Learned From the Study of Ginseng." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 15, no. 3, 2005, pp. 149-60.
    Vuksan V, Sievenpiper JL. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutr Metab Cardiovasc Dis. 2005;15(3):149-60.
    Vuksan, V., & Sievenpiper, J. L. (2005). Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 15(3), pp. 149-60.
    Vuksan V, Sievenpiper JL. Herbal Remedies in the Management of Diabetes: Lessons Learned From the Study of Ginseng. Nutr Metab Cardiovasc Dis. 2005;15(3):149-60. PubMed PMID: 15955462.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. AU - Vuksan,Vladimir, AU - Sievenpiper,John L, PY - 2005/02/09/received PY - 2005/04/27/revised PY - 2005/05/05/accepted PY - 2005/6/16/pubmed PY - 2005/10/21/medline PY - 2005/6/16/entrez SP - 149 EP - 60 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 15 IS - 3 N2 - The only example of an approved antidiabetic drug that was developed from a herbal source with a long history of use for diabetes is the biguanide Metformin from French lilac (Galega officinalis). Clinical data are beginning to emerge that support antidiabetic indications for several other herbs. This viewpoint discusses the state of the evidence for their clinical antidiabetic efficacy. One of the most studied herbs, ginseng (Panax spp.), is used as a model to illustrate the challenges associated with achieving reproducible clinical efficacy. It is concluded that the best evidence for clinical efficacy in diabetes remains for ginseng. But overall insufficient evidence exists to claim a diabetes indication for herbs. The experience with ginseng suggests that although reproducible efficacy may be achieved using an acute postprandial clinical screening model to select an efficacious ginseng batch, dose, and time of administration, there is a need to develop a basis for standardization that ties the composition of herbs to efficacy. In absence of such standardization, the use of herbs in diabetes must be approached cautiously. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/15955462/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(05)00083-9 DB - PRIME DP - Unbound Medicine ER -