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Multiple components of lateral posterior parietal activation associated with cognitive set shifting.
Neuroimage. 2005 Jul 01; 26(3):694-702.N

Abstract

Posterior parietal activation has commonly been observed in previous neuroimaging studies in association with flexible shifting of cognitive set. However, it is not clear whether the parietal activation reflects cognitive processes intrinsic to the shifting itself or other confounding factors such as spatial attention. To address this issue, the Wisconsin Card Sorting Task (WCST) was modified such that spatial components were eliminated from the sensory and motor aspects of the task. Moreover, a visual instruction of a next dimension was introduced to eliminate cognitive processes related to trial and error identification of a next rule, and a control null-instruction was also introduced to eliminate perceptual/oddball effects of the instruction cue. Localizer scans using a visually guided saccade task were also conducted to identify eye movement/spatial attention-related areas. Activity related to set shifting with trial and error was revealed in the lateral parts of the intraparietal regions, while activity related to eye movements/spatial attention was revealed in the medial parts of the intraparietal regions, confirming little spatial contribution to the modified WCST as indexed by the double dissociation. The lateral intraparietal activity was bilateral, but when the instructed shifting was contrasted with the null-instructed shifting to purify the shift-related activity further, the left intraparietal activation was significantly greater than that in the right hemisphere. These results reveal the left hemisphere dominance of purified shifting-related activity in the lateral posterior parietal cortex that may cooperate with the lateral prefrontal cortex whose left hemisphere dominance has already been reported.

Authors+Show Affiliations

Asari T
Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.
Konishi S
No affiliation info available
Jimura K
No affiliation info available
Miyashita Y
No affiliation info available

MeSH

AdultAttentionBlinkingCognitionCuesEye MovementsFemaleFixation, OcularFunctional LateralityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeuropsychological TestsParietal LobePhotic StimulationPsychomotor PerformanceSaccadesSet, PsychologySpace Perception

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15955479

Citation

Asari, Tomoki, et al. "Multiple Components of Lateral Posterior Parietal Activation Associated With Cognitive Set Shifting." NeuroImage, vol. 26, no. 3, 2005, pp. 694-702.
Asari T, Konishi S, Jimura K, et al. Multiple components of lateral posterior parietal activation associated with cognitive set shifting. Neuroimage. 2005;26(3):694-702.
Asari, T., Konishi, S., Jimura, K., & Miyashita, Y. (2005). Multiple components of lateral posterior parietal activation associated with cognitive set shifting. NeuroImage, 26(3), 694-702.
Asari T, et al. Multiple Components of Lateral Posterior Parietal Activation Associated With Cognitive Set Shifting. Neuroimage. 2005 Jul 1;26(3):694-702. PubMed PMID: 15955479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple components of lateral posterior parietal activation associated with cognitive set shifting. AU - Asari,Tomoki, AU - Konishi,Seiki, AU - Jimura,Koji, AU - Miyashita,Yasushi, Y1 - 2005/04/01/ PY - 2004/07/06/received PY - 2004/12/13/revised PY - 2004/12/20/accepted PY - 2005/6/16/pubmed PY - 2005/8/24/medline PY - 2005/6/16/entrez SP - 694 EP - 702 JF - NeuroImage JO - Neuroimage VL - 26 IS - 3 N2 - Posterior parietal activation has commonly been observed in previous neuroimaging studies in association with flexible shifting of cognitive set. However, it is not clear whether the parietal activation reflects cognitive processes intrinsic to the shifting itself or other confounding factors such as spatial attention. To address this issue, the Wisconsin Card Sorting Task (WCST) was modified such that spatial components were eliminated from the sensory and motor aspects of the task. Moreover, a visual instruction of a next dimension was introduced to eliminate cognitive processes related to trial and error identification of a next rule, and a control null-instruction was also introduced to eliminate perceptual/oddball effects of the instruction cue. Localizer scans using a visually guided saccade task were also conducted to identify eye movement/spatial attention-related areas. Activity related to set shifting with trial and error was revealed in the lateral parts of the intraparietal regions, while activity related to eye movements/spatial attention was revealed in the medial parts of the intraparietal regions, confirming little spatial contribution to the modified WCST as indexed by the double dissociation. The lateral intraparietal activity was bilateral, but when the instructed shifting was contrasted with the null-instructed shifting to purify the shift-related activity further, the left intraparietal activation was significantly greater than that in the right hemisphere. These results reveal the left hemisphere dominance of purified shifting-related activity in the lateral posterior parietal cortex that may cooperate with the lateral prefrontal cortex whose left hemisphere dominance has already been reported. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/15955479/Multiple_components_of_lateral_posterior_parietal_activation_associated_with_cognitive_set_shifting_ DB - PRIME DP - Unbound Medicine ER -