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Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs.
Neuropsychopharmacology. 2005 Nov; 30(11):1996-2005.N

Abstract

In the present study, we investigated whether mice lacking the arginine vasopressin (AVP) V1b receptor (V1bR) exhibit deficits of prepulse inhibition (PPI) of the startle reflex, reminiscent of the sensorimotor gating deficits observed in a large majority of schizophrenic patients. V1bR knockout (KO) mice displayed significantly reduced levels of PPI of the startle reflex. In addition to PPI deficits, V1bR KO mice showed increased acoustic startle response. However, acoustic startle response was not significantly correlated to the PPI of the startle reflex in V1bR KO mice. V1bR KO mice also showed a decrease in basal levels of extracellular dopamine (DA) in the medial prefrontal cortex, which is thought to be an important brain region for PPI. Moreover, PPI deficits observed in the V1bR KO mice are significantly reversed by atypical antipsychotics such as risperidone and clozapine but not by a typical neuroleptic haloperidol, like in schizophrenic patients. By contrast, we did not observe any significant differences between V1bR KO mice and wild-type mice in the open-field, light/dark, elevated plus maze, and forced swimming tests. The results of the present study indicate that V1bR may be involved in the regulation of PPI of the startle reflex. The V1bR has been considered an important molecular target for the development of antipsychotic drugs.

Authors+Show Affiliations

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15956991

Citation

Egashira, Nobuaki, et al. "Disruption of the Prepulse Inhibition of the Startle Reflex in Vasopressin V1b Receptor Knockout Mice: Reversal By Antipsychotic Drugs." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 30, no. 11, 2005, pp. 1996-2005.
Egashira N, Tanoue A, Higashihara F, et al. Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs. Neuropsychopharmacology. 2005;30(11):1996-2005.
Egashira, N., Tanoue, A., Higashihara, F., Fuchigami, H., Sano, K., Mishima, K., Fukue, Y., Nagai, H., Takano, Y., Tsujimoto, G., Stemmelin, J., Griebel, G., Iwasaki, K., Ikeda, T., Nishimura, R., & Fujiwara, M. (2005). Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 30(11), 1996-2005.
Egashira N, et al. Disruption of the Prepulse Inhibition of the Startle Reflex in Vasopressin V1b Receptor Knockout Mice: Reversal By Antipsychotic Drugs. Neuropsychopharmacology. 2005;30(11):1996-2005. PubMed PMID: 15956991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs. AU - Egashira,Nobuaki, AU - Tanoue,Akito, AU - Higashihara,Fuminori, AU - Fuchigami,Hiroko, AU - Sano,Kazunori, AU - Mishima,Kenichi, AU - Fukue,Yoshihiko, AU - Nagai,Hiroshi, AU - Takano,Yukio, AU - Tsujimoto,Gozoh, AU - Stemmelin,Jeanne, AU - Griebel,Guy, AU - Iwasaki,Katsunori, AU - Ikeda,Tomoaki, AU - Nishimura,Ryoji, AU - Fujiwara,Michihiro, PY - 2005/6/16/pubmed PY - 2006/1/25/medline PY - 2005/6/16/entrez SP - 1996 EP - 2005 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 30 IS - 11 N2 - In the present study, we investigated whether mice lacking the arginine vasopressin (AVP) V1b receptor (V1bR) exhibit deficits of prepulse inhibition (PPI) of the startle reflex, reminiscent of the sensorimotor gating deficits observed in a large majority of schizophrenic patients. V1bR knockout (KO) mice displayed significantly reduced levels of PPI of the startle reflex. In addition to PPI deficits, V1bR KO mice showed increased acoustic startle response. However, acoustic startle response was not significantly correlated to the PPI of the startle reflex in V1bR KO mice. V1bR KO mice also showed a decrease in basal levels of extracellular dopamine (DA) in the medial prefrontal cortex, which is thought to be an important brain region for PPI. Moreover, PPI deficits observed in the V1bR KO mice are significantly reversed by atypical antipsychotics such as risperidone and clozapine but not by a typical neuroleptic haloperidol, like in schizophrenic patients. By contrast, we did not observe any significant differences between V1bR KO mice and wild-type mice in the open-field, light/dark, elevated plus maze, and forced swimming tests. The results of the present study indicate that V1bR may be involved in the regulation of PPI of the startle reflex. The V1bR has been considered an important molecular target for the development of antipsychotic drugs. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/15956991/Disruption_of_the_prepulse_inhibition_of_the_startle_reflex_in_vasopressin_V1b_receptor_knockout_mice:_reversal_by_antipsychotic_drugs_ L2 - https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=66 DB - PRIME DP - Unbound Medicine ER -