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Effects of SCH-23390 infused into the amygdala or adjacent cortex and basal ganglia on cocaine seeking and self-administration in rats.
Neuropsychopharmacology. 2006 Feb; 31(2):363-74.N

Abstract

Amygdala D1 receptors have been implicated in the motivating effects of cocaine-conditioned cues and cocaine itself, but the specific nucleus involved is unclear. Thus, we infused the D1 antagonist, SCH-23390, into the rostral basolateral amygdala (rBLA), caudal basolateral amygdala (cBLA), or central amygdala (CEA), and tested its effects on self-administration of cocaine, as well as reinstatement of extinguished cocaine-seeking behavior by cocaine-conditioned cues or cocaine itself. Two anatomical controls, the posterior regions of basal ganglia (BG) and somatosensory/insular cortices (CTX), were also examined. Cocaine self-administration was increased and cue and cocaine reinstatement were decreased by SCH-23390 infusion into every region when examined across the hour test session, with the exception that cBLA infusion did not alter cocaine reinstatement. In the first 20 min of the session, when SCH-23390 was more localized in the target sites, self-administration was increased by infusion into the CEA, cBLA, BG, and CTX, with lesser increases in the rBLA. Cocaine reinstatement was attenuated during the first 20 min only by infusion into the CEA, rBLA, and CTX. Cue reinstatement was not reliably observed in the first 20 min, but there was a trend for attenuation by infusion into the cBLA, and surprisingly, significant attenuations in the BG and CTX. The findings suggest that D1 receptors in subregions of the amygdala play differential roles in the reinforcing/motivational effects of cocaine, while the cue reinstatement effects are less clear. Further research is needed to examine the novel findings that neighboring regions of the BG and CTX may play a role in motivation for cocaine.

Authors+Show Affiliations

Department of Psychology, Arizona State University, Tempe, 85287, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

15957007

Citation

Alleweireldt, Andrea T., et al. "Effects of SCH-23390 Infused Into the Amygdala or Adjacent Cortex and Basal Ganglia On Cocaine Seeking and Self-administration in Rats." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 31, no. 2, 2006, pp. 363-74.
Alleweireldt AT, Hobbs RJ, Taylor AR, et al. Effects of SCH-23390 infused into the amygdala or adjacent cortex and basal ganglia on cocaine seeking and self-administration in rats. Neuropsychopharmacology. 2006;31(2):363-74.
Alleweireldt, A. T., Hobbs, R. J., Taylor, A. R., & Neisewander, J. L. (2006). Effects of SCH-23390 infused into the amygdala or adjacent cortex and basal ganglia on cocaine seeking and self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 31(2), 363-74.
Alleweireldt AT, et al. Effects of SCH-23390 Infused Into the Amygdala or Adjacent Cortex and Basal Ganglia On Cocaine Seeking and Self-administration in Rats. Neuropsychopharmacology. 2006;31(2):363-74. PubMed PMID: 15957007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of SCH-23390 infused into the amygdala or adjacent cortex and basal ganglia on cocaine seeking and self-administration in rats. AU - Alleweireldt,Andrea T, AU - Hobbs,Rebecca J, AU - Taylor,Adam R, AU - Neisewander,Janet L, PY - 2005/6/16/pubmed PY - 2006/7/11/medline PY - 2005/6/16/entrez SP - 363 EP - 74 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 31 IS - 2 N2 - Amygdala D1 receptors have been implicated in the motivating effects of cocaine-conditioned cues and cocaine itself, but the specific nucleus involved is unclear. Thus, we infused the D1 antagonist, SCH-23390, into the rostral basolateral amygdala (rBLA), caudal basolateral amygdala (cBLA), or central amygdala (CEA), and tested its effects on self-administration of cocaine, as well as reinstatement of extinguished cocaine-seeking behavior by cocaine-conditioned cues or cocaine itself. Two anatomical controls, the posterior regions of basal ganglia (BG) and somatosensory/insular cortices (CTX), were also examined. Cocaine self-administration was increased and cue and cocaine reinstatement were decreased by SCH-23390 infusion into every region when examined across the hour test session, with the exception that cBLA infusion did not alter cocaine reinstatement. In the first 20 min of the session, when SCH-23390 was more localized in the target sites, self-administration was increased by infusion into the CEA, cBLA, BG, and CTX, with lesser increases in the rBLA. Cocaine reinstatement was attenuated during the first 20 min only by infusion into the CEA, rBLA, and CTX. Cue reinstatement was not reliably observed in the first 20 min, but there was a trend for attenuation by infusion into the cBLA, and surprisingly, significant attenuations in the BG and CTX. The findings suggest that D1 receptors in subregions of the amygdala play differential roles in the reinforcing/motivational effects of cocaine, while the cue reinstatement effects are less clear. Further research is needed to examine the novel findings that neighboring regions of the BG and CTX may play a role in motivation for cocaine. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/15957007/Effects_of_SCH_23390_infused_into_the_amygdala_or_adjacent_cortex_and_basal_ganglia_on_cocaine_seeking_and_self_administration_in_rats_ L2 - https://doi.org/10.1038/sj.npp.1300794 DB - PRIME DP - Unbound Medicine ER -