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A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Hum Reprod. 2005 Oct; 20(10):2879-86.HR

Abstract

BACKGROUND

There are few data in the literature regarding the utility of metfomin before and during gonadotrophin administration in women with polycystic ovary syndrome (PCOS). The aim of the present study was to assess the effect of the pre-treatment and co-administration of metformin in infertile PCOS women treated with controlled ovarian stimulation (COS) followed by timed intercourse (TI) or intrauterine insemination (IUI).

METHODS

Seventy insulin-resistant primary infertile women with PCOS were randomized to receive metformin cloridrate (850 mg twice daily; group A) or placebo tablets (two tablets daily; group B) for 3 months. Three trials of COS using highly purified urinary FSH (hpFSH) plus TI/IUI were performed. Number of ampoules of gonadotrophin used, duration of the ovarian stimulation, cycle cancellation, ovulation, pregnancy, abortion, live birth, mono-ovulatory cycles, multiple pregnancies and ovarian hyperstimulation syndrome (OHSS) rates were assessed.

RESULTS

No difference between groups was detected in ovulation, cycle cancellation, pregnancy, abortion, live birth, multiple pregnancies and OHSS rates. The mono-ovulatory cycle rates were significantly (P = 0.002) more frequent in group A than in group B, whereas the days of stimulation for non-cancelled cycles and the number of vials of gonadotrophins used were significantly (P < 0.001) higher in group A than in group B.

CONCLUSION

In insulin-resistant women with PCOS, metformin pre-treatment and co-administration with hpFSH increases the mono-ovulatory cycles.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Naples, Italy. stefanopalomba@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15958399

Citation

Palomba, Stefano, et al. "A Randomized Controlled Trial Evaluating Metformin Pre-treatment and Co-administration in Non-obese Insulin-resistant Women With Polycystic Ovary Syndrome Treated With Controlled Ovarian Stimulation Plus Timed Intercourse or Intrauterine Insemination." Human Reproduction (Oxford, England), vol. 20, no. 10, 2005, pp. 2879-86.
Palomba S, Falbo A, Orio F, et al. A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination. Hum Reprod. 2005;20(10):2879-86.
Palomba, S., Falbo, A., Orio, F., Manguso, F., Russo, T., Tolino, A., Annamaria, C., Dale, B., & Zullo, F. (2005). A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination. Human Reproduction (Oxford, England), 20(10), 2879-86.
Palomba S, et al. A Randomized Controlled Trial Evaluating Metformin Pre-treatment and Co-administration in Non-obese Insulin-resistant Women With Polycystic Ovary Syndrome Treated With Controlled Ovarian Stimulation Plus Timed Intercourse or Intrauterine Insemination. Hum Reprod. 2005;20(10):2879-86. PubMed PMID: 15958399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination. AU - Palomba,Stefano, AU - Falbo,Angela, AU - Orio,Francesco,Jr AU - Manguso,Francesco, AU - Russo,Tiziana, AU - Tolino,Achille, AU - Annamaria,Colao, AU - Dale,Brian, AU - Zullo,Fulvio, Y1 - 2005/06/15/ PY - 2005/6/17/pubmed PY - 2006/1/28/medline PY - 2005/6/17/entrez SP - 2879 EP - 86 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 20 IS - 10 N2 - BACKGROUND: There are few data in the literature regarding the utility of metfomin before and during gonadotrophin administration in women with polycystic ovary syndrome (PCOS). The aim of the present study was to assess the effect of the pre-treatment and co-administration of metformin in infertile PCOS women treated with controlled ovarian stimulation (COS) followed by timed intercourse (TI) or intrauterine insemination (IUI). METHODS: Seventy insulin-resistant primary infertile women with PCOS were randomized to receive metformin cloridrate (850 mg twice daily; group A) or placebo tablets (two tablets daily; group B) for 3 months. Three trials of COS using highly purified urinary FSH (hpFSH) plus TI/IUI were performed. Number of ampoules of gonadotrophin used, duration of the ovarian stimulation, cycle cancellation, ovulation, pregnancy, abortion, live birth, mono-ovulatory cycles, multiple pregnancies and ovarian hyperstimulation syndrome (OHSS) rates were assessed. RESULTS: No difference between groups was detected in ovulation, cycle cancellation, pregnancy, abortion, live birth, multiple pregnancies and OHSS rates. The mono-ovulatory cycle rates were significantly (P = 0.002) more frequent in group A than in group B, whereas the days of stimulation for non-cancelled cycles and the number of vials of gonadotrophins used were significantly (P < 0.001) higher in group A than in group B. CONCLUSION: In insulin-resistant women with PCOS, metformin pre-treatment and co-administration with hpFSH increases the mono-ovulatory cycles. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/15958399/A_randomized_controlled_trial_evaluating_metformin_pre_treatment_and_co_administration_in_non_obese_insulin_resistant_women_with_polycystic_ovary_syndrome_treated_with_controlled_ovarian_stimulation_plus_timed_intercourse_or_intrauterine_insemination_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dei130 DB - PRIME DP - Unbound Medicine ER -