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Modification of oxidative stress by pioglitazone in the heart of alloxan-induced diabetic rabbits.
J Biomed Sci. 2005; 12(3):531-7.JB

Abstract

The study was undertaken to analyze the effect of pioglitazone on superoxide dismutase (Cu, Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R), glutathione (GSH), ascorbic acid (AA), lipid peroxidation products (LPO) and protein carbonyl groups (PCG) in the heart of alloxan-induced diabetic rabbits after 4 and 8 weeks of pioglitazone treatment. In diabetic animals, Cu, Zn-SOD and CAT were elevated by 60 and 55%, and 90 and 77% as compared to controls at 4 and 8 weeks, respectively. GSH-Px, GSSG-R and GSH were diminished by 11, 14 and 33% as compared to controls at 4 or 8 weeks. AA was diminished by 52 and 41%. At P <0.05, pioglitazone normalized the activities of Cu, Zn-SOD, GSH-Px and GSSG-R. The activity of CAT was modified as compared to diabetic non-treated rabbits. After pioglitazone treatment, GSH and AA were increased as compared to diabetic non-treated animals. In diabetic rabbits, LPO was elevated by 52 and 111% and normalized by pioglitazone treatment. PCG was elevated by 72 and 133% and diminished as compared to diabetic non-treated animals at 8 weeks. The study shows that pioglitazone reduces oxidative stress in the heart of diabetic rabbits. In therapy, similar action can improve the cardiovascular system of diabetic patients.

Authors+Show Affiliations

Department of Medicinal Chemistry, Medical University of Lublin, Chodźki Str. 6, 20-093, Lublin, Poland. anna.gumieniczek@am.lublin.pl

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

15959628

Citation

Gumieniczek, Anna. "Modification of Oxidative Stress By Pioglitazone in the Heart of Alloxan-induced Diabetic Rabbits." Journal of Biomedical Science, vol. 12, no. 3, 2005, pp. 531-7.
Gumieniczek A. Modification of oxidative stress by pioglitazone in the heart of alloxan-induced diabetic rabbits. J Biomed Sci. 2005;12(3):531-7.
Gumieniczek, A. (2005). Modification of oxidative stress by pioglitazone in the heart of alloxan-induced diabetic rabbits. Journal of Biomedical Science, 12(3), 531-7.
Gumieniczek A. Modification of Oxidative Stress By Pioglitazone in the Heart of Alloxan-induced Diabetic Rabbits. J Biomed Sci. 2005;12(3):531-7. PubMed PMID: 15959628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modification of oxidative stress by pioglitazone in the heart of alloxan-induced diabetic rabbits. A1 - Gumieniczek,Anna, PY - 2005/03/08/received PY - 2005/04/26/accepted PY - 2005/6/17/pubmed PY - 2006/1/6/medline PY - 2005/6/17/entrez SP - 531 EP - 7 JF - Journal of biomedical science JO - J Biomed Sci VL - 12 IS - 3 N2 - The study was undertaken to analyze the effect of pioglitazone on superoxide dismutase (Cu, Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R), glutathione (GSH), ascorbic acid (AA), lipid peroxidation products (LPO) and protein carbonyl groups (PCG) in the heart of alloxan-induced diabetic rabbits after 4 and 8 weeks of pioglitazone treatment. In diabetic animals, Cu, Zn-SOD and CAT were elevated by 60 and 55%, and 90 and 77% as compared to controls at 4 and 8 weeks, respectively. GSH-Px, GSSG-R and GSH were diminished by 11, 14 and 33% as compared to controls at 4 or 8 weeks. AA was diminished by 52 and 41%. At P <0.05, pioglitazone normalized the activities of Cu, Zn-SOD, GSH-Px and GSSG-R. The activity of CAT was modified as compared to diabetic non-treated rabbits. After pioglitazone treatment, GSH and AA were increased as compared to diabetic non-treated animals. In diabetic rabbits, LPO was elevated by 52 and 111% and normalized by pioglitazone treatment. PCG was elevated by 72 and 133% and diminished as compared to diabetic non-treated animals at 8 weeks. The study shows that pioglitazone reduces oxidative stress in the heart of diabetic rabbits. In therapy, similar action can improve the cardiovascular system of diabetic patients. SN - 1021-7770 UR - https://www.unboundmedicine.com/medline/citation/15959628/Modification_of_oxidative_stress_by_pioglitazone_in_the_heart_of_alloxan_induced_diabetic_rabbits_ L2 - https://dx.doi.org/10.1007/s11373-005-6733-2 DB - PRIME DP - Unbound Medicine ER -