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Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning.
Hippocampus. 2005; 15(5):665-74.H

Abstract

The dorsal hippocampus (DH) is critically involved in the acquisition and expression of trace and contextual fear conditioning. NMDA/glutamate receptor-mediated transmission is thought to be one mechanism mediating the plastic changes that support long-term memories in the DH. However, their precise involvement in acquisition and expression processes has not been defined. To examine this issue, the NMDA receptor antagonist, D,L-2-amino-5-phosphonovaleric acid (APV; 10 microg/microl; 0.5 microl), was infused into the DH prior to conditioning and/or testing, using a trace fear conditioning procedure. All rats were tested for freezing to both tone and context in separate, counterbalanced sessions. The three sessions (1 training and 2 test) were separated by approximately 24 h. Using this design, it was possible to assess the role for DH NMDA receptors in the acquisition versus expression of trace and contextual fear conditioning. APV disrupted acquisition, but not expression, of contextual fear conditioning. By contrast, APV attenuated both acquisition and expression of trace fear memories. Thus, DH NMDA receptors appear to contribute to retrieval of some, but not all, fear memories.

Authors+Show Affiliations

Department of Psychology and Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA. jennifer.quinn@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15959918

Citation

Quinn, Jennifer J., et al. "Dorsal Hippocampus NMDA Receptors Differentially Mediate Trace and Contextual Fear Conditioning." Hippocampus, vol. 15, no. 5, 2005, pp. 665-74.
Quinn JJ, Loya F, Ma QD, et al. Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning. Hippocampus. 2005;15(5):665-74.
Quinn, J. J., Loya, F., Ma, Q. D., & Fanselow, M. S. (2005). Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning. Hippocampus, 15(5), 665-74.
Quinn JJ, et al. Dorsal Hippocampus NMDA Receptors Differentially Mediate Trace and Contextual Fear Conditioning. Hippocampus. 2005;15(5):665-74. PubMed PMID: 15959918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning. AU - Quinn,Jennifer J, AU - Loya,Fred, AU - Ma,Quang D, AU - Fanselow,Michael S, PY - 2005/6/17/pubmed PY - 2005/9/8/medline PY - 2005/6/17/entrez SP - 665 EP - 74 JF - Hippocampus JO - Hippocampus VL - 15 IS - 5 N2 - The dorsal hippocampus (DH) is critically involved in the acquisition and expression of trace and contextual fear conditioning. NMDA/glutamate receptor-mediated transmission is thought to be one mechanism mediating the plastic changes that support long-term memories in the DH. However, their precise involvement in acquisition and expression processes has not been defined. To examine this issue, the NMDA receptor antagonist, D,L-2-amino-5-phosphonovaleric acid (APV; 10 microg/microl; 0.5 microl), was infused into the DH prior to conditioning and/or testing, using a trace fear conditioning procedure. All rats were tested for freezing to both tone and context in separate, counterbalanced sessions. The three sessions (1 training and 2 test) were separated by approximately 24 h. Using this design, it was possible to assess the role for DH NMDA receptors in the acquisition versus expression of trace and contextual fear conditioning. APV disrupted acquisition, but not expression, of contextual fear conditioning. By contrast, APV attenuated both acquisition and expression of trace fear memories. Thus, DH NMDA receptors appear to contribute to retrieval of some, but not all, fear memories. SN - 1050-9631 UR - https://www.unboundmedicine.com/medline/citation/15959918/Dorsal_hippocampus_NMDA_receptors_differentially_mediate_trace_and_contextual_fear_conditioning_ L2 - https://doi.org/10.1002/hipo.20088 DB - PRIME DP - Unbound Medicine ER -