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Anaphylactic reaction after intramuscular injection of cyanocobalamin (vitamin B12): a case report.
J Pak Med Assoc. 2005 May; 55(5):217-9.JP

Abstract

We report a case of anaphylactic reaction to intramuscular injection of cyanocobalamin. This 52-year-old lady was diagnosed as a case of megaloblastic anemia secondary to dietary vitamin B12 deficiency. She had severe anaphylactic reaction after the parenteral administration of cyanocobalamine. Later she received oral vitamin B12 with no adverse effects. The purpose of this case report is to draw attention to the hypersensitive reaction to injectable vitamin B12, which is rarely seen. This could be due to sensitization to the vitamin B12 molecule itself or an IgE mediated reaction. We concluded that anaphylactic reaction to vitamin B12 is a rare but serious side effect and it should be kept in mind while the drug is being administered to the patient, especially via the parenteral route.

Authors+Show Affiliations

Bilwani F
Department of Pathology, The Aga Khan University Hospital, Karachi.
Adil SN
No affiliation info available
Sheikh U
No affiliation info available
Humera A
No affiliation info available
Khurshid M
No affiliation info available

MeSH

AnaphylaxisAnemia, MegaloblasticFemaleHumansInjections, IntramuscularMiddle AgedVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15960291

Citation

Bilwani, Fareena, et al. "Anaphylactic Reaction After Intramuscular Injection of Cyanocobalamin (vitamin B12): a Case Report." JPMA. the Journal of the Pakistan Medical Association, vol. 55, no. 5, 2005, pp. 217-9.
Bilwani F, Adil SN, Sheikh U, et al. Anaphylactic reaction after intramuscular injection of cyanocobalamin (vitamin B12): a case report. J Pak Med Assoc. 2005;55(5):217-9.
Bilwani, F., Adil, S. N., Sheikh, U., Humera, A., & Khurshid, M. (2005). Anaphylactic reaction after intramuscular injection of cyanocobalamin (vitamin B12): a case report. JPMA. the Journal of the Pakistan Medical Association, 55(5), 217-9.
Bilwani F, et al. Anaphylactic Reaction After Intramuscular Injection of Cyanocobalamin (vitamin B12): a Case Report. J Pak Med Assoc. 2005;55(5):217-9. PubMed PMID: 15960291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anaphylactic reaction after intramuscular injection of cyanocobalamin (vitamin B12): a case report. AU - Bilwani,Fareena, AU - Adil,Salman N, AU - Sheikh,Usman, AU - Humera,Ayesha, AU - Khurshid,Mohammad, PY - 2005/6/18/pubmed PY - 2005/7/27/medline PY - 2005/6/18/entrez SP - 217 EP - 9 JF - JPMA. The Journal of the Pakistan Medical Association JO - J Pak Med Assoc VL - 55 IS - 5 N2 - We report a case of anaphylactic reaction to intramuscular injection of cyanocobalamin. This 52-year-old lady was diagnosed as a case of megaloblastic anemia secondary to dietary vitamin B12 deficiency. She had severe anaphylactic reaction after the parenteral administration of cyanocobalamine. Later she received oral vitamin B12 with no adverse effects. The purpose of this case report is to draw attention to the hypersensitive reaction to injectable vitamin B12, which is rarely seen. This could be due to sensitization to the vitamin B12 molecule itself or an IgE mediated reaction. We concluded that anaphylactic reaction to vitamin B12 is a rare but serious side effect and it should be kept in mind while the drug is being administered to the patient, especially via the parenteral route. SN - 0030-9982 UR - https://www.unboundmedicine.com/medline/citation/15960291/Anaphylactic_reaction_after_intramuscular_injection_of_cyanocobalamin__vitamin_B12_:_a_case_report_ DB - PRIME DP - Unbound Medicine ER -