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Plasma levels of alpha beta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease.
Acta Neurobiol Exp (Wars). 2005; 65(2):117-24.AN

Abstract

Plasma alpha beta levels have been examined in sporadic Alzheimer's disease yielding conflicting results; both no difference and an increase in plasma concentrations of alpha beta42 and alpha beta40 in sporadic cases of AD as compared to controls have been reported. Elevated plasma alpha beta42 levels may be detected several years before the onset of symptoms (in mild cognitive impairment stadium). Levels of alpha beta40 and alpha beta42 were measured in plasma from 54 patients with AD, 39 subjects with MCI and 35 controls using a commercially available ELISA. Mean plasma alpha beta42 levels were significantly higher in MCI as compared to both AD (P < 0.001) and control subjects (P < 0.001), while alpha beta40 did not differ between the groups. No correlations were observed between alpha beta levels and age, MMSE scores or gender. According to ROC curve analysis the maximum accuracy in discriminating MCI versus both controls and AD subjects has been achieved using a cut-off value of 3.8.

Authors+Show Affiliations

Department of Psychiatry and Psychotic Disorders, Medical University of Lodz, Poland. tmsobow@csk.umed.lodz.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15960295

Citation

Sobów, Tomasz, et al. "Plasma Levels of Alpha Beta Peptides Are Altered in Amnestic Mild Cognitive Impairment but Not in Sporadic Alzheimer's Disease." Acta Neurobiologiae Experimentalis, vol. 65, no. 2, 2005, pp. 117-24.
Sobów T, Flirski M, Kłoszewska I, et al. Plasma levels of alpha beta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease. Acta Neurobiol Exp (Wars). 2005;65(2):117-24.
Sobów, T., Flirski, M., Kłoszewska, I., & Liberski, P. P. (2005). Plasma levels of alpha beta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease. Acta Neurobiologiae Experimentalis, 65(2), 117-24.
Sobów T, et al. Plasma Levels of Alpha Beta Peptides Are Altered in Amnestic Mild Cognitive Impairment but Not in Sporadic Alzheimer's Disease. Acta Neurobiol Exp (Wars). 2005;65(2):117-24. PubMed PMID: 15960295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of alpha beta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease. AU - Sobów,Tomasz, AU - Flirski,Marcin, AU - Kłoszewska,Iwona, AU - Liberski,Paweł P, PY - 2005/6/18/pubmed PY - 2005/8/6/medline PY - 2005/6/18/entrez SP - 117 EP - 24 JF - Acta neurobiologiae experimentalis JO - Acta Neurobiol Exp (Wars) VL - 65 IS - 2 N2 - Plasma alpha beta levels have been examined in sporadic Alzheimer's disease yielding conflicting results; both no difference and an increase in plasma concentrations of alpha beta42 and alpha beta40 in sporadic cases of AD as compared to controls have been reported. Elevated plasma alpha beta42 levels may be detected several years before the onset of symptoms (in mild cognitive impairment stadium). Levels of alpha beta40 and alpha beta42 were measured in plasma from 54 patients with AD, 39 subjects with MCI and 35 controls using a commercially available ELISA. Mean plasma alpha beta42 levels were significantly higher in MCI as compared to both AD (P < 0.001) and control subjects (P < 0.001), while alpha beta40 did not differ between the groups. No correlations were observed between alpha beta levels and age, MMSE scores or gender. According to ROC curve analysis the maximum accuracy in discriminating MCI versus both controls and AD subjects has been achieved using a cut-off value of 3.8. SN - 0065-1400 UR - https://www.unboundmedicine.com/medline/citation/15960295/Plasma_levels_of_alpha_beta_peptides_are_altered_in_amnestic_mild_cognitive_impairment_but_not_in_sporadic_Alzheimer's_disease_ L2 - http://www.ane.pl/linkout.php?vol=65&amp;no=2&amp;fpp=117 DB - PRIME DP - Unbound Medicine ER -