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Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration.
Paediatr Anaesth. 2005 Jul; 15(7):566-73.PA

Abstract

BACKGROUND

Ibuprofen is a nonsteroidal anti-inflammatory drug which has both peripheral and central analgesic effects. Ibuprofen has been shown to be an effective antipyretic and postoperative analgesic drug both in adults and children with few side effects. Pharmacokinetics of rectal ibuprofen has not been studied, although suppositories are frequently used for perioperative pain control in children.

METHODS

There were four study groups: full-term infants aged 1-7 weeks (n = 9), infants aged 8-25 weeks (n = 8), and infants aged 26-52 weeks (n = 7). Adult patients were 20-40 years old (n = 7). Ibuprofen suppository 20 mg.kg(-1) was administered after induction of anesthesia. Blood samples were collected from 20 min to 10 h after dosing and pharmacokinetic analysis of ibuprofen enantiomers were done.

RESULTS

Both ibuprofen enantiomers were detectable in blood in 20 min. Total ibuprofen plasma concentrations >10 mg.l(-1) were seen from 40 min to 8 h. Values for T(max) of ibuprofen enantiomers and total ibuprofen were higher in the adult group than any of the infant groups (P < 0.05). In addition, values for physiological (standardized) t(1/2) of (R)-(-)- and (S)-(+)-ibuprofen were higher in infants aged 1-7 weeks than the adults (P < 0.05). None of the other pharmacokinetic variables, C(max), AUC, chronological t(1/2) or AUC ratio differed between the groups.

CONCLUSIONS

A single dose of ibuprofen suppository 20 mg.kg(-1) after induction of anesthesia guarantees analgesic plasma concentrations during the early postoperative period. Except for the delayed absorption of ibuprofen in adults and higher physiological t(1/2) in infants aged 1-7 weeks, no major pharmacokinetic differences were observed between study groups.

Authors+Show Affiliations

Department of Anesthesia and Intensive Care, Oulu University Hospital, Oulu, Finland. matti.kyllonen@ppshp.fiNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15960640

Citation

Kyllönen, Matti, et al. "Perioperative Pharmacokinetics of Ibuprofen Enantiomers After Rectal Administration." Paediatric Anaesthesia, vol. 15, no. 7, 2005, pp. 566-73.
Kyllönen M, Olkkola KT, Seppälä T, et al. Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration. Paediatr Anaesth. 2005;15(7):566-73.
Kyllönen, M., Olkkola, K. T., Seppälä, T., & Ryhänen, P. (2005). Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration. Paediatric Anaesthesia, 15(7), 566-73.
Kyllönen M, et al. Perioperative Pharmacokinetics of Ibuprofen Enantiomers After Rectal Administration. Paediatr Anaesth. 2005;15(7):566-73. PubMed PMID: 15960640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration. AU - Kyllönen,Matti, AU - Olkkola,Klaus T, AU - Seppälä,Timo, AU - Ryhänen,Pauli, PY - 2005/6/18/pubmed PY - 2005/10/5/medline PY - 2005/6/18/entrez SP - 566 EP - 73 JF - Paediatric anaesthesia JO - Paediatr Anaesth VL - 15 IS - 7 N2 - BACKGROUND: Ibuprofen is a nonsteroidal anti-inflammatory drug which has both peripheral and central analgesic effects. Ibuprofen has been shown to be an effective antipyretic and postoperative analgesic drug both in adults and children with few side effects. Pharmacokinetics of rectal ibuprofen has not been studied, although suppositories are frequently used for perioperative pain control in children. METHODS: There were four study groups: full-term infants aged 1-7 weeks (n = 9), infants aged 8-25 weeks (n = 8), and infants aged 26-52 weeks (n = 7). Adult patients were 20-40 years old (n = 7). Ibuprofen suppository 20 mg.kg(-1) was administered after induction of anesthesia. Blood samples were collected from 20 min to 10 h after dosing and pharmacokinetic analysis of ibuprofen enantiomers were done. RESULTS: Both ibuprofen enantiomers were detectable in blood in 20 min. Total ibuprofen plasma concentrations >10 mg.l(-1) were seen from 40 min to 8 h. Values for T(max) of ibuprofen enantiomers and total ibuprofen were higher in the adult group than any of the infant groups (P < 0.05). In addition, values for physiological (standardized) t(1/2) of (R)-(-)- and (S)-(+)-ibuprofen were higher in infants aged 1-7 weeks than the adults (P < 0.05). None of the other pharmacokinetic variables, C(max), AUC, chronological t(1/2) or AUC ratio differed between the groups. CONCLUSIONS: A single dose of ibuprofen suppository 20 mg.kg(-1) after induction of anesthesia guarantees analgesic plasma concentrations during the early postoperative period. Except for the delayed absorption of ibuprofen in adults and higher physiological t(1/2) in infants aged 1-7 weeks, no major pharmacokinetic differences were observed between study groups. SN - 1155-5645 UR - https://www.unboundmedicine.com/medline/citation/15960640/Perioperative_pharmacokinetics_of_ibuprofen_enantiomers_after_rectal_administration_ L2 - https://doi.org/10.1111/j.1460-9592.2005.01499.x DB - PRIME DP - Unbound Medicine ER -