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Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease.
Neuroimage 2005; 26(4):1078-85N

Abstract

Functional MRI (fMRI) in established Alzheimer's disease (AD) shows regionally altered blood oxygenation level dependent (BOLD) responses. Mild cognitive impairment (MCI) is thought to represent an intermediate state between health and early Alzheimer's disease. To study this probable early dementia stage pathology, we studied in detail the BOLD response in MCI during visual encoding. 28 MCI patients, 18 AD patients, and 41 healthy elderly controls performed a face encoding task during fMRI scanning. Data were analyzed using orthogonal regressors, each representing different phases of the BOLD response (from slow to fast). Using a mixed effects model, regressor x group interactions were analyzed applying P < 0.05, corrected. In occipital regions, MCI patients could be distinguished significantly better from controls and AD patients with a regressor of the early phase of the (fast) BOLD response than with the regressor of the late (slow) BOLD phase. Occipitally, the early phase BOLD response was significantly diminished in MCI patients compared to controls, and significantly increased when compared to AD. AD patients showed diminished early phase activation in widespread regions throughout the brain when compared to controls. There were no differences in the late (slow) phase of the BOLD response. This study stresses the importance of analyzing early phase BOLD responses and not only using one model of the BOLD response in neurodegenerative diseases. The increasing delay of the BOLD response from controls to MCI to AD may be consistent with the idea that MCI is a transitional state between healthy aging and dementia. Analyzing differences in different phases of the BOLD response introduces new opportunities to understand changes in regional brain dynamics in MCI and how well this may serve as an early marker of AD pathology.

Authors+Show Affiliations

Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. sarb.rombouts@vumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15961047

Citation

Rombouts, Serge A R B., et al. "Delayed Rather Than Decreased BOLD Response as a Marker for Early Alzheimer's Disease." NeuroImage, vol. 26, no. 4, 2005, pp. 1078-85.
Rombouts SA, Goekoop R, Stam CJ, et al. Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease. Neuroimage. 2005;26(4):1078-85.
Rombouts, S. A., Goekoop, R., Stam, C. J., Barkhof, F., & Scheltens, P. (2005). Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease. NeuroImage, 26(4), pp. 1078-85.
Rombouts SA, et al. Delayed Rather Than Decreased BOLD Response as a Marker for Early Alzheimer's Disease. Neuroimage. 2005 Jul 15;26(4):1078-85. PubMed PMID: 15961047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease. AU - Rombouts,Serge A R B, AU - Goekoop,Rutger, AU - Stam,Cornelis J, AU - Barkhof,Frederik, AU - Scheltens,Philip, Y1 - 2005/04/26/ PY - 2004/09/22/received PY - 2005/03/15/revised PY - 2005/03/16/accepted PY - 2005/6/18/pubmed PY - 2005/8/24/medline PY - 2005/6/18/entrez SP - 1078 EP - 85 JF - NeuroImage JO - Neuroimage VL - 26 IS - 4 N2 - Functional MRI (fMRI) in established Alzheimer's disease (AD) shows regionally altered blood oxygenation level dependent (BOLD) responses. Mild cognitive impairment (MCI) is thought to represent an intermediate state between health and early Alzheimer's disease. To study this probable early dementia stage pathology, we studied in detail the BOLD response in MCI during visual encoding. 28 MCI patients, 18 AD patients, and 41 healthy elderly controls performed a face encoding task during fMRI scanning. Data were analyzed using orthogonal regressors, each representing different phases of the BOLD response (from slow to fast). Using a mixed effects model, regressor x group interactions were analyzed applying P < 0.05, corrected. In occipital regions, MCI patients could be distinguished significantly better from controls and AD patients with a regressor of the early phase of the (fast) BOLD response than with the regressor of the late (slow) BOLD phase. Occipitally, the early phase BOLD response was significantly diminished in MCI patients compared to controls, and significantly increased when compared to AD. AD patients showed diminished early phase activation in widespread regions throughout the brain when compared to controls. There were no differences in the late (slow) phase of the BOLD response. This study stresses the importance of analyzing early phase BOLD responses and not only using one model of the BOLD response in neurodegenerative diseases. The increasing delay of the BOLD response from controls to MCI to AD may be consistent with the idea that MCI is a transitional state between healthy aging and dementia. Analyzing differences in different phases of the BOLD response introduces new opportunities to understand changes in regional brain dynamics in MCI and how well this may serve as an early marker of AD pathology. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/15961047/Delayed_rather_than_decreased_BOLD_response_as_a_marker_for_early_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(05)00190-4 DB - PRIME DP - Unbound Medicine ER -