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A role for prefrontal cortex in the extinction of a conditioned taste aversion.
Brain Res. 2005 Jul 27; 1051(1-2):176-82.BR

Abstract

This study used immunohistochemical methods to determine if the medial prefrontal cortex (mPFC) is involved in the extinction of a conditioned taste aversion (CTA). As rats reached 90% reacceptance of a tastant (saccharin: SAC) that had previously been associated with lithium chloride-induced malaise, c-Fos protein expression increased dramatically as compared to animals with active CTAs, animals without CTAs (i.e., explicitly unpaired CS-US exposures) or animals drinking SAC for the first time. These data indicate a role for mPFC (prelimbic and infralimbic cortex) in the formation of a CTA extinction memory.

Authors+Show Affiliations

Department of Psychology and the Neuroscience Program, Baldwin-Wallace College, 275 Eastland Road, Berea, OH 44017-2088, USA. amickley@bw.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15961067

Citation

Mickley, G Andrew, et al. "A Role for Prefrontal Cortex in the Extinction of a Conditioned Taste Aversion." Brain Research, vol. 1051, no. 1-2, 2005, pp. 176-82.
Mickley GA, Kenmuir CL, Yocom AM, et al. A role for prefrontal cortex in the extinction of a conditioned taste aversion. Brain Res. 2005;1051(1-2):176-82.
Mickley, G. A., Kenmuir, C. L., Yocom, A. M., Wellman, J. A., & Biada, J. M. (2005). A role for prefrontal cortex in the extinction of a conditioned taste aversion. Brain Research, 1051(1-2), 176-82.
Mickley GA, et al. A Role for Prefrontal Cortex in the Extinction of a Conditioned Taste Aversion. Brain Res. 2005 Jul 27;1051(1-2):176-82. PubMed PMID: 15961067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A role for prefrontal cortex in the extinction of a conditioned taste aversion. AU - Mickley,G Andrew, AU - Kenmuir,Cynthia L, AU - Yocom,Anna M, AU - Wellman,Justin A, AU - Biada,Jaclyn M, PY - 2004/12/15/received PY - 2005/05/10/revised PY - 2005/05/13/accepted PY - 2005/6/18/pubmed PY - 2005/11/16/medline PY - 2005/6/18/entrez SP - 176 EP - 82 JF - Brain research JO - Brain Res VL - 1051 IS - 1-2 N2 - This study used immunohistochemical methods to determine if the medial prefrontal cortex (mPFC) is involved in the extinction of a conditioned taste aversion (CTA). As rats reached 90% reacceptance of a tastant (saccharin: SAC) that had previously been associated with lithium chloride-induced malaise, c-Fos protein expression increased dramatically as compared to animals with active CTAs, animals without CTAs (i.e., explicitly unpaired CS-US exposures) or animals drinking SAC for the first time. These data indicate a role for mPFC (prelimbic and infralimbic cortex) in the formation of a CTA extinction memory. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/15961067/A_role_for_prefrontal_cortex_in_the_extinction_of_a_conditioned_taste_aversion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(05)00777-8 DB - PRIME DP - Unbound Medicine ER -