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Toenail and plasma levels as biomarkers of selenium exposure.
Ann Epidemiol 2006; 16(1):53-8AE

Abstract

PURPOSE

Both blood and toenail selenium are used to assess selenium exposure in epidemiologic studies. Little is known about the relationship of these biomarkers with each other or about whether there are differences in the relationships of these biomarkers with diet, supplement use, or participant characteristics.

METHODS

Data are from 220 participants in a large cohort study of supplement use and cancer risk. Measures of selenium exposure included supplement use (current and 10-year) from a self-administered questionnaire, an inventory of currently used supplements (multivitamins and single supplements), dietary intake from a food frequency questionnaire (FFQ), and selenium concentration in toenails and plasma.

RESULTS

Plasma and toenail selenium concentrations were significantly correlated (r=.56 [95% confidence interval: .46, .64]). Supplemental selenium was the strongest predictor of both selenium biomarkers, and these associations were slightly stronger when based on the supplement inventory and 10-year self-reported use compared to current self-reported use. Correlations of current and 10-year questionnaire dose and inventory dose with toenail selenium were .26, .36, and .33; for plasma selenium, these were .27, .36, and .36. Neither dietary selenium nor any participant characteristics, except smoking, was related to either biomarker. Current smokers had lower toenail, but not plasma, selenium levels compared to nonsmokers (.89 versus 1.03 microg/g, p = .03); however, the difference was not significant after control for supplement use (p = .09).

CONCLUSIONS

Both toenail and plasma selenium levels similarly reflect selenium intake exposure. There do not appear to be independent associations of toenail or plasma selenium with FFQ-derived selenium intakes, health-related behaviors, or demographic characteristics.

Authors+Show Affiliations

Department of Nutrition, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA. jessie.satia@amgen.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

15961316

Citation

Satia, Jessie A., et al. "Toenail and Plasma Levels as Biomarkers of Selenium Exposure." Annals of Epidemiology, vol. 16, no. 1, 2006, pp. 53-8.
Satia JA, King IB, Morris JS, et al. Toenail and plasma levels as biomarkers of selenium exposure. Ann Epidemiol. 2006;16(1):53-8.
Satia, J. A., King, I. B., Morris, J. S., Stratton, K., & White, E. (2006). Toenail and plasma levels as biomarkers of selenium exposure. Annals of Epidemiology, 16(1), pp. 53-8.
Satia JA, et al. Toenail and Plasma Levels as Biomarkers of Selenium Exposure. Ann Epidemiol. 2006;16(1):53-8. PubMed PMID: 15961316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toenail and plasma levels as biomarkers of selenium exposure. AU - Satia,Jessie A, AU - King,Irena B, AU - Morris,J Steven, AU - Stratton,Kayla, AU - White,Emily, Y1 - 2005/06/15/ PY - 2004/10/01/received PY - 2005/01/25/revised PY - 2005/02/01/accepted PY - 2005/6/18/pubmed PY - 2006/8/2/medline PY - 2005/6/18/entrez SP - 53 EP - 8 JF - Annals of epidemiology JO - Ann Epidemiol VL - 16 IS - 1 N2 - PURPOSE: Both blood and toenail selenium are used to assess selenium exposure in epidemiologic studies. Little is known about the relationship of these biomarkers with each other or about whether there are differences in the relationships of these biomarkers with diet, supplement use, or participant characteristics. METHODS: Data are from 220 participants in a large cohort study of supplement use and cancer risk. Measures of selenium exposure included supplement use (current and 10-year) from a self-administered questionnaire, an inventory of currently used supplements (multivitamins and single supplements), dietary intake from a food frequency questionnaire (FFQ), and selenium concentration in toenails and plasma. RESULTS: Plasma and toenail selenium concentrations were significantly correlated (r=.56 [95% confidence interval: .46, .64]). Supplemental selenium was the strongest predictor of both selenium biomarkers, and these associations were slightly stronger when based on the supplement inventory and 10-year self-reported use compared to current self-reported use. Correlations of current and 10-year questionnaire dose and inventory dose with toenail selenium were .26, .36, and .33; for plasma selenium, these were .27, .36, and .36. Neither dietary selenium nor any participant characteristics, except smoking, was related to either biomarker. Current smokers had lower toenail, but not plasma, selenium levels compared to nonsmokers (.89 versus 1.03 microg/g, p = .03); however, the difference was not significant after control for supplement use (p = .09). CONCLUSIONS: Both toenail and plasma selenium levels similarly reflect selenium intake exposure. There do not appear to be independent associations of toenail or plasma selenium with FFQ-derived selenium intakes, health-related behaviors, or demographic characteristics. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/15961316/Toenail_and_plasma_levels_as_biomarkers_of_selenium_exposure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(05)00088-8 DB - PRIME DP - Unbound Medicine ER -