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Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.
Blood. 2005 Oct 15; 106(8):2879-83.Blood

Abstract

Mammalian nonheme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine. This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells. To test its importance in vivo, we inactivated the murine Cybrd1 gene and assessed tissue iron stores in Cybrd1-null mice. We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron.

Links

Publisher Full Text
ncbi.nlm.nih.gov
linkinghub.elsevier.com
ashpublications.org
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Authors+Show Affiliations

Gunshin H
Children's Hospital, Karp Family Research Laboratories RM 8-125, Boston, MA 02115-5737, USA.
Starr CN
No affiliation info available
Direnzo C
No affiliation info available
Fleming MD
No affiliation info available
Jin J
No affiliation info available
Greer EL
No affiliation info available
Sellers VM
No affiliation info available
Galica SM
No affiliation info available
Andrews NC
No affiliation info available

MeSH

AbsorptionAnimalsCytochrome b GroupDuodenumIron, DietaryLiverMiceMice, KnockoutMutationOxidoreductasesPhenotype

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15961514

Citation

Gunshin, Hiromi, et al. "Cybrd1 (duodenal Cytochrome B) Is Not Necessary for Dietary Iron Absorption in Mice." Blood, vol. 106, no. 8, 2005, pp. 2879-83.
Gunshin H, Starr CN, Direnzo C, et al. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood. 2005;106(8):2879-83.
Gunshin, H., Starr, C. N., Direnzo, C., Fleming, M. D., Jin, J., Greer, E. L., Sellers, V. M., Galica, S. M., & Andrews, N. C. (2005). Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood, 106(8), 2879-83.
Gunshin H, et al. Cybrd1 (duodenal Cytochrome B) Is Not Necessary for Dietary Iron Absorption in Mice. Blood. 2005 Oct 15;106(8):2879-83. PubMed PMID: 15961514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. AU - Gunshin,Hiromi, AU - Starr,Carolyn N, AU - Direnzo,Cristina, AU - Fleming,Mark D, AU - Jin,Jie, AU - Greer,Eric L, AU - Sellers,Vera M, AU - Galica,Stephanie M, AU - Andrews,Nancy C, Y1 - 2005/06/16/ PY - 2005/6/18/pubmed PY - 2005/11/8/medline PY - 2005/6/18/entrez SP - 2879 EP - 83 JF - Blood JO - Blood VL - 106 IS - 8 N2 - Mammalian nonheme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine. This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells. To test its importance in vivo, we inactivated the murine Cybrd1 gene and assessed tissue iron stores in Cybrd1-null mice. We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/15961514/Cybrd1__duodenal_cytochrome_b__is_not_necessary_for_dietary_iron_absorption_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-4971(20)69134-0 DB - PRIME DP - Unbound Medicine ER -