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Angioedema acute hypersensitivity reaction to injectable hyaluronic acid.

Abstract

BACKGROUND

Injectable hyaluronic acid was introduced to European markets in 1996 and has demonstrated a high safety profile. We describe the first reported case of angioedema-type hypersensitivity following injection of the upper lip with non-animal-stabilized hyaluronic acid (NASHA) gel.

OBJECTIVE

To report a case and discuss a potential mechanism for and treatment of angioedema-type hypersensitivity following injection with NASHA gel into the upper lip.

METHODS AND MATERIALS

Not applicable.

RESULTS

Not applicable.

CONCLUSION

Although injectable hyaluronic acid has a high safety profile, this reaction is dramatic. Treatments and potential mechanisms are discussed.

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    MeSH

    Adjuvants, Immunologic
    Angioedema
    Diagnosis, Differential
    Drug Hypersensitivity
    Female
    Gels
    Herpes Labialis
    Humans
    Hyaluronic Acid
    Injections, Intralesional
    Middle Aged

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    15962746