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Angioedema acute hypersensitivity reaction to injectable hyaluronic acid.

Abstract

BACKGROUND

Injectable hyaluronic acid was introduced to European markets in 1996 and has demonstrated a high safety profile. We describe the first reported case of angioedema-type hypersensitivity following injection of the upper lip with non-animal-stabilized hyaluronic acid (NASHA) gel.

OBJECTIVE

To report a case and discuss a potential mechanism for and treatment of angioedema-type hypersensitivity following injection with NASHA gel into the upper lip.

METHODS AND MATERIALS

Not applicable.

RESULTS

Not applicable.

CONCLUSION

Although injectable hyaluronic acid has a high safety profile, this reaction is dramatic. Treatments and potential mechanisms are discussed.

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  • Authors

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    MeSH

    Adjuvants, Immunologic
    Angioedema
    Diagnosis, Differential
    Drug Hypersensitivity
    Female
    Gels
    Herpes Labialis
    Humans
    Hyaluronic Acid
    Injections, Intralesional
    Middle Aged

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    15962746

    Citation

    TY - JOUR T1 - Angioedema acute hypersensitivity reaction to injectable hyaluronic acid. AU - Leonhardt,Janie M, AU - Lawrence,Naomi, AU - Narins,Rhoda S, PY - 2005/6/21/pubmed PY - 2005/7/1/medline PY - 2005/6/21/entrez SP - 577 EP - 9 JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] JO - Dermatol Surg VL - 31 IS - 5 N2 - BACKGROUND: Injectable hyaluronic acid was introduced to European markets in 1996 and has demonstrated a high safety profile. We describe the first reported case of angioedema-type hypersensitivity following injection of the upper lip with non-animal-stabilized hyaluronic acid (NASHA) gel. OBJECTIVE: To report a case and discuss a potential mechanism for and treatment of angioedema-type hypersensitivity following injection with NASHA gel into the upper lip. METHODS AND MATERIALS: Not applicable. RESULTS: Not applicable. CONCLUSION: Although injectable hyaluronic acid has a high safety profile, this reaction is dramatic. Treatments and potential mechanisms are discussed. SN - 1076-0512 UR - https://www.unboundmedicine.com/medline/citation/15962746/Angioedema_acute_hypersensitivity_reaction_to_injectable_hyaluronic_acid_ L2 - http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1076-0512&date=2005&volume=31&issue=5&spage=577 ER -