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Radical prostatectomy versus high-dose rate brachytherapy for prostate cancer: effects on health-related quality of life.
BJU Int. 2005 Jul; 96(1):43-7.BI

Abstract

OBJECTIVE

To examine the effects of different treatments on the health-related quality of life (HRQoL) of men with localized prostate cancer.

PATIENTS AND METHODS

Between October 1997 and August 2002, 182 men diagnosed with prostate cancer (T1c to T3bN0M0) had radical prostatectomy (RP, 89) or (192)iridium high-dose rate brachytherapy (HDR-BT, 93) with external beam radiotherapy, and were followed for > or = 6 months. A postal survey was sent in which HRQoL was assessed using the 36-item Short-Form Health Survey (SF-36) QoL questionnaire, and disease-specific QoL using the University of California Los Angeles Prostate Cancer Index (UCLA-PCI).

RESULTS

Questionnaire responses were obtained from 151 of 182 patients; there was no significant difference in SF-36 scale scores between men treated with RP or HDR-BT. In the UCLA-PCI, the HDR-BT group had better urinary function (P < 0.001) and sexual function scores (P= 0.043). Men treated with RP had better bowel bother scores (P = 0.027). In patients with > or = 2 years of follow-up, urinary function (P < 0.001) and sexual bother (P = 0.029) were better for men treated with HDR-BT than for men treated with RP. Men treated with HDR-BT had significantly better urinary function (P = 0.009) and sexual bother (P = 0.013) even than 30 men treated with unilateral nerve-sparing RP.

CONCLUSIONS

In terms of HRQoL, RP and HDR-BT did not differ, but HDR-BT resulted in better urinary and sexual function than RP. When planning treatment, QoL concerns, including mental health issues associated with prostate cancer, need to be addressed with the patients, as do the potential side-effects.

Authors+Show Affiliations

Department of Urology, Kawasaki Medical School, Kurashiki, Japan. jo@med.kawasaki-m.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15963118

Citation

Jo, Yoshimasa, et al. "Radical Prostatectomy Versus High-dose Rate Brachytherapy for Prostate Cancer: Effects On Health-related Quality of Life." BJU International, vol. 96, no. 1, 2005, pp. 43-7.
Jo Y, Junichi H, Tomohiro F, et al. Radical prostatectomy versus high-dose rate brachytherapy for prostate cancer: effects on health-related quality of life. BJU Int. 2005;96(1):43-7.
Jo, Y., Junichi, H., Tomohiro, F., Yoshinari, I., & Masato, F. (2005). Radical prostatectomy versus high-dose rate brachytherapy for prostate cancer: effects on health-related quality of life. BJU International, 96(1), 43-7.
Jo Y, et al. Radical Prostatectomy Versus High-dose Rate Brachytherapy for Prostate Cancer: Effects On Health-related Quality of Life. BJU Int. 2005;96(1):43-7. PubMed PMID: 15963118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radical prostatectomy versus high-dose rate brachytherapy for prostate cancer: effects on health-related quality of life. AU - Jo,Yoshimasa, AU - Junichi,Hiratsuka, AU - Tomohiro,Fujii, AU - Yoshinari,Imajo, AU - Masato,Fujisawa, PY - 2005/6/21/pubmed PY - 2005/8/10/medline PY - 2005/6/21/entrez SP - 43 EP - 7 JF - BJU international JO - BJU Int VL - 96 IS - 1 N2 - OBJECTIVE: To examine the effects of different treatments on the health-related quality of life (HRQoL) of men with localized prostate cancer. PATIENTS AND METHODS: Between October 1997 and August 2002, 182 men diagnosed with prostate cancer (T1c to T3bN0M0) had radical prostatectomy (RP, 89) or (192)iridium high-dose rate brachytherapy (HDR-BT, 93) with external beam radiotherapy, and were followed for > or = 6 months. A postal survey was sent in which HRQoL was assessed using the 36-item Short-Form Health Survey (SF-36) QoL questionnaire, and disease-specific QoL using the University of California Los Angeles Prostate Cancer Index (UCLA-PCI). RESULTS: Questionnaire responses were obtained from 151 of 182 patients; there was no significant difference in SF-36 scale scores between men treated with RP or HDR-BT. In the UCLA-PCI, the HDR-BT group had better urinary function (P < 0.001) and sexual function scores (P= 0.043). Men treated with RP had better bowel bother scores (P = 0.027). In patients with > or = 2 years of follow-up, urinary function (P < 0.001) and sexual bother (P = 0.029) were better for men treated with HDR-BT than for men treated with RP. Men treated with HDR-BT had significantly better urinary function (P = 0.009) and sexual bother (P = 0.013) even than 30 men treated with unilateral nerve-sparing RP. CONCLUSIONS: In terms of HRQoL, RP and HDR-BT did not differ, but HDR-BT resulted in better urinary and sexual function than RP. When planning treatment, QoL concerns, including mental health issues associated with prostate cancer, need to be addressed with the patients, as do the potential side-effects. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/15963118/Radical_prostatectomy_versus_high_dose_rate_brachytherapy_for_prostate_cancer:_effects_on_health_related_quality_of_life_ L2 - https://doi.org/10.1111/j.1464-410X.2005.05564.x DB - PRIME DP - Unbound Medicine ER -