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Fish intake and risk of incident heart failure.

Abstract

OBJECTIVES

Our aim was to investigate the relation between fish consumption and incidence of congestive heart failure (CHF).

BACKGROUND

The incidence and health burden of CHF are rising, particularly in older persons. Although n-3 fatty acids have effects that could favorably influence risk of CHF, the relation between fish intake and CHF incidence is unknown.

METHODS

Among 4,738 adults age > or =65 years and free of CHF at baseline in 1989-90, usual dietary intake was assessed using a food frequency questionnaire. In a participant subsample, consumption of tuna or other broiled or baked fish, but not fried fish, correlated with plasma phospholipid n-3 fatty acids. Incidence of CHF was prospectively adjudicated.

RESULTS

During 12 years' follow-up, 955 participants developed CHF. In multivariate-adjusted analyses, tuna/other fish consumption was inversely associated with incident CHF, with 20% lower risk with intake 1 to 2 times/week (hazard ratio [HR] = 0.80, 95% confidence interval [CI] = 0.64 to 0.99), 31% lower risk with intake 3 to 4 times/week (HR = 0.69, 95% CI = 0.52 to 0.91), and 32% lower risk with intake > or =5 times/week (HR = 0.68, 95% CI = 0.45 to 1.03), compared with intake <1 time/month (p trend = 0.009). In similar analyses, fried fish consumption was positively associated with incident CHF (p trend = 0.01). Dietary long-chain n-3 fatty acid intake was also inversely associated with CHF (p trend = 0.009), with 37% lower risk in the highest quintile of intake (HR = 0.73, 95% CI = 0.57 to 0.94) compared with the lowest.

CONCLUSIONS

Among older adults, consumption of tuna or other broiled or baked fish, but not fried fish, is associated with lower incidence of CHF. Confirmation in additional studies and evaluation of potential mechanisms is warranted.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. smozaffa@hsph.harvard.edu

    , , ,

    Source

    MeSH

    Aged
    Animals
    Cohort Studies
    Cooking
    Diet
    Diet Surveys
    Disease-Free Survival
    Female
    Fishes
    Heart Failure
    Humans
    Incidence
    Male
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15963403

    Citation

    Mozaffarian, Dariush, et al. "Fish Intake and Risk of Incident Heart Failure." Journal of the American College of Cardiology, vol. 45, no. 12, 2005, pp. 2015-21.
    Mozaffarian D, Bryson CL, Lemaitre RN, et al. Fish intake and risk of incident heart failure. J Am Coll Cardiol. 2005;45(12):2015-21.
    Mozaffarian, D., Bryson, C. L., Lemaitre, R. N., Burke, G. L., & Siscovick, D. S. (2005). Fish intake and risk of incident heart failure. Journal of the American College of Cardiology, 45(12), pp. 2015-21.
    Mozaffarian D, et al. Fish Intake and Risk of Incident Heart Failure. J Am Coll Cardiol. 2005 Jun 21;45(12):2015-21. PubMed PMID: 15963403.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fish intake and risk of incident heart failure. AU - Mozaffarian,Dariush, AU - Bryson,Chris L, AU - Lemaitre,Rozenn N, AU - Burke,Gregory L, AU - Siscovick,David S, PY - 2004/12/26/received PY - 2005/03/08/revised PY - 2005/03/10/accepted PY - 2005/6/21/pubmed PY - 2005/7/15/medline PY - 2005/6/21/entrez SP - 2015 EP - 21 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 45 IS - 12 N2 - OBJECTIVES: Our aim was to investigate the relation between fish consumption and incidence of congestive heart failure (CHF). BACKGROUND: The incidence and health burden of CHF are rising, particularly in older persons. Although n-3 fatty acids have effects that could favorably influence risk of CHF, the relation between fish intake and CHF incidence is unknown. METHODS: Among 4,738 adults age > or =65 years and free of CHF at baseline in 1989-90, usual dietary intake was assessed using a food frequency questionnaire. In a participant subsample, consumption of tuna or other broiled or baked fish, but not fried fish, correlated with plasma phospholipid n-3 fatty acids. Incidence of CHF was prospectively adjudicated. RESULTS: During 12 years' follow-up, 955 participants developed CHF. In multivariate-adjusted analyses, tuna/other fish consumption was inversely associated with incident CHF, with 20% lower risk with intake 1 to 2 times/week (hazard ratio [HR] = 0.80, 95% confidence interval [CI] = 0.64 to 0.99), 31% lower risk with intake 3 to 4 times/week (HR = 0.69, 95% CI = 0.52 to 0.91), and 32% lower risk with intake > or =5 times/week (HR = 0.68, 95% CI = 0.45 to 1.03), compared with intake <1 time/month (p trend = 0.009). In similar analyses, fried fish consumption was positively associated with incident CHF (p trend = 0.01). Dietary long-chain n-3 fatty acid intake was also inversely associated with CHF (p trend = 0.009), with 37% lower risk in the highest quintile of intake (HR = 0.73, 95% CI = 0.57 to 0.94) compared with the lowest. CONCLUSIONS: Among older adults, consumption of tuna or other broiled or baked fish, but not fried fish, is associated with lower incidence of CHF. Confirmation in additional studies and evaluation of potential mechanisms is warranted. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/15963403/Fish_intake_and_risk_of_incident_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(05)00752-7 DB - PRIME DP - Unbound Medicine ER -