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Ferritin in atherosclerosis.
Clin Chim Acta. 2005 Jul 01; 357(1):1-16.CC

Abstract

Iron, an essential element for many important cellular functions in all living organisms, can catalyze the formation of potentially toxic free radicals. Excessive iron is sequestered by ferritin in a nontoxic and readily available form in a cell. Ferritin is composed of 24 subunits of different proportions of two functionally distinct subunits: ferritin H and L. The former is involved in ferroxidase activity necessary for iron uptake and oxidation of ferrous iron, while the latter is involved in nucleation of the iron core. The expression of ferritin is under delicate control and is regulated at both the transcriptional and posttranscriptional levels by iron, cytokines and oxidative stress. Elevated ferritin levels are associated with an increased risk of atherosclerotic coronary artery disease (CAD), the leading cause of death and illness in developed countries. Serum ferritin levels are a good indicator of iron stores in the body. In fact, epidemiological studies have suggested that elevated serum ferritin levels are associated with an increased risk of CAD and myocardial infarction (MI), though inconsistent results were obtained in some other studies. Moreover, recent proteomics and molecular biology studies have shown that ferritin levels in arteries are increased in diseased tissues, which further supports the link of ferritin to CAD/MI. Future studies will determine whether increased ferritin levels can serve as a distinct biomarker for the incidence of CAD/MI and distinguish whether increased ferritin levels are a cause of CAD or a consequence of the disease process.

Authors+Show Affiliations

Center for Molecular Genetics, Department of Molecular Cardiology, ND4-38, Lerner Research Institute, and Center for Cardiovascular Genetics, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15963791

Citation

You, Sun-Ah, and Qing Wang. "Ferritin in Atherosclerosis." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 357, no. 1, 2005, pp. 1-16.
You SA, Wang Q. Ferritin in atherosclerosis. Clin Chim Acta. 2005;357(1):1-16.
You, S. A., & Wang, Q. (2005). Ferritin in atherosclerosis. Clinica Chimica Acta; International Journal of Clinical Chemistry, 357(1), 1-16.
You SA, Wang Q. Ferritin in Atherosclerosis. Clin Chim Acta. 2005 Jul 1;357(1):1-16. PubMed PMID: 15963791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ferritin in atherosclerosis. AU - You,Sun-Ah, AU - Wang,Qing, Y1 - 2005/03/23/ PY - 2004/12/06/received PY - 2005/01/25/revised PY - 2005/02/01/accepted PY - 2005/6/21/pubmed PY - 2005/10/1/medline PY - 2005/6/21/entrez SP - 1 EP - 16 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 357 IS - 1 N2 - Iron, an essential element for many important cellular functions in all living organisms, can catalyze the formation of potentially toxic free radicals. Excessive iron is sequestered by ferritin in a nontoxic and readily available form in a cell. Ferritin is composed of 24 subunits of different proportions of two functionally distinct subunits: ferritin H and L. The former is involved in ferroxidase activity necessary for iron uptake and oxidation of ferrous iron, while the latter is involved in nucleation of the iron core. The expression of ferritin is under delicate control and is regulated at both the transcriptional and posttranscriptional levels by iron, cytokines and oxidative stress. Elevated ferritin levels are associated with an increased risk of atherosclerotic coronary artery disease (CAD), the leading cause of death and illness in developed countries. Serum ferritin levels are a good indicator of iron stores in the body. In fact, epidemiological studies have suggested that elevated serum ferritin levels are associated with an increased risk of CAD and myocardial infarction (MI), though inconsistent results were obtained in some other studies. Moreover, recent proteomics and molecular biology studies have shown that ferritin levels in arteries are increased in diseased tissues, which further supports the link of ferritin to CAD/MI. Future studies will determine whether increased ferritin levels can serve as a distinct biomarker for the incidence of CAD/MI and distinguish whether increased ferritin levels are a cause of CAD or a consequence of the disease process. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/15963791/Ferritin_in_atherosclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(05)00068-9 DB - PRIME DP - Unbound Medicine ER -