Tags

Type your tag names separated by a space and hit enter

Cu/Zn superoxide dismutase plasma levels as a new useful clinical biomarker of oxidative stress in patients with end-stage renal disease.
Clin Biochem 2005; 38(8):700-5CB

Abstract

OBJECTIVES

We wanted to study the imbalance between antioxidant and oxidant generating systems resulting in oxidative stress (SOX) in end-stage renal disease (ESRD). We suggest that the plasma levels of Cu/Zn superoxide dismutase (Cu/Zn SOD) may be a new, sensitive marker of SOX in this population.

DESIGN AND METHODS

We measured the levels of Cu/Zn SOD and the traditional SOX markers-malondialdehyde (MDA), total peroxide, and autoantibodies against oxidized LDL (OxLDL-Ab) in the plasma of 132 uremic patients. In addition, circulating enzyme levels were analyzed in relation to the inflammation and presence of diabetes mellitus (DM).

RESULTS

Cu/Zn SOD levels were significantly higher in chronic renal failure (CRF) patients (P < 0.05), and in both dialyzed groups (both P < 0.001) than in controls, and were positively correlated with MDA, creatinine (both P < 0.001) and OxLDL-Ab (P < 0.01) in the whole uremic group.

CONCLUSIONS

The plasma levels of Cu/Zn SOD may be a simple, sensitive marker of SOX in ESRD, independent from DM and inflammation.

Authors+Show Affiliations

Department of Nephrology and Clinical Transplantation, 14 Zurawia Street, 15-540 Bialystok, Poland. krystynapawlak@poczta.onet.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15963971

Citation

Pawlak, Krystyna, et al. "Cu/Zn Superoxide Dismutase Plasma Levels as a New Useful Clinical Biomarker of Oxidative Stress in Patients With End-stage Renal Disease." Clinical Biochemistry, vol. 38, no. 8, 2005, pp. 700-5.
Pawlak K, Pawlak D, Mysliwiec M. Cu/Zn superoxide dismutase plasma levels as a new useful clinical biomarker of oxidative stress in patients with end-stage renal disease. Clin Biochem. 2005;38(8):700-5.
Pawlak, K., Pawlak, D., & Mysliwiec, M. (2005). Cu/Zn superoxide dismutase plasma levels as a new useful clinical biomarker of oxidative stress in patients with end-stage renal disease. Clinical Biochemistry, 38(8), pp. 700-5.
Pawlak K, Pawlak D, Mysliwiec M. Cu/Zn Superoxide Dismutase Plasma Levels as a New Useful Clinical Biomarker of Oxidative Stress in Patients With End-stage Renal Disease. Clin Biochem. 2005;38(8):700-5. PubMed PMID: 15963971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cu/Zn superoxide dismutase plasma levels as a new useful clinical biomarker of oxidative stress in patients with end-stage renal disease. AU - Pawlak,Krystyna, AU - Pawlak,Dariusz, AU - Mysliwiec,Michal, PY - 2005/01/20/received PY - 2005/02/12/revised PY - 2005/02/24/accepted PY - 2005/6/21/pubmed PY - 2005/11/8/medline PY - 2005/6/21/entrez SP - 700 EP - 5 JF - Clinical biochemistry JO - Clin. Biochem. VL - 38 IS - 8 N2 - OBJECTIVES: We wanted to study the imbalance between antioxidant and oxidant generating systems resulting in oxidative stress (SOX) in end-stage renal disease (ESRD). We suggest that the plasma levels of Cu/Zn superoxide dismutase (Cu/Zn SOD) may be a new, sensitive marker of SOX in this population. DESIGN AND METHODS: We measured the levels of Cu/Zn SOD and the traditional SOX markers-malondialdehyde (MDA), total peroxide, and autoantibodies against oxidized LDL (OxLDL-Ab) in the plasma of 132 uremic patients. In addition, circulating enzyme levels were analyzed in relation to the inflammation and presence of diabetes mellitus (DM). RESULTS: Cu/Zn SOD levels were significantly higher in chronic renal failure (CRF) patients (P < 0.05), and in both dialyzed groups (both P < 0.001) than in controls, and were positively correlated with MDA, creatinine (both P < 0.001) and OxLDL-Ab (P < 0.01) in the whole uremic group. CONCLUSIONS: The plasma levels of Cu/Zn SOD may be a simple, sensitive marker of SOX in ESRD, independent from DM and inflammation. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/15963971/Cu/Zn_superoxide_dismutase_plasma_levels_as_a_new_useful_clinical_biomarker_of_oxidative_stress_in_patients_with_end_stage_renal_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(05)00064-0 DB - PRIME DP - Unbound Medicine ER -