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Oxidative stress effects fibrinolytic system in dialysis uraemic patients.
Thromb Res 2006; 117(5):517-22TR

Abstract

INTRODUCTION

Enhanced oxidative stress (SOX) and changes in the fibrinolytic system are common in end-stage renal failure patients undergoing maintenance dialysis. This study attempted to verify the existence of a relationship between SOX documented by Cu/Zn superoxide dismutase (Cu/Zn SOD) and fibrinolysis analyzed by tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1) and plasmin/antiplasmin (PAP) complexes in dialysis patients.

MATERIALS AND METHODS

Twenty-seven patients on maintenance haemodialysis (HD) and 16 on maintenance peritoneal dialysis (CAPD) were examined together with 18 healthy controls. Pre-dialysis blood levels of all the parameters were determined using commercially ELISA kits.

RESULTS

Cu/Zn SOD, uPA and PAP levels were increased in both groups of dialyzed patients compared to the controls. PAI-1 was significantly lower in CAPD subjects compared to HD subjects and control group. PAI-1/uPA ratio and PAI-1/tPA ratio were significantly decreased in CAPD and HD compared to controls, being significantly lower in CAPD patients relative to HD patients. In the patients, increased Cu/Zn SOD levels directly correlated with those of uPA (r=0.565, p<0.0001) and PAP (r=0.335, p<0.05); the fibrinolytic markers were also positively associated with each other (r=0.377, p<0.05).

CONCLUSIONS

The positive association between Cu/Zn SOD and both uPA as well as PAP levels suggests a link between SOX and the fibrinolytic activity in dialysis patients. We hypothesize that increased SOX-mediated fibrinolytic activity may be a part of the counter-system against activation of blood coagulation in these patients.

Authors+Show Affiliations

Department of Nephrology and Clinical Transplantation, Medical University of Bialystok, 14 Zurawia St., 15-540 Bialystok, Poland. krystynapawlak@poczta.onset.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15964061

Citation

Pawlak, Krystyna, et al. "Oxidative Stress Effects Fibrinolytic System in Dialysis Uraemic Patients." Thrombosis Research, vol. 117, no. 5, 2006, pp. 517-22.
Pawlak K, Pawlak D, Mysliwiec M. Oxidative stress effects fibrinolytic system in dialysis uraemic patients. Thromb Res. 2006;117(5):517-22.
Pawlak, K., Pawlak, D., & Mysliwiec, M. (2006). Oxidative stress effects fibrinolytic system in dialysis uraemic patients. Thrombosis Research, 117(5), pp. 517-22.
Pawlak K, Pawlak D, Mysliwiec M. Oxidative Stress Effects Fibrinolytic System in Dialysis Uraemic Patients. Thromb Res. 2006;117(5):517-22. PubMed PMID: 15964061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress effects fibrinolytic system in dialysis uraemic patients. AU - Pawlak,Krystyna, AU - Pawlak,Dariusz, AU - Mysliwiec,Michal, Y1 - 2005/06/16/ PY - 2005/02/28/received PY - 2005/04/11/revised PY - 2005/05/03/accepted PY - 2005/6/21/pubmed PY - 2006/9/20/medline PY - 2005/6/21/entrez SP - 517 EP - 22 JF - Thrombosis research JO - Thromb. Res. VL - 117 IS - 5 N2 - INTRODUCTION: Enhanced oxidative stress (SOX) and changes in the fibrinolytic system are common in end-stage renal failure patients undergoing maintenance dialysis. This study attempted to verify the existence of a relationship between SOX documented by Cu/Zn superoxide dismutase (Cu/Zn SOD) and fibrinolysis analyzed by tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1) and plasmin/antiplasmin (PAP) complexes in dialysis patients. MATERIALS AND METHODS: Twenty-seven patients on maintenance haemodialysis (HD) and 16 on maintenance peritoneal dialysis (CAPD) were examined together with 18 healthy controls. Pre-dialysis blood levels of all the parameters were determined using commercially ELISA kits. RESULTS: Cu/Zn SOD, uPA and PAP levels were increased in both groups of dialyzed patients compared to the controls. PAI-1 was significantly lower in CAPD subjects compared to HD subjects and control group. PAI-1/uPA ratio and PAI-1/tPA ratio were significantly decreased in CAPD and HD compared to controls, being significantly lower in CAPD patients relative to HD patients. In the patients, increased Cu/Zn SOD levels directly correlated with those of uPA (r=0.565, p<0.0001) and PAP (r=0.335, p<0.05); the fibrinolytic markers were also positively associated with each other (r=0.377, p<0.05). CONCLUSIONS: The positive association between Cu/Zn SOD and both uPA as well as PAP levels suggests a link between SOX and the fibrinolytic activity in dialysis patients. We hypothesize that increased SOX-mediated fibrinolytic activity may be a part of the counter-system against activation of blood coagulation in these patients. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/15964061/Oxidative_stress_effects_fibrinolytic_system_in_dialysis_uraemic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(05)00207-0 DB - PRIME DP - Unbound Medicine ER -