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[Technical aspects and relevance of energy expenditure and physical activity assessment in clinical research for cystic fibrosis patients].
Arch Pediatr 2005; 12(7):1139-44AP

Abstract

Cystic fibrosis (CF) is characterized by deteriorating lung function and mal-digestion, which result in growth failure and/or under-nutrition. Several factors, alone or combined, contribute to malnutrition in CF: poor energy intake, elevation of energy loss as a result of malabsorption, increasing resting energy expenditure due to genetic mutation and/or pulmonary exacerbation. Several techniques have been used to assess energy expenditure and physical activity in order to better understand mechanisms of malnutrition in CF and follow therapeutic interventions. Indirect calorimetry (IC) studies have shown that resting energy expenditure (REE) was 10-22% higher than predictive values. This increase could be attributed to chronic inflammation as a result of Pseudomonas aeruginosa (PA) infection. Indeed, intravenous antibiotic therapy decreases REE. Doubly labelled water technique and heart rate monitoring calibrated against IC techniques shows that total energy expenditure (TEE) was not different than in healthy children. Physical activity level assessed by the ratio TEE-REE is also not different between CF of healthy children. Recently, new accelerometry technics, easier to use and less invasive have been successfully used in order to assess physical activity level in CF. Precise and ambulatory assessment of energy expenditure and physical activity permit to check and adapt dietary allowances in CF. These techniques could be simultaneously used and be helpful to assess efficacy of intervention studies.

Authors+Show Affiliations

Unité de gastroentérologie, hépatologie et nutrition, centre de ressources et de compétences pour la mucoviscidose, et EA 3925, clinique de pédiatrie, hôpital Jeanne-de-Flandre, CHRU de Lille, université de Lille-II, France. l-beghin@chru-lille.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

15964531

Citation

Béghin, L, et al. "[Technical Aspects and Relevance of Energy Expenditure and Physical Activity Assessment in Clinical Research for Cystic Fibrosis Patients]." Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, vol. 12, no. 7, 2005, pp. 1139-44.
Béghin L, Michaud L, Turck D, et al. [Technical aspects and relevance of energy expenditure and physical activity assessment in clinical research for cystic fibrosis patients]. Arch Pediatr. 2005;12(7):1139-44.
Béghin, L., Michaud, L., Turck, D., & Gottrand, F. (2005). [Technical aspects and relevance of energy expenditure and physical activity assessment in clinical research for cystic fibrosis patients]. Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, 12(7), pp. 1139-44.
Béghin L, et al. [Technical Aspects and Relevance of Energy Expenditure and Physical Activity Assessment in Clinical Research for Cystic Fibrosis Patients]. Arch Pediatr. 2005;12(7):1139-44. PubMed PMID: 15964531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Technical aspects and relevance of energy expenditure and physical activity assessment in clinical research for cystic fibrosis patients]. AU - Béghin,L, AU - Michaud,L, AU - Turck,D, AU - Gottrand,F, PY - 2004/08/17/received PY - 2005/03/08/accepted PY - 2005/6/21/pubmed PY - 2005/8/18/medline PY - 2005/6/21/entrez SP - 1139 EP - 44 JF - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JO - Arch Pediatr VL - 12 IS - 7 N2 - Cystic fibrosis (CF) is characterized by deteriorating lung function and mal-digestion, which result in growth failure and/or under-nutrition. Several factors, alone or combined, contribute to malnutrition in CF: poor energy intake, elevation of energy loss as a result of malabsorption, increasing resting energy expenditure due to genetic mutation and/or pulmonary exacerbation. Several techniques have been used to assess energy expenditure and physical activity in order to better understand mechanisms of malnutrition in CF and follow therapeutic interventions. Indirect calorimetry (IC) studies have shown that resting energy expenditure (REE) was 10-22% higher than predictive values. This increase could be attributed to chronic inflammation as a result of Pseudomonas aeruginosa (PA) infection. Indeed, intravenous antibiotic therapy decreases REE. Doubly labelled water technique and heart rate monitoring calibrated against IC techniques shows that total energy expenditure (TEE) was not different than in healthy children. Physical activity level assessed by the ratio TEE-REE is also not different between CF of healthy children. Recently, new accelerometry technics, easier to use and less invasive have been successfully used in order to assess physical activity level in CF. Precise and ambulatory assessment of energy expenditure and physical activity permit to check and adapt dietary allowances in CF. These techniques could be simultaneously used and be helpful to assess efficacy of intervention studies. SN - 0929-693X UR - https://www.unboundmedicine.com/medline/citation/15964531/[Technical_aspects_and_relevance_of_energy_expenditure_and_physical_activity_assessment_in_clinical_research_for_cystic_fibrosis_patients]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-693X(05)00150-8 DB - PRIME DP - Unbound Medicine ER -