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Isolation of a genotypically unique H5N1 influenza virus from duck meat imported into Japan from China.
Virology 2005; 339(1):101-9V

Abstract

An H5N1 influenza A virus was isolated from duck meat processed for human consumption, imported to Japan from Shandong Province, China in 2003. This virus was antigenically different from other H5 viruses, including the Hong Kong H5N1 viruses isolated from humans in 1997 and 2003. Sequence analysis revealed that six genes (PB1, PA, HA, NA, M, and NS) of this virus showed >97% nucleotide identity with their counterparts from recent H5N1 viruses, but that the remaining two genes (PB2 and NP) were derived from other unknown viruses. This duck meat isolate was highly pathogenic to chickens upon intravenous or intranasal inoculation, replicated well in the lungs of mice and spread to the brain, but was not as pathogenic in mice as H5N1 human isolates (with a dose lethal to 50% of mice (MLD50)=5x10(6) 50% egg infectious doses [EID50]). However, viruses isolated from the brain of mice previously infected with the virus were substantially more pathogenic (MLD50=approximately 10(2) EID50) and possessed some amino acid substitutions relative to the original virus. These results show that poultry products contaminated with influenza viruses of high pathogenic potential to mammals are a threat to public health even in countries where the virus is not enzootic and represent a possible source of influenza outbreaks in poultry.

Authors+Show Affiliations

Department of Infectious Diseases, National Institute of Animal Health, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan. masema@affrc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15964604

Citation

Mase, Masaji, et al. "Isolation of a Genotypically Unique H5N1 Influenza Virus From Duck Meat Imported Into Japan From China." Virology, vol. 339, no. 1, 2005, pp. 101-9.
Mase M, Eto M, Tanimura N, et al. Isolation of a genotypically unique H5N1 influenza virus from duck meat imported into Japan from China. Virology. 2005;339(1):101-9.
Mase, M., Eto, M., Tanimura, N., Imai, K., Tsukamoto, K., Horimoto, T., ... Yamaguchi, S. (2005). Isolation of a genotypically unique H5N1 influenza virus from duck meat imported into Japan from China. Virology, 339(1), pp. 101-9.
Mase M, et al. Isolation of a Genotypically Unique H5N1 Influenza Virus From Duck Meat Imported Into Japan From China. Virology. 2005 Aug 15;339(1):101-9. PubMed PMID: 15964604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of a genotypically unique H5N1 influenza virus from duck meat imported into Japan from China. AU - Mase,Masaji, AU - Eto,Mariko, AU - Tanimura,Nobuhiko, AU - Imai,Kunitoshi, AU - Tsukamoto,Kenji, AU - Horimoto,Taisuke, AU - Kawaoka,Yoshihiro, AU - Yamaguchi,Shigeo, PY - 2005/02/25/received PY - 2005/03/25/revised PY - 2005/05/10/accepted PY - 2005/6/21/pubmed PY - 2005/10/8/medline PY - 2005/6/21/entrez SP - 101 EP - 9 JF - Virology JO - Virology VL - 339 IS - 1 N2 - An H5N1 influenza A virus was isolated from duck meat processed for human consumption, imported to Japan from Shandong Province, China in 2003. This virus was antigenically different from other H5 viruses, including the Hong Kong H5N1 viruses isolated from humans in 1997 and 2003. Sequence analysis revealed that six genes (PB1, PA, HA, NA, M, and NS) of this virus showed >97% nucleotide identity with their counterparts from recent H5N1 viruses, but that the remaining two genes (PB2 and NP) were derived from other unknown viruses. This duck meat isolate was highly pathogenic to chickens upon intravenous or intranasal inoculation, replicated well in the lungs of mice and spread to the brain, but was not as pathogenic in mice as H5N1 human isolates (with a dose lethal to 50% of mice (MLD50)=5x10(6) 50% egg infectious doses [EID50]). However, viruses isolated from the brain of mice previously infected with the virus were substantially more pathogenic (MLD50=approximately 10(2) EID50) and possessed some amino acid substitutions relative to the original virus. These results show that poultry products contaminated with influenza viruses of high pathogenic potential to mammals are a threat to public health even in countries where the virus is not enzootic and represent a possible source of influenza outbreaks in poultry. SN - 0042-6822 UR - https://www.unboundmedicine.com/medline/citation/15964604/Isolation_of_a_genotypically_unique_H5N1_influenza_virus_from_duck_meat_imported_into_Japan_from_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(05)00295-3 DB - PRIME DP - Unbound Medicine ER -