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Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats.
Food Chem Toxicol. 2005 Sep; 43(9):1433-9.FC

Abstract

Abnormalities in lipid profile are one of the most common complications in diabetes mellitus, which is found in about 40% of diabetics. In the present study, anti-hyperlipidemic efficacy of Eugenia jambolana seed kernel (EJs-kernel) was evaluated in streptozotocin (STZ)-induced diabetic rats and the efficacy was compared with standard hypoglycemic drug, glibenclamide. The effect of oral administration of ethanolic extract of EJs-kernel (100 mg/kg body weight) was examined on the levels of cholesterol, phospholipids, triglycerides and free fatty acids in the plasma, liver and kidney tissues of STZ (55 mg/kg body weight)-induced diabetic rats. The plasma lipoproteins and tissues fatty acid composition were also monitored. STZ-induced diabetic rats, showed significant increase in the levels of cholesterol, phospholipids, triglycerides and free fatty acids which were considerably restored to near normal in EJs-kernel or glibenclamide treated animals. The plasma lipoproteins (HDL, LDL, VLDL-cholesterol) and fatty acid composition were altered in STZ-induced diabetic rats and these levels were also reverted back to near normalcy by EJs-kernel or glibenclamide treatment. It may be concluded that, EJs-kernel possesses hypolipidemic effect, which may be due to the presence of flavonoids, saponins, glycosides and triterpenoids in the extract. The hypolipidemic effect mediated by EJs-kernel may also be anticipated to have biological significance and provide a scientific rationale for the use of EJs-kernel as an anti-diabetic plant.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15964674

Citation

Ravi, Kasiappan, et al. "Antihyperlipidemic Effect of Eugenia Jambolana Seed Kernel On Streptozotocin-induced Diabetes in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 43, no. 9, 2005, pp. 1433-9.
Ravi K, Rajasekaran S, Subramanian S. Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food Chem Toxicol. 2005;43(9):1433-9.
Ravi, K., Rajasekaran, S., & Subramanian, S. (2005). Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 43(9), 1433-9.
Ravi K, Rajasekaran S, Subramanian S. Antihyperlipidemic Effect of Eugenia Jambolana Seed Kernel On Streptozotocin-induced Diabetes in Rats. Food Chem Toxicol. 2005;43(9):1433-9. PubMed PMID: 15964674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. AU - Ravi,Kasiappan, AU - Rajasekaran,Subbaih, AU - Subramanian,Sorimuthu, PY - 2005/04/11/received PY - 2005/04/11/accepted PY - 2005/6/21/pubmed PY - 2005/9/28/medline PY - 2005/6/21/entrez SP - 1433 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 43 IS - 9 N2 - Abnormalities in lipid profile are one of the most common complications in diabetes mellitus, which is found in about 40% of diabetics. In the present study, anti-hyperlipidemic efficacy of Eugenia jambolana seed kernel (EJs-kernel) was evaluated in streptozotocin (STZ)-induced diabetic rats and the efficacy was compared with standard hypoglycemic drug, glibenclamide. The effect of oral administration of ethanolic extract of EJs-kernel (100 mg/kg body weight) was examined on the levels of cholesterol, phospholipids, triglycerides and free fatty acids in the plasma, liver and kidney tissues of STZ (55 mg/kg body weight)-induced diabetic rats. The plasma lipoproteins and tissues fatty acid composition were also monitored. STZ-induced diabetic rats, showed significant increase in the levels of cholesterol, phospholipids, triglycerides and free fatty acids which were considerably restored to near normal in EJs-kernel or glibenclamide treated animals. The plasma lipoproteins (HDL, LDL, VLDL-cholesterol) and fatty acid composition were altered in STZ-induced diabetic rats and these levels were also reverted back to near normalcy by EJs-kernel or glibenclamide treatment. It may be concluded that, EJs-kernel possesses hypolipidemic effect, which may be due to the presence of flavonoids, saponins, glycosides and triterpenoids in the extract. The hypolipidemic effect mediated by EJs-kernel may also be anticipated to have biological significance and provide a scientific rationale for the use of EJs-kernel as an anti-diabetic plant. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/15964674/Antihyperlipidemic_effect_of_Eugenia_jambolana_seed_kernel_on_streptozotocin_induced_diabetes_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(05)00137-7 DB - PRIME DP - Unbound Medicine ER -