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Factors associated with methadone maintenance therapy use among a cohort of polysubstance using injection drug users in Vancouver.
Drug Alcohol Depend. 2005 Dec 12; 80(3):329-35.DA

Abstract

We identified methadone maintenance therapy (MMT) use during follow-up interviews and examined associations between MMT use and socio-demographic and drug-related variables using generalized estimating equations (GEE). Of the 1587 participants recruited into this cohort, 170 (11%) were enrolled in MMT at baseline and additional 498 (31%) initiated MMT during follow-up. Of those ever enrolled in MMT, 406 (61%) ceased MMT and re-initiated MMT on more than one occasion. The median treatment duration was 14.4 months. Factors that were negatively and significantly associated with MMT use in multivariate analyses included: Aboriginal ethnicity (adjusted odds ratio [AOR] = 0.40); recent incarceration (AOR = 0.79); sex trade involvement (AOR = 0.87); syringe lending (AOR = 0.72); heroin injection (AOR = 0.64), whereas female gender (AOR = 2.47), HIV positivity (AOR = 1.57), and crack cocaine smoking (AOR = 1.23) were positively and significantly associated with being on MMT. Unstable housing, syringe borrowing, non-fatal overdose, cocaine injection, and residence in Vancouver's Downtown Eastside were not associated with MMT use in multivariate analyses. Our study demonstrates high rates of initiation of and retention in MMT among local IDUs. While the use of MMT was associated with reductions in heroin use and HIV risk behavior, barriers to Aboriginal IDUs were evident, and the association with increased crack cocaine use deserves further study.

Authors+Show Affiliations

British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6. tkerr@cfenet.ubc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15964714

Citation

Kerr, Thomas, et al. "Factors Associated With Methadone Maintenance Therapy Use Among a Cohort of Polysubstance Using Injection Drug Users in Vancouver." Drug and Alcohol Dependence, vol. 80, no. 3, 2005, pp. 329-35.
Kerr T, Marsh D, Li K, et al. Factors associated with methadone maintenance therapy use among a cohort of polysubstance using injection drug users in Vancouver. Drug Alcohol Depend. 2005;80(3):329-35.
Kerr, T., Marsh, D., Li, K., Montaner, J., & Wood, E. (2005). Factors associated with methadone maintenance therapy use among a cohort of polysubstance using injection drug users in Vancouver. Drug and Alcohol Dependence, 80(3), 329-35.
Kerr T, et al. Factors Associated With Methadone Maintenance Therapy Use Among a Cohort of Polysubstance Using Injection Drug Users in Vancouver. Drug Alcohol Depend. 2005 Dec 12;80(3):329-35. PubMed PMID: 15964714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with methadone maintenance therapy use among a cohort of polysubstance using injection drug users in Vancouver. AU - Kerr,Thomas, AU - Marsh,David, AU - Li,Kathy, AU - Montaner,Julio, AU - Wood,Evan, Y1 - 2005/06/17/ PY - 2004/11/03/received PY - 2005/04/23/revised PY - 2005/05/06/accepted PY - 2005/6/21/pubmed PY - 2006/3/22/medline PY - 2005/6/21/entrez SP - 329 EP - 35 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 80 IS - 3 N2 - We identified methadone maintenance therapy (MMT) use during follow-up interviews and examined associations between MMT use and socio-demographic and drug-related variables using generalized estimating equations (GEE). Of the 1587 participants recruited into this cohort, 170 (11%) were enrolled in MMT at baseline and additional 498 (31%) initiated MMT during follow-up. Of those ever enrolled in MMT, 406 (61%) ceased MMT and re-initiated MMT on more than one occasion. The median treatment duration was 14.4 months. Factors that were negatively and significantly associated with MMT use in multivariate analyses included: Aboriginal ethnicity (adjusted odds ratio [AOR] = 0.40); recent incarceration (AOR = 0.79); sex trade involvement (AOR = 0.87); syringe lending (AOR = 0.72); heroin injection (AOR = 0.64), whereas female gender (AOR = 2.47), HIV positivity (AOR = 1.57), and crack cocaine smoking (AOR = 1.23) were positively and significantly associated with being on MMT. Unstable housing, syringe borrowing, non-fatal overdose, cocaine injection, and residence in Vancouver's Downtown Eastside were not associated with MMT use in multivariate analyses. Our study demonstrates high rates of initiation of and retention in MMT among local IDUs. While the use of MMT was associated with reductions in heroin use and HIV risk behavior, barriers to Aboriginal IDUs were evident, and the association with increased crack cocaine use deserves further study. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/15964714/Factors_associated_with_methadone_maintenance_therapy_use_among_a_cohort_of_polysubstance_using_injection_drug_users_in_Vancouver_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(05)00161-4 DB - PRIME DP - Unbound Medicine ER -